GB2031395A - Synthetic magnesium aluminosilicate - Google Patents

Synthetic magnesium aluminosilicate Download PDF

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Publication number
GB2031395A
GB2031395A GB7930962A GB7930962A GB2031395A GB 2031395 A GB2031395 A GB 2031395A GB 7930962 A GB7930962 A GB 7930962A GB 7930962 A GB7930962 A GB 7930962A GB 2031395 A GB2031395 A GB 2031395A
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Prior art keywords
magnesium aluminosilicate
composition
magnesium
aqueous solution
precipitate
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GB2031395B (en
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OM LAB SA
Laboratoires OM SA
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OM LAB SA
Laboratoires OM SA
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Priority claimed from CH589079A external-priority patent/CH639630A5/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B33/00Silicon; Compounds thereof
    • C01B33/20Silicates
    • C01B33/26Aluminium-containing silicates, i.e. silico-aluminates

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Description

1 GB 2 031 395. A.1
SPECIFICATION
Synthetic magnesium aluminosilicate, process for the manufacture thereof, and pharmaceutical compositions containing same This invention relates to a synthetic magnesium aluminosilicate, to a process for the manufacture 5 thereof, and to pharmaceutical compositions containing this product.
Synthetically produced magnesium aluminosilicates, which are used particularly for medical purposes, and processes fortheir manufacture, are known. The criteria applicable for defining an advantageously usable product are essentially: as large a specific surface as possible, good antacid action, and high adsorbency. A process of the type in question for manufacturing a magnesium 10aluminosilicate is described, for example, in the specification of U.K. Patent No. 1,385,158.
However, there is a need for a magnesium aluminosilicate having a welldefined composition which can be manufactured by a simPleprocess hitherto undisclosed and which possesses very good therapeutic properties.
According to the present invention, there is provided a magnesium aluminosilicate characterized in that it substantially comprises, by weight, 47-57% Si021 9-11% A1A, 3- 5% MgO, 1-3% CaO, 15 and <5% Na20, calculated analytically.
The composition thereof is comparable to that of natural clays of the palygorskite family. It presents the advantage of being a chemically and physically well-defined synthesis product. It is thus a mineral compound and not a physical mixture of magnesium silicate and aluminium silicate.
Its amorphous state finds its expression in an absence of organized structure on the crystal scale 20 and yields a spectrum of X-ray diffraction which does not exhibit any characteristic line.
There is also provided according to the present invention a process for manufacturing the foregoing magnesium aluminosilicate, characterized by stirring into a first aqueous solution, containing the corresponding amounts of magnesium sulfate and aluminium sulfate, a second aqueous solution, containing sodium silicate and sodium hydroxide, thereafter adding a third aqueous solution containing 25 a corresponding amount of calcium chloride, continuing the stirring, filtering off and washing the precipitate, and drying the precipitate at a temperature below 1 001C, or, instead of adding the third aqueous solution containing calcium chloride, by using lime water in the manufacturing process and for washing.
Preferred embodiments of the process according to the invention will now be described in detail, 30 purely by way of example and without implying any limitation of the invention thereto.
In a 1 000-litre stainless steel vat, 30.76 kg of pharmaceutical-grade magnesium sulfate is completely dissolved in 100 litres of lukewarm purified water, the temperature being maintained between 300 and 401C.
The liquid is then filtered in order to obtain a perfectly clear solution, free of impurities. To this 35 solution there is added 97.5 litres of an aqueous solution of pharmaceutical-grade aluminium sulfate (A1203 content = 8%). The whole mixture is homogenized by vigorous stirring, the temperature being kept between 30' and 4WC.
A second solution is also prepared by mixing 182 kg of sodium silicate (S'02 content = 27.5%), previously filtered, 25 litres of pharmaceutical-grade caustic soda lye (NaOH content = 48%), and 100 40 litres of purified water.
This second solution is added slowly into the first stirred solution with slow heating to a temperature of 60-651C.
Furthermore, 7.8 kg of crystallized pharmaceutical calcium chloride is completely dissolved in 10 litres of lukewarm purified water. The solution is then filtered to obtain a perfectly clear solution which is 45 thereupon added slowly to the mixture, and the latter is then stirred vigorously for about one hour until a homogeneous mixture having a pH of close to 9 is obtained, the pH being taken about every 10 minutes. The resultant precipitate is filtered off in a filter press or a rotary vacuum filter, then washed in copious amounts of water for about 14 hou rs.
