GB201818816D0 - Regulatory nucleic acid sequences - Google Patents

Regulatory nucleic acid sequences

Info

Publication number
GB201818816D0
GB201818816D0 GBGB1818816.9A GB201818816A GB201818816D0 GB 201818816 D0 GB201818816 D0 GB 201818816D0 GB 201818816 A GB201818816 A GB 201818816A GB 201818816 D0 GB201818816 D0 GB 201818816D0
Authority
GB
United Kingdom
Prior art keywords
nucleic acid
acid sequences
regulatory nucleic
regulatory
sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1818816.9A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AskBio UK Ltd
Original Assignee
Synpromics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synpromics Ltd filed Critical Synpromics Ltd
Priority to GBGB1818816.9A priority Critical patent/GB201818816D0/en
Publication of GB201818816D0 publication Critical patent/GB201818816D0/en
Priority to EP19809588.7A priority patent/EP3883952A1/en
Priority to PCT/GB2019/053267 priority patent/WO2020104782A1/en
Priority to AU2019382955A priority patent/AU2019382955B2/en
Priority to JP2021527948A priority patent/JP7489161B2/ja
Priority to CA3120253A priority patent/CA3120253A1/en
Priority to CN201980089303.6A priority patent/CN113454104A/zh
Priority to PCT/GB2019/053268 priority patent/WO2020104783A1/en
Priority to EP19809587.9A priority patent/EP3883951A1/en
Priority to US17/295,210 priority patent/US12630595B2/en
Priority to US17/295,208 priority patent/US12590129B2/en
Priority to IL283219A priority patent/IL283219A/en
Priority to JP2024075266A priority patent/JP7860164B2/ja
Priority to AU2025287323A priority patent/AU2025287323A1/en
Priority to JP2026075526A priority patent/JP2026124829A/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GBGB1818816.9A 2018-11-19 2018-11-19 Regulatory nucleic acid sequences Ceased GB201818816D0 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
GBGB1818816.9A GB201818816D0 (en) 2018-11-19 2018-11-19 Regulatory nucleic acid sequences
US17/295,208 US12590129B2 (en) 2018-11-19 2019-11-19 Liver-specific regulatory nucleic acid sequences
CN201980089303.6A CN113454104A (zh) 2018-11-19 2019-11-19 肝特异性调节性核酸序列
EP19809587.9A EP3883951A1 (en) 2018-11-19 2019-11-19 Liver-specific regulatory nucleic acid sequences
AU2019382955A AU2019382955B2 (en) 2018-11-19 2019-11-19 Liver-specific regulatory nucleic acid sequences
JP2021527948A JP7489161B2 (ja) 2018-11-19 2019-11-19 肝臓特異的調節性核酸配列
CA3120253A CA3120253A1 (en) 2018-11-19 2019-11-19 Liver-specific regulatory nucleic acid sequences
EP19809588.7A EP3883952A1 (en) 2018-11-19 2019-11-19 Regulatory nucleic acid sequences
PCT/GB2019/053268 WO2020104783A1 (en) 2018-11-19 2019-11-19 Regulatory nucleic acid sequences
PCT/GB2019/053267 WO2020104782A1 (en) 2018-11-19 2019-11-19 Liver-Specific Regulatory Nucleic Acid Sequences
US17/295,210 US12630595B2 (en) 2018-11-19 2019-11-19 Regulatory nucleic acid sequences
IL283219A IL283219A (en) 2018-11-19 2021-05-16 Liver-specific regulatory nucleic acid sequences
JP2024075266A JP7860164B2 (ja) 2018-11-19 2024-05-07 肝臓特異的調節性核酸配列
AU2025287323A AU2025287323A1 (en) 2018-11-19 2025-12-24 Liver-Specific Regulatory Nucleic Acid Sequences
JP2026075526A JP2026124829A (ja) 2018-11-19 2026-04-28 肝臓特異的調節性核酸配列

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1818816.9A GB201818816D0 (en) 2018-11-19 2018-11-19 Regulatory nucleic acid sequences

Publications (1)

Publication Number Publication Date
GB201818816D0 true GB201818816D0 (en) 2019-01-02

Family

ID=64740036

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1818816.9A Ceased GB201818816D0 (en) 2018-11-19 2018-11-19 Regulatory nucleic acid sequences

Country Status (9)

