GB201710620D0 - Targeted protein degradation - Google Patents

Targeted protein degradation

Info

Publication number
GB201710620D0
GB201710620D0 GBGB1710620.4A GB201710620A GB201710620D0 GB 201710620 D0 GB201710620 D0 GB 201710620D0 GB 201710620 A GB201710620 A GB 201710620A GB 201710620 D0 GB201710620 D0 GB 201710620D0
Authority
GB
United Kingdom
Prior art keywords
protein degradation
targeted protein
targeted
degradation
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1710620.4A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Intellectual Property Development Ltd
Original Assignee
GlaxoSmithKline Intellectual Property Development Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline Intellectual Property Development Ltd filed Critical GlaxoSmithKline Intellectual Property Development Ltd
Priority to GBGB1710620.4A priority Critical patent/GB201710620D0/en
Publication of GB201710620D0 publication Critical patent/GB201710620D0/en
Priority to GB1810814.2A priority patent/GB2568987A/en
Priority to US16/024,999 priority patent/US10683360B2/en
Priority to CN201880057133.9A priority patent/CN110997710A/zh
Priority to JP2019572373A priority patent/JP7369039B2/ja
Priority to PCT/EP2018/067741 priority patent/WO2019007869A1/en
Priority to BR112019028024-3A priority patent/BR112019028024A2/pt
Priority to EP18735571.4A priority patent/EP3649149A1/en
Priority to CA3068365A priority patent/CA3068365A1/en
Priority to US16/879,896 priority patent/US11427643B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
    • A61K40/4215—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
GBGB1710620.4A 2017-07-03 2017-07-03 Targeted protein degradation Ceased GB201710620D0 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
GBGB1710620.4A GB201710620D0 (en) 2017-07-03 2017-07-03 Targeted protein degradation
CA3068365A CA3068365A1 (en) 2017-07-03 2018-07-02 Targeted protein degradation
JP2019572373A JP7369039B2 (ja) 2017-07-03 2018-07-02 標的化タンパク質分解
US16/024,999 US10683360B2 (en) 2017-07-03 2018-07-02 Targeted protein degradation
CN201880057133.9A CN110997710A (zh) 2017-07-03 2018-07-02 靶向的蛋白降解
GB1810814.2A GB2568987A (en) 2017-07-03 2018-07-02 Targeted protein degradation
PCT/EP2018/067741 WO2019007869A1 (en) 2017-07-03 2018-07-02 TARGETED DEGRADATION OF PROTEINS
BR112019028024-3A BR112019028024A2 (pt) 2017-07-03 2018-07-02 método para controlar o nível de uma sequência de polipeptídeos, receptor de antígeno quimérico, proteína de fusão, polinucleotídeo isolado, vetor de expressão, célula, composição farmacêutica, e, método para engenheirar uma célula imunomodulatória.
EP18735571.4A EP3649149A1 (en) 2017-07-03 2018-07-02 Targeted protein degradation
US16/879,896 US11427643B2 (en) 2017-07-03 2020-05-21 Targeted protein degradation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1710620.4A GB201710620D0 (en) 2017-07-03 2017-07-03 Targeted protein degradation

Publications (1)

Publication Number Publication Date
GB201710620D0 true GB201710620D0 (en) 2017-08-16

Family

ID=59592357

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB1710620.4A Ceased GB201710620D0 (en) 2017-07-03 2017-07-03 Targeted protein degradation
GB1810814.2A Withdrawn GB2568987A (en) 2017-07-03 2018-07-02 Targeted protein degradation

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1810814.2A Withdrawn GB2568987A (en) 2017-07-03 2018-07-02 Targeted protein degradation

Country Status (8)

Country Link
US (2) US10683360B2 (https=)
EP (1) EP3649149A1 (https=)
JP (1) JP7369039B2 (https=)
CN (1) CN110997710A (https=)
BR (1) BR112019028024A2 (https=)
CA (1) CA3068365A1 (https=)
GB (2) GB201710620D0 (https=)
WO (1) WO2019007869A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN111107874A (zh) * 2017-09-14 2020-05-05 葛兰素史密斯克莱知识产权发展有限公司 用于癌症的组合治疗