The speed of stirring during precipitation determines the physical texture of the product. 50 Adherence to the specified temperatures makes it possible to obtain the physico-che mica 1 properties.
The precipitate is then dried very gently at the lowest possible temperature, in any case not above 1 OOOC, so as to comprise about 28-32% water by weight.
It has been found that instead of introducing calcium in the form of calcium chloride, it is likewise possible to add calcium together with the water used in the manufacturing process and for washing. For 55 9 example, by using 10,000 litres of lime water having a calcic ion content of, e.g., 0.01 %, it is possible to obtain a CaO content of about 1.4%, analytically calculated, in the end product.
The product obtained by one of the above-mentioned processes is then crushed by means of successive passes through a hammer mill.
The resultant yield is about 95 kg of fine powder, the analytical composition of which is as follows: 60 51 % S'021 10% A120,4% MgO, 2% CaO, and 1 % Na,O, analytically calculated.
Crushing is preferably carried out in such a way that 99% of the powder passes a 1 00-micron sieve (ASTM 140) and 95% passes a 63-micron sieve (ASTMI 215).
An aqueous suspension of 5 g of the powder in 50 mi of distilled water has a pH of 8-10, while 2 GB 2 031 395 A calcination at 8000C leads to a weight loss of about 28-32%.
The resultant product in powder form has a very large specific surface, good antacid action, and high adsorbency, which makes this product particularly suitable for pharmaceutical use in the treatment of gastric and intestinal ailments. The product may either be used alone as a medicinal remedy or be treated to take any desired galenical form known perse for this use. The magnesium aluminosilicate 5 according to the invention may, in the usual manner, be formulated with the aid of additives such as binding agents, viscosity-increasing agents, gelling agents, antifoaming agents such as dimethyl polysiloxane (Dim6ticone, DCO, aromatic substances, and similar substances, to take the form of tablets, powder, granules, or a gel.
One particularly advantageous form of preparation for oral administration is an aqueous gel which 10 may be produced by combining conventional gel-forming substances, such as carboxymethyl cellulose, and the aromatic substances, and adding about 30% of the magnesium aluminosilicate according to the invention. An example of the manufacture of such a gel will now be described in more detail.
Manufacture of a preparation in accordance with the invention, in the form of a gel Starting materials for a 300-kg batch Magnesium aluminosilicate according to the invention Saccharose Sodium carboxymethyl cellulose Preservatives Aromatic composition Ethanol Demineraiized water kg 32 kg 1.5 kg 0.5 kg 33 g 1.2 kg q.s. for 300 kg Manufacture takes place in a vat equipped with a mixer and a homogenizer. The saccharose is dissolved, with stirring, in 160 litres of demineralized water. After filtration, the preservatives are added, 25 and the contents of the vat are brought to a boil for 5 minutes. After cooling, the carboxymethyl cellulose is added, and mixing is carried out until complete dispersion is obtained. The magnesium aluminosilicate according to the invention is then added, the mixture is heated to 901C for 1 hour, and stirring is continued for 30 minutes. The result is a gel which is placed in single-dose packets or in bottles, the usual dosage being from 10 to 60 g of gel per day for an adult.
As alreiady_ mentioned, the magnesium aluminosilicate according to the invention may equally well take otherforms of galenical preparations, particularly those of tablets, powder, or granules.
The therapeutic value of the product according to the invention is determined by its physicochemical characteristics, i.e., by: (a) a very large specific surface resulting in a protectant effect similar to that of bismuth salts used therapeutically, (b) good antacid action, i.e., a rapid neutralizing effect and prolonged buffering action, (c) high adsorbent capacity.
These physico-che mica I properties, compared with those of commercially available prior art _ products, are set forth in the following Table 1.
11 -4 0 3 GB 2 031 395 A 3 Table 1
Product Specific Neutralizing Adsorbent capacity Dispersing surface capacity at 37 1 capacity M21g mi AN HCl/g mg methylene blue/g % 1. Magnesium aluminosilicate according to the invention (powder) 410 85 109 92 2. Commercially available pro duct (natural magnesium aluminosilicate, powder) 94 42 107 74 3. Commercially available pro duct containing bismuth (powder) 5 6 25 45 As may be seen, the physico-chemical properties of the compound according to the present invention are superior to those of the other specialities examined.
Moreover, the neutralizing effect and the buffer capacity in a gastric medium have been the 5 subject of in vitro tests.
According to Schnekenburger, an antacid is a good gastric neutralizer when the reaction time for attaining a pH of 3.0 is less than one minute, and when the duration of the action, i.e., the period during which the pH remains above 3.0, is at least 45 minutes. The duration of the action is also called the -buffer effect."