Country Link
US (2) US12590129B2 (enExample)
EP (2) EP3883951A1 (enExample)
JP (3) JP7489161B2 (enExample)
CN (1) CN113454104A (enExample)
AU (2) AU2019382955B2 (enExample)
CA (1) CA3120253A1 (enExample)
GB (1) GB201818816D0 (enExample)
IL (1) IL283219A (enExample)
WO (2) WO2020104783A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021207526A1 (en) 2020-04-09 2021-10-14 The Regents Of The University Of California Humanized notch receptors with hinge domain
KR102726511B1 (ko) 2021-01-20 2024-11-07 주식회사 큐로젠 Ssu72 단백질 또는 Ssu72 단백질을 코딩하는 뉴클레오티드를 포함하는 간암 예방 또는 치료용 약학적 조성물
AU2022214501B2 (en) 2021-01-29 2025-05-22 Curogen Technology Co., Ltd. Pharmaceutical composition for treating liver diseases using ssu72
WO2023008925A1 (ko) * 2021-07-29 2023-02-02 주식회사 리보퓨틱스 융합 프로모터, 이를 포함하는 재조합 벡터 및 이를 이용하는 간암 치료용 조성물
JP2026516710A (ja) * 2023-04-20 2026-05-26 アスクバイオ インコーポレイテッド 肝臓特異的調節核酸配列
CN116555266B (zh) * 2023-06-09 2024-11-12 呈诺再生医学科技(北京)有限公司 肝脏特异性表达的重组启动子和载体及其在肝脏相关疾病治疗中的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5721096A (en) * 1991-01-24 1998-02-24 Children's Medical Center Corporation Methods of screening for compounds with ability to alter apolipoprotein AI gene expression
US5578444A (en) 1991-06-27 1996-11-26 Genelabs Technologies, Inc. Sequence-directed DNA-binding molecules compositions and methods
US6268212B1 (en) 1993-10-18 2001-07-31 Amgen Inc. Tissue specific transgene expression
EP0933997A4 (en) 1996-09-06 2000-08-16 Chiron Corp METHODS AND COMPOSITIONS FOR LIVER-SPECIFIC ADMINISTRATION OF THERAPEUTIC MOLECULES USING RECOMBINANT AAV VECTORS
US7351813B2 (en) 2000-06-20 2008-04-01 The Board Of Trustees Of The Leland Stanford Junior University Liver-specific gene expression cassettes, and methods of use
WO2002092134A1 (en) 2001-05-14 2002-11-21 Cell Genesys, Inc. Lentiviral vectors encoding clotting factors for gene therapy
CN102634515B (zh) 2008-02-14 2013-11-06 财团法人牧岩生命工学研究所 适于表达用于基因治疗的编码序列的表达载体
CN102628041B (zh) 2008-02-14 2013-09-11 财团法人牧岩生命工学研究所 适于表达用于基因治疗的编码序列的表达载体
US9617548B2 (en) 2008-04-22 2017-04-11 Vib Vzw Liver-specific nucleic acid regulatory elements and methods and use thereof
US8815779B2 (en) 2009-09-16 2014-08-26 SwitchGear Genomics, Inc. Transcription biomarkers of biological responses and methods
EP2479278A1 (en) 2011-01-25 2012-07-25 Synpromics Ltd. Method for the construction of specific promoters
JP6879486B2 (ja) * 2015-03-17 2021-06-02 フリーイェ・ユニヴェルシテイト・ブリュッセルＶｒｉｊｅ Ｕｎｉｖｅｒｓｉｅｉｔ Ｂｒｕｓｓｅｌ Ｆｖｉｉｉおよびｆｉｘ用の最適化された肝臓特異的発現系
PE20181922A1 (es) 2016-04-15 2018-12-11 Univ Pennsylvania Terapia genica para tratar la hemofilia a
WO2018144709A2 (en) 2017-02-01 2018-08-09 The Trustees Of The University Of Pennsylvania Gene therapy for treating citrullenemia
BR112019024608A2 (pt) 2017-05-24 2020-06-23 Universitat Autonoma De Barcelona Construto de expressão viral que compreende uma sequência de codificação do fator de crescimento de fibroblastos 21 (fgf21)
JP2020533971A (ja) 2017-08-28 2020-11-26 アルター・バイオサイエンス・コーポレーション Ｉｌ−１５をベースとするｉｌ−７及びｉｌ−２１への融合物
CN108588097B (zh) 2018-04-28 2021-07-13 北京锦篮基因科技有限公司 改造后的hbv基因组和相关组合物及其应用

Also Published As

Publication number Publication date
JP2024096349A (ja) 2024-07-12
JP2022507828A (ja) 2022-01-18
JP7489161B2 (ja) 2024-05-23
CN113454104A (zh) 2021-09-28
AU2019382955B2 (en) 2025-09-25
US12630595B2 (en) 2026-05-19
CA3120253A1 (en) 2020-05-28
EP3883951A1 (en) 2021-09-29
US12590129B2 (en) 2026-03-31
JP2026124829A (ja) 2026-07-31
WO2020104782A1 (en) 2020-05-28
AU2025287323A1 (en) 2026-03-26
JP7860164B2 (ja) 2026-05-15
IL283219A (en) 2021-06-30
US20210388347A1 (en) 2021-12-16
EP3883952A1 (en) 2021-09-29
AU2019382955A1 (en) 2021-06-10
WO2020104783A1 (en) 2020-05-28
US20220009981A1 (en) 2022-01-13

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)