GB2108964B - 1-b-d-arabinofuranosyl-(e)-5-(2-halogenovinyl)uracil-5'-phosphates - Google Patents

1-b-d-arabinofuranosyl-(e)-5-(2-halogenovinyl)uracil-5'-phosphates

Info

Publication number
GB2108964B
GB2108964B GB08225547A GB8225547A GB2108964B GB 2108964 B GB2108964 B GB 2108964B GB 08225547 A GB08225547 A GB 08225547A GB 8225547 A GB8225547 A GB 8225547A GB 2108964 B GB2108964 B GB 2108964B
Authority
GB
United Kingdom
Prior art keywords
halogenovinyl
arabinofuranosyl
uracil
phosphates
phosphorylation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08225547A
Other languages
English (en)
Other versions
GB2108964A (en
Inventor
Shinji Sakata
Haruhiko Machida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15306105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB2108964(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Publication of GB2108964A publication Critical patent/GB2108964A/en
Application granted granted Critical
Publication of GB2108964B publication Critical patent/GB2108964B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
GB08225547A 1981-09-09 1982-09-08 1-b-d-arabinofuranosyl-(e)-5-(2-halogenovinyl)uracil-5'-phosphates Expired GB2108964B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56142045A JPS5843993A (ja) 1981-09-09 1981-09-09 １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法

Publications (2)

Publication Number Publication Date
GB2108964A GB2108964A (en) 1983-05-25
GB2108964B true GB2108964B (en) 1985-04-11

Family

ID=15306105

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08225547A Expired GB2108964B (en) 1981-09-09 1982-09-08 1-b-d-arabinofuranosyl-(e)-5-(2-halogenovinyl)uracil-5'-phosphates

Country Status (12)

Country Link
US (1) US4542210A (enExample)
EP (1) EP0074101B1 (enExample)
JP (1) JPS5843993A (enExample)
KR (1) KR890000762B1 (enExample)
AT (1) ATE12503T1 (enExample)
AU (1) AU552353B2 (enExample)
CA (1) CA1204107A (enExample)
DE (1) DE3262887D1 (enExample)
ES (1) ES8308570A1 (enExample)
GB (1) GB2108964B (enExample)
MY (1) MY8700826A (enExample)
SG (1) SG81787G (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
JPS58225097A (ja) * 1982-06-23 1983-12-27 Yamasa Shoyu Co Ltd ヌクレオシド５′−アルキルもしくはアルケニルりん酸
NZ205619A (en) * 1982-09-17 1987-09-30 Glaxo Group Ltd 5-halovinyl-2'-deoxyuridines and pharmaceutical compositions
US4658044A (en) * 1983-09-16 1987-04-14 Glaxo Group Limited Intermediates for uracil derivatives
ZA85578B (en) * 1985-01-24 1985-07-22 Neopharmed S.P.A. Acylated derivatives of cytidine-diphosphate-choline,process for their preparation and their therapeutic use
GB8912972D0 (en) * 1989-06-06 1989-07-26 Wellcome Found Therapeutic nucleosides
US5446031A (en) * 1991-04-24 1995-08-29 Yamasa Shuyu Kabushiki Kaisha 1-β-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil derivatives
AU645422B2 (en) * 1991-04-24 1994-01-13 Yamasa Shoyu Kabushiki Kaisha 1-beta-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)-uracil derivative
ATE413881T1 (de) * 1997-08-08 2008-11-15 Celmed Oncology Usa Inc Verfahren und zubereitungen um resistenz gegen biologische oder chemische therapien zu überwinden
DK1045897T3 (da) 1998-01-23 2002-05-13 Newbiotics Inc Enzymatisk katalyserede, terapeutiske midler
US7462605B2 (en) * 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
US6653318B1 (en) * 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
US6683061B1 (en) * 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
BR0012676A (pt) 1999-07-22 2003-07-01 Newbiotics Inc Métodos para tratamento de tumores resistentes a terapia
WO2002056832A2 (en) * 2001-01-19 2002-07-25 Newbiotics, Inc. Methods to treat autoimmune and inflammatory conditions
AU2002360697B2 (en) 2001-12-20 2009-04-23 Beth Israel Deaconess Medical Center Treatment of EBV and KHSV infection and associated abnormal cellular proliferation
JP4964473B2 (ja) * 2006-02-10 2012-06-27 アリジェン製薬株式会社 ピリミジンヌクレオシド誘導体及びその塩
WO2008099492A1 (ja) * 2007-02-15 2008-08-21 Arigen Pharmaceuticals, Inc. ピリミジンヌクレオシド誘導体及びその塩

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1157275A (en) * 1965-07-27 1969-07-02 Takeda Chemical Industries Ltd A Method for the Production of 5'-Ribonucleotide
US3382232A (en) * 1965-08-26 1968-05-07 Takeda Chemical Industries Ltd Method for the production of 5'-ribonucleotide
FR5616M (enExample) * 1966-07-29 1968-01-15
EP0015584A3 (de) * 1979-03-12 1980-12-10 Kailash Kumar Dr. Prof. Gauri Neue Nukleotide, Verfahren zu ihrer Herstellung und Arzneimittel
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
US4247544A (en) * 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
GB2060604B (en) * 1979-10-03 1983-11-23 Univ Birmingham And Stichting E15-(2-halogenovinyl)-2'-deoxycytidines
JPS5687599A (en) * 1979-12-19 1981-07-16 Yamasa Shoyu Co Ltd E 55 22halogenovinyl arabinofuranosyluracil and its preparation
JPS5714598A (en) * 1980-06-30 1982-01-25 Yamasa Shoyu Co Ltd 5-substituted-1-beta-d-arabinofuranosyluracil derivative and its preparation
US4383990A (en) * 1980-10-01 1983-05-17 Beecham Group Limited Antiviral agents, their preparation and use
JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法

Also Published As

Publication number Publication date
KR840001589A (ko) 1984-05-07
AU8799682A (en) 1983-03-17
SG81787G (en) 1988-04-15
DE3262887D1 (en) 1985-05-09
JPS637559B2 (enExample) 1988-02-17
ES515573A0 (es) 1983-09-16
ATE12503T1 (de) 1985-04-15
JPS5843993A (ja) 1983-03-14
MY8700826A (en) 1987-12-31
EP0074101A1 (en) 1983-03-16
CA1204107A (en) 1986-05-06
KR890000762B1 (ko) 1989-04-05
ES8308570A1 (es) 1983-09-16
AU552353B2 (en) 1986-05-29
EP0074101B1 (en) 1985-04-03
US4542210A (en) 1985-09-17
GB2108964A (en) 1983-05-25

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19970908