The tests have shown that the initial rise of the pH to 3.0 is very rapid with the compound 10 according to the invention at a concentration of close to 3 g. Among seven other substances (commercially available products) examined, only one raises the pH to 3.0 in less than one minute. The duration of the action of the compound according to the invention is comparable to that of product 2 in Table 1. The buffer effect of the other products used is clearly inferior.
Based upon the aforementioned advantageous properties, the preparation according to the 15 invention is suitable for application in the following fields:
Gastric pathology: gastritis, gastric and duodenal ulcers, reflux oesophagitis, hiatus hernia, pregnancy pyrosis, hyperchlorhydria, dyspepsia with meteorism.
Intestinal pathology: diarrhoea of any etiology in adults and children, intestinal fermentation, colitic syndrome with fermentation.
Owing to its low toxicity, the product may be used in paediatrics.
Toxicity studies Studies of acute, subacute, and chronic toxicity carried out on rats and dogs, 3 months p.o., showed excellent tolerance of the product. No toxic effect could be detected, even at high dosages.
Pharmacological properties In order to check the pharmacological properties of the product, a study of these protective properties was carried out on experimental ulcers induced by means of a hyperglycemic diet.
Forty male Sprague-Dawiey rats, weighing from 350 to 380 grams, were divided into four groups of 10 animals each and subjected for 10 days to the high-glucose diet. On the eleventh day, the animals were put to death and their stomachs removed. After the oesophageal portion had been ligatured, the stomachs were emptied and cut open along the lesser curvature, then spread out on a slab of cork. Each stomach was classified from 1 to 3: (0) no ulcer, (1) one to two ulcers, (2) three or four ulcers, and (3) more than four ulcers.
4 GB 2 031 395 A 4 Table 2
Number of stomachs Group Number classified of rats TO, 2 Control 10 0 1 0 Compound No. 2 of Table 1 9 0 6 1 Compound according to invention (powder) 9 5 4 0 Composition according to invention (gel) 10 8 2 0 3 9 2 0 0 Average % of rats Index classi- having an of fication ulcer ulcer 2.8 100 280 - 1.56 100 156 0.44 44 196 0.2 20 4 Total of classificationt>.x% of stomachs having an ulcer number of animals Conclusion: In the test on glucose-induced ulcers in rats, the compound according to the invention (gel) proved to be much more effective than the reference product (compound No. 2 of Table 1) and slightly more effective than the active substance in suspension in distilled water.
It has been possible to confirm by means of clinical tests the advantageous properties established in the foregoing tests carried out on animals. The product acts quickly to combat pain and pyrosis, and 5 its activity is remarkable in the case of ulcers, gastritis, and oesophagitis. The product is very well tolerated.
Clinical studies In clinical pharmacology, gastric pH measurements were taken with the Heidelberg capsule by means of continuous telemetric recording. Eleven patients suffering from various gastric ailments were 10 analyzed. The average basal pH was 1. 16. After administration of 10 g of gel, the maximum pH was, on an average, 4.6. The average time required to reach the maximum pH was 5. 7 minutes. The average duration of action, until return to the basa I pH, was 29.6 minutes.
Five clinical studies relating to 171 cases demonstrate the therapeutic value of the product according to the invention.
Sixty-nine patients suffering from various gastric complaints (duodenal ulcer, gastric ulcer, gastritis, esophagitis, dyspepsia) were treated for 2 to 3 months with the product according to the invention in gel form, at the rate of 4-6 1 0-gram packets of gel per day. The product acted rapidly to combat pain and pyrosis. Its activity was remarkable in the case of ulcers, gastritis, and esophagitis. The product was very well tolerated, and its taste was well accepted.
Another group of 40 patients suffering from various gastric complaints was treated for 30 days at the rate of 3-4 1 0-gram packets per day of gel according to the invention. The results were excellent or good in 75% of the cases. Only 10% (four cases) were judged nil. The improvement was noted above all in connection with such symptoms as pyrosis, distention, and pain. Tolerance was excellent.
Twenty cases of diarrhoea of varied etiology were treated at the same dosage for 14 days. The 25 results were good in 80% of the cases and nil in 10%. Tolerance was excellent. Of 16 patients who commented, 13 considered the product better than previous medication, and 3 found it to be equivalent.
In a fourth group (116 cases treated), the results were as follows: 13 excellent, 2 good, 1 nil. The product was considered excellent both as to its action at the gastric level and as to tolerance. The 30 patients found the taste agreeable. In general, the patient considered the product superior to previous medication.
Twenty-six patients were treated for gastric indications. The results were 15 excellent, 9 good, and 2 fair. There were no failures of the medication. Subjective relief of pain was very rapid: on an 3Ei average in the 26 cases, 8.4 minutes after ingestion.
7 GB 2 031 395 A 5