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WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11446398B2 (en) 2016-04-11 2022-09-20 Obsidian Therapeutics, Inc. Regulated biocircuit systems
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
WO2018085208A1 (en) 2016-11-02 2018-05-11 The Research Foundation For The State University Of New York Methods of inhibiting viruses using compositions targeting tsg101-ubiquitin interaction
AU2018351050B2 (en) * 2017-10-18 2025-09-18 Novartis Ag Compositions and methods for selective protein degradation
US12049482B2 (en) * 2017-10-31 2024-07-30 The Brigham And Women's Hospital, Inc. Molecular switch-mediated control of engineered cells
KR102439221B1 (ko) 2017-12-14 2022-09-01 프로디자인 소닉스, 인크. 음향 트랜스듀서 구동기 및 제어기
JP2022517566A (ja) * 2019-01-07 2022-03-09 ユニバーシティ オブ ワシントン タンパク質分解の調整可能な制御のためのタンパク質スイッチの新規設計
WO2020146254A1 (en) * 2019-01-07 2020-07-16 The Regents Of The University Of California Caged-degron-based molecular feedback circuits and methods of using the same
CN111825769B (zh) * 2019-04-16 2022-03-25 上海科技大学 一种泛素化缺失的嵌合抗原受体及其用途
EP3959320A1 (en) * 2019-04-24 2022-03-02 Novartis AG Compositions and methods for selective protein degradation
JP7523541B2 (ja) * 2019-11-27 2024-07-26 ワンジーン バイオテクノロジー インコーポレイテッド 生体内における持続時間が延長された多機能性多重特異性マルチマー生体分子重合体
WO2021162394A1 (ko) * 2020-02-14 2021-08-19 충북대학교 산학협력단 B세포 성숙화 항원을 표적으로 하는 키메라 항원 수용체 및 이의 용도
CN114057890A (zh) * 2020-07-31 2022-02-18 南京北恒生物科技有限公司 新型共刺激结构域及其用途
CN116368152A (zh) * 2020-09-13 2023-06-30 山东博安生物技术股份有限公司 通过受体tac技术的膜结合蛋白的下调
CN112266404A (zh) * 2020-10-28 2021-01-26 北京大学深圳研究生院 选择性修饰靶标蛋白的基团转移方法及其应用
CN112940096A (zh) * 2021-01-29 2021-06-11 西安交通大学 一种膀胱癌血清多肽标志物及其应用
WO2022161502A1 (zh) * 2021-02-01 2022-08-04 羿尊生物医药（浙江）有限公司 一种靶向蛋白降解系统及其应用
CN112980882A (zh) * 2021-03-15 2021-06-18 上海科技大学 Crbn基因在构建GSPT1敏感模型中的用途
CA3223636A1 (en) * 2021-08-06 2023-02-09 Christopher Walton CARROLL Compositions and methods for selective degradation of engineered proteins
NL2031325B1 (en) 2022-03-18 2023-09-29 Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis Novel zinc finger degron sequences
KR20250120279A (ko) 2022-12-01 2025-08-08 에테하 취리히 변형된 아미노산 데그론(maad)을 식별하기 위한 방법
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CN103265635A (zh) * 2013-04-28 2013-08-28 中山大学附属第一医院 一种通用的靶向蛋白嵌合型分子化合物的构建方法
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JP7100028B2 (ja) * 2016-10-20 2022-07-12 セルジーン コーポレイション セレブロン系のヘテロ二量体化可能なキメラ抗原受容体

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111107874A (zh) * 2017-09-14 2020-05-05 葛兰素史密斯克莱知识产权发展有限公司 用于癌症的组合治疗

Also Published As

Publication number Publication date
US20190002578A1 (en) 2019-01-03
CA3068365A1 (en) 2019-01-10
US10683360B2 (en) 2020-06-16
WO2019007869A1 (en) 2019-01-10
GB2568987A (en) 2019-06-05
JP2020529970A (ja) 2020-10-15
JP7369039B2 (ja) 2023-10-25
GB201810814D0 (en) 2018-08-15
US11427643B2 (en) 2022-08-30
US20200283538A1 (en) 2020-09-10
EP3649149A1 (en) 2020-05-13
CN110997710A (zh) 2020-04-10
BR112019028024A2 (pt) 2020-07-07

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