GB2088864B - Doxycycline monosodium tetrametaphosphate complexes and their preparation - Google Patents

Doxycycline monosodium tetrametaphosphate complexes and their preparation

Info

Publication number
GB2088864B
GB2088864B GB8135611A GB8135611A GB2088864B GB 2088864 B GB2088864 B GB 2088864B GB 8135611 A GB8135611 A GB 8135611A GB 8135611 A GB8135611 A GB 8135611A GB 2088864 B GB2088864 B GB 2088864B
Authority
GB
United Kingdom
Prior art keywords
tetrametaphosphate
doxycycline
monosodium
complexes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8135611A
Other languages
English (en)
Other versions
GB2088864A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB2088864A publication Critical patent/GB2088864A/en
Application granted granted Critical
Publication of GB2088864B publication Critical patent/GB2088864B/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/04—Sodium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB8135611A 1980-11-25 1981-11-25 Doxycycline monosodium tetrametaphosphate complexes and their preparation Expired GB2088864B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT72107A PT72107B (fr) 1980-11-25 1980-11-25 Procede de preparation d'un complexe hydrosoluble de alpha-6-dioxi-5-hydroxitetracycline et de tetrametaphosphate desodium

Publications (2)

Publication Number Publication Date
GB2088864A GB2088864A (en) 1982-06-16
GB2088864B true GB2088864B (en) 1984-09-12

Family

ID=20082809

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8135611A Expired GB2088864B (en) 1980-11-25 1981-11-25 Doxycycline monosodium tetrametaphosphate complexes and their preparation

Country Status (13)

Country Link
JP (1) JPS57116033A (es)
KR (1) KR860000450B1 (es)
AU (1) AU543041B2 (es)
BE (1) BE891236A (es)
DE (1) DE3146279A1 (es)
ES (1) ES8302629A1 (es)
FR (1) FR2494685A1 (es)
GB (1) GB2088864B (es)
HK (1) HK10687A (es)
NL (1) NL190067C (es)
PH (1) PH20236A (es)
PT (1) PT72107B (es)
ZA (1) ZA817804B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8415331B2 (en) 2003-07-25 2013-04-09 Warner Chilcott Company, Llc Doxycycline metal complex in a solid dosage form

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5538954A (en) * 1994-06-24 1996-07-23 A/S Dumex (Dumex Ltd.) Salts of tetracyclines

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1068701B (de) * 1959-11-12 Bristol Laboratories Inc., East Syracuse, N. Y. (V. St. A.) Verfahren zur Herstellung von antibiotisch wirksamem Tetracyclinnatriumhexametaphosphat
BE568762A (es) *
US2791609A (en) * 1956-09-27 1957-05-07 Murray A Kaplan Tetracycline metallo-phosphate complexes and method preparation
US2795528A (en) * 1956-10-24 1957-06-11 Frank H Buckwalter Therapeutic composition containing a tetracycline and a phosphate other than orthophosphate
US3053892A (en) * 1960-04-27 1962-09-11 American Cyanamid Co Metaphosphoric acid complexes of tetracycline and its analogs
US3068264A (en) * 1961-06-06 1962-12-11 American Cyanamid Co Tetracycline antibiotic-aluminumphosphoric acid complexes
GB1180701A (en) * 1967-06-23 1970-02-11 Pfizer & Co C Process for Purifying Tetracycline Antibiotics with Phosphate Salts
ES396132A1 (es) * 1970-10-30 1972-12-01 Villax Proceso de preparacion de los complejos del acido metafos- forico de la alfa-6-deoxi-5-hidroxitetraciclina y las sales alcali-metalicas de los mismos.
JPS5745215A (en) * 1980-09-01 1982-03-15 Toshiba Corp Molding device of iron plate for wound core

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8415331B2 (en) 2003-07-25 2013-04-09 Warner Chilcott Company, Llc Doxycycline metal complex in a solid dosage form

Also Published As

Publication number Publication date
JPS57116033A (en) 1982-07-19
FR2494685B1 (es) 1985-02-01
PT72107A (fr) 1980-12-01
GB2088864A (en) 1982-06-16
BE891236A (fr) 1982-05-24
ZA817804B (en) 1982-12-29
NL8105309A (nl) 1982-06-16
FR2494685A1 (fr) 1982-05-28
DE3146279A1 (de) 1982-08-19
ES507293A0 (es) 1983-02-01
NL190067B (nl) 1993-05-17
AU543041B2 (en) 1985-03-28
NL190067C (nl) 1993-10-18
ES8302629A1 (es) 1983-02-01
HK10687A (en) 1987-02-06
PT72107B (fr) 1981-10-28
KR830007076A (ko) 1983-10-14
PH20236A (en) 1986-11-10
AU7761281A (en) 1982-06-03
KR860000450B1 (ko) 1986-04-26

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Effective date: 20011124