Claims (14)

1. Synthetic magnesium aluminosilicate substantially comprising, by weight, 47-57% S'021 9-11% A1203,3-5% MgO, 1-3% CaO, and <5% Na20, calculated analytically.
described.
described.
2. A process for manufacturing the magnesium aluminosilicate of claim 1, comprising the steps of stirring into a first aqueous solution, containing the corresponding amounts of magnesium sulfate 5 and aluminium sulfate, a second aqueous solution containing sodium silicate and sodium hydroxide, thereafter adding a third aqueous solution containing a corresponding amount of calcium chloride, continuing the stirring, filtering off and washing the precipitate, and drying the precipitate at a temperature below 1 001C, or, instead of adding the third aqueous solution containing calcium chloride, by using lime water in the manufacturing process and for washing.
3. A pharmaceutical composition having antacid action and high adsorbency, containing a magnesium aluminosilicate according to claim 1 as the active substance.
4. A composition in accordance with claim 3 for oral administration in the form of an aqueous gel. 15
5. A composition in accordance with claim 3 for oral administration in the form of tablets, powder, or granules.
6. A composition in accordance with claim 3 for oral administration, comprising dimethyl polysiloxane in combination with the magnesium aluminosilicate according to claim 1.
7. Synthetic magnesium aluminosilicate as hereinbefore described.
8. Magnesium aluminosilicate produced.by a process according to claim 2.
9. A process for manufacturing magnesium aluminosilicate substantially as hereinbefore
10. A pharmaceutical composition containing magnesium aluminosilicate as hereinbefore
11. Any novel feature or combination of features disclosed herein.
12. A process according to claim 2 wherein the sodium silicate solution is added slowly to a vigorously agitated solution of aluminium and magnesium sulfates, with slow heating of the resultant solution to a temperature of 60-651C, the resultant mixture is agitated vigorously and the precipitate 30 is collected when the pH of the mixture is about 9.
13. Synthetic magnesium aluminosilicate according to claim 1 wherein the balance of the analysis is substantially volatile materials (as determined by loss on calcination at 800IC).
14. Synthetic magnesium aluminosilicate according to claim 13 wherein the volatile materials comprise 28 to 32% by weight of the composition.
Printed for Her Majesty's Stationery Office by the Courier Press, Leamington Spa, 1980. Published by the Patent Office. 25 Southampton Buildings, London, WC2A 'I AY, from which copies may be obtained.
GB7930962A 1978-09-07 1979-09-06 Synthetic magnesium aluminosilicate Expired GB2031395B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH938478 1978-09-07
CH589079A CH639630A5 (en) 1979-06-22 1979-06-22 Synthetic magnesium aluminium silicate, process for its manufacture and pharmaceutical compositions comprising it

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GB2031395A true GB2031395A (en) 1980-04-23
GB2031395B GB2031395B (en) 1982-10-13

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AR (1) AR221103A1 (en)
DD (1) DD145740A5 (en)
DE (1) DE2936078C2 (en)
ES (1) ES484103A1 (en)
FR (1) FR2435442A1 (en)
GB (1) GB2031395B (en)
HU (1) HU180034B (en)
IT (1) IT1198313B (en)
PL (1) PL117242B1 (en)
PT (1) PT70125A (en)
RO (1) RO78238A (en)
YU (1) YU41174B (en)

Cited By (6)

