GB201804860D0 - CD47 Binding agents - Google Patents

CD47 Binding agents

Info

Publication number
GB201804860D0
GB201804860D0 GBGB1804860.3A GB201804860A GB201804860D0 GB 201804860 D0 GB201804860 D0 GB 201804860D0 GB 201804860 A GB201804860 A GB 201804860A GB 201804860 D0 GB201804860 D0 GB 201804860D0
Authority
GB
United Kingdom
Prior art keywords
binding agents
binding
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1804860.3A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ultrahuman Two Ltd
Original Assignee
Ultrahuman Two Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ultrahuman Two Ltd filed Critical Ultrahuman Two Ltd
Priority to GBGB1804860.3A priority Critical patent/GB201804860D0/en
Publication of GB201804860D0 publication Critical patent/GB201804860D0/en
Priority to GBGB1813693.7A priority patent/GB201813693D0/en
Priority to KR1020267004860A priority patent/KR20260036010A/ko
Priority to JP2020552716A priority patent/JP7458569B2/ja
Priority to CA3093777A priority patent/CA3093777A1/en
Priority to PCT/EP2019/057723 priority patent/WO2019185717A1/en
Priority to AU2019246401A priority patent/AU2019246401B2/en
Priority to IL277343A priority patent/IL277343B1/en
Priority to US17/041,100 priority patent/US12421310B2/en
Priority to CN201980021901.XA priority patent/CN111936515B/zh
Priority to EP19715427.1A priority patent/EP3774886A1/en
Priority to KR1020207029435A priority patent/KR102929571B1/ko
Priority to SG11202008965SA priority patent/SG11202008965SA/en
Priority to US19/192,994 priority patent/US20260015420A1/en
Priority to AU2026200633A priority patent/AU2026200633A1/en
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
GBGB1804860.3A 2018-03-27 2018-03-27 CD47 Binding agents Ceased GB201804860D0 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
GBGB1804860.3A GB201804860D0 (en) 2018-03-27 2018-03-27 CD47 Binding agents
GBGB1813693.7A GB201813693D0 (en) 2018-03-27 2018-08-22 CD47 binding agents
SG11202008965SA SG11202008965SA (en) 2018-03-27 2019-03-27 Cd47 binding agents
AU2019246401A AU2019246401B2 (en) 2018-03-27 2019-03-27 CD47 binding agents
CN201980021901.XA CN111936515B (zh) 2018-03-27 2019-03-27 Cd47结合剂
CA3093777A CA3093777A1 (en) 2018-03-27 2019-03-27 Cd47 binding agents
PCT/EP2019/057723 WO2019185717A1 (en) 2018-03-27 2019-03-27 Cd47 binding agents
KR1020267004860A KR20260036010A (ko) 2018-03-27 2019-03-27 Cd47 결합제
IL277343A IL277343B1 (en) 2018-03-27 2019-03-27 "CD47-binding factors and their uses in the treatment of diseases"
US17/041,100 US12421310B2 (en) 2018-03-27 2019-03-27 CD47 binding agents
JP2020552716A JP7458569B2 (ja) 2018-03-27 2019-03-27 Cd47結合剤
EP19715427.1A EP3774886A1 (en) 2018-03-27 2019-03-27 Cd47 binding agents
KR1020207029435A KR102929571B1 (ko) 2018-03-27 2019-03-27 Cd47 결합제
US19/192,994 US20260015420A1 (en) 2018-03-27 2025-04-29 Cd47 binding agents
AU2026200633A AU2026200633A1 (en) 2018-03-27 2026-01-29 Cd47 binding agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1804860.3A GB201804860D0 (en) 2018-03-27 2018-03-27 CD47 Binding agents

Publications (1)

Publication Number Publication Date
GB201804860D0 true GB201804860D0 (en) 2018-05-09

Family

ID=62068079

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB1804860.3A Ceased GB201804860D0 (en) 2018-03-27 2018-03-27 CD47 Binding agents
GBGB1813693.7A Ceased GB201813693D0 (en) 2018-03-27 2018-08-22 CD47 binding agents

Family Applications After (1)

Application Number Title Priority Date Filing Date
GBGB1813693.7A Ceased GB201813693D0 (en) 2018-03-27 2018-08-22 CD47 binding agents

Country Status (11)

Country Link
US (2) US12421310B2 (https=)
EP (1) EP3774886A1 (https=)
JP (1) JP7458569B2 (https=)
KR (2) KR20260036010A (https=)
CN (1) CN111936515B (https=)
AU (2) AU2019246401B2 (https=)
CA (1) CA3093777A1 (https=)
GB (2) GB201804860D0 (https=)
IL (1) IL277343B1 (https=)
SG (1) SG11202008965SA (https=)
WO (1) WO2019185717A1 (https=)

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CN111212852A (zh) 2017-08-18 2020-05-29 超人肆有限公司 结合剂
GB201804860D0 (en) 2018-03-27 2018-05-09 Ultrahuman Two Ltd CD47 Binding agents
KR20240137107A (ko) 2019-07-16 2024-09-19 길리애드 사이언시즈, 인코포레이티드 Hiv 백신, 및 이의 제조 및 사용 방법
ES2973832T3 (es) 2019-10-18 2024-06-24 Forty Seven Inc Terapias combinadas para el tratamiento de síndromes mielodisplásicos y leucemia mieloide aguda
JP2022552748A (ja) 2019-10-31 2022-12-19 フォーティ セブン, インコーポレイテッド 抗cd47及び抗cd20による血液癌の治療
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TWI890283B (zh) 2020-02-14 2025-07-11 美商基利科學股份有限公司 結合ccr8之抗體及融合蛋白及其用途
CN115916963A (zh) 2020-03-27 2023-04-04 门德斯有限公司 白血病来源的经修饰细胞用于增强过继性细胞治疗的效力的离体用途
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TWI876305B (zh) 2022-04-05 2025-03-11 美商基利科學股份有限公司 用於治療結腸直腸癌之組合療法
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GB201804860D0 (en) 2018-03-27 2018-05-09 Ultrahuman Two Ltd CD47 Binding agents

Also Published As

Publication number Publication date
US12421310B2 (en) 2025-09-23
KR20260036010A (ko) 2026-03-13
IL277343B1 (en) 2026-04-01
GB201813693D0 (en) 2018-10-03
JP2021519100A (ja) 2021-08-10
US20210179711A1 (en) 2021-06-17
KR102929571B1 (ko) 2026-02-23
AU2019246401A1 (en) 2020-11-05
JP7458569B2 (ja) 2024-04-01
AU2019246401B2 (en) 2025-11-06
WO2019185717A1 (en) 2019-10-03
AU2026200633A1 (en) 2026-02-19
CN111936515B (zh) 2024-04-19
US20260015420A1 (en) 2026-01-15
CN111936515A (zh) 2020-11-13
IL277343A (en) 2020-10-29
SG11202008965SA (en) 2020-10-29
CA3093777A1 (en) 2019-10-03
KR20200136424A (ko) 2020-12-07
EP3774886A1 (en) 2021-02-17

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