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Publication number Priority date Publication date Assignee Title
GB2164636A (en) * 1984-08-24 1986-03-26 British Petroleum Co Plc Synthetic smectites and their stabilised pillared analogues
US7799351B2 (en) 1997-09-19 2010-09-21 Ineos Healthcare Limited Metal compounds, mixed or sulphated, as phosphate binders
US9066917B2 (en) 2009-08-03 2015-06-30 Cytochroma Development Inc. Mixed metal compound
US9168270B2 (en) 2006-01-31 2015-10-27 Opko Ireland Global Holdings, Ltd. Water-insoluble, iron-containing mixed metal, granular material
US10155040B2 (en) 2007-10-16 2018-12-18 Opko Ireland Global Holdings, Ltd. Mixed metal compounds for treatment of hyperphosphataemia
US10201501B2 (en) 2007-07-27 2019-02-12 Opko Ireland Global Holdings, Ltd. Mixed metal compounds used as antacids

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US4745092A (en) * 1987-04-27 1988-05-17 The Dow Chemical Company Strengthened cordierite having minor amounts of calcia
FR2639148B1 (en) * 1988-11-16 1991-08-02 Merlin Gerin MAGNETIC TRIGGER WITH WIDE TRIGGER THRESHOLD ADJUSTMENT RANGE
US6358365B1 (en) * 1999-12-14 2002-03-19 Hercules Incorporated Metal silicates, cellulose products, and processes thereof
US20070154603A1 (en) * 2005-12-30 2007-07-05 Withiam Michael C Treatment of cooking oils and fats with sodium magnesium aluminosilicate materials
GB201001779D0 (en) 2010-02-04 2010-03-24 Ineos Healthcare Ltd Composition
US9849200B2 (en) 2010-09-16 2017-12-26 Mo-Sci Corporation Strontium phosphate microparticle for radiological imaging and therapy
US9119887B2 (en) 2010-09-16 2015-09-01 Mo-Sci Corporation Low-density magnesium-aluminum-silicate (MAS) microparticles for radiotherapy and/or radioimaging
US8865123B1 (en) 2010-09-16 2014-10-21 Mo-Sci Corporation Strontium phosphate microparticle for radiological imaging and therapy
JP7382331B2 (en) * 2018-02-02 2023-11-16 ダブリュー・アール・グレース・アンド・カンパニー-コーン Antacid for polymers

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FR1330121A (en) * 1959-07-22 1963-06-21 Mallinckrodt Chemical Works Improvements to processes for preparing double aluminum and magnesium silicates
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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2164636A (en) * 1984-08-24 1986-03-26 British Petroleum Co Plc Synthetic smectites and their stabilised pillared analogues
US7799351B2 (en) 1997-09-19 2010-09-21 Ineos Healthcare Limited Metal compounds, mixed or sulphated, as phosphate binders
US8568792B2 (en) 1997-09-19 2013-10-29 Cytochroma Development Inc. Metal compounds, mixed or sulphated, as phosphate binders
US9242869B2 (en) 1997-09-19 2016-01-26 Opko Ireland Global Holdings, Ltd. Metal compounds mixed or sulphated, as phosphate binders
US9168270B2 (en) 2006-01-31 2015-10-27 Opko Ireland Global Holdings, Ltd. Water-insoluble, iron-containing mixed metal, granular material
US9907816B2 (en) 2006-01-31 2018-03-06 Opko Ireland Global Holdings, Ltd. Water-insoluble, iron-containing mixed metal, granular material
US10201501B2 (en) 2007-07-27 2019-02-12 Opko Ireland Global Holdings, Ltd. Mixed metal compounds used as antacids
US10155040B2 (en) 2007-10-16 2018-12-18 Opko Ireland Global Holdings, Ltd. Mixed metal compounds for treatment of hyperphosphataemia
US9066917B2 (en) 2009-08-03 2015-06-30 Cytochroma Development Inc. Mixed metal compound
US9314481B2 (en) 2009-08-03 2016-04-19 Opko Ireland Global Holdings, Ltd. Method

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Publication number Publication date
IT1198313B (en) 1988-12-21
GB2031395B (en) 1982-10-13
YU41174B (en) 1986-12-31
FR2435442B1 (en) 1983-07-29
DE2936078C2 (en) 1982-03-11
DE2936078A1 (en) 1980-03-20
RO78238A (en) 1982-04-12
DD145740A5 (en) 1981-01-07
HU180034B (en) 1983-01-28
AR221103A1 (en) 1980-12-30
IT7925088A0 (en) 1979-08-13
YU204779A (en) 1984-02-29
US4339421A (en) 1982-07-13
PL117242B1 (en) 1981-07-31
PT70125A (en) 1979-09-01
PL218133A1 (en) 1980-06-02
FR2435442A1 (en) 1980-04-04
ES484103A1 (en) 1980-04-16

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Effective date: 19980906