GB2009927A - Test method for detection of malignant tumours - Google Patents
Test method for detection of malignant tumoursInfo
- Publication number
- GB2009927A GB2009927A GB7847795A GB7847795A GB2009927A GB 2009927 A GB2009927 A GB 2009927A GB 7847795 A GB7847795 A GB 7847795A GB 7847795 A GB7847795 A GB 7847795A GB 2009927 A GB2009927 A GB 2009927A
- Authority
- GB
- United Kingdom
- Prior art keywords
- mif
- lymphocytes
- contacted
- intermediate layer
- migration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Physiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
An in vitro testing method for the diagnosis of malignant tumours preferably human tumours, by determining the mobility variation of cellular blood components contacted with a migration inhibition factor (MIF), the MIF being secreted from lymphocytes being sensitized against tumour tissue, comprises subjecting, as said cellular blood components, the lymphocytes contained in a leucocyte suspension to be examined to a migration inhibition test. The lymphocytes are contacted with an antigen capable of stimulating them to produce MIF. The leucocyte migration is inhibited and fixed after a predetermined period of time. The leucocytes migrate in a capillary intermediate layer having a thickness of from 1 to 20 microns and being at least partially filled with liquid. Said intermediate layer is formed between a glass surface and an agar layer. The invention further refers to the construction and preparation of a testing plate or dish comprising these layers.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2755363A DE2755363C3 (en) | 1977-12-12 | 1977-12-12 | Test method for diagnosing malignancies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2009927A true GB2009927A (en) | 1979-06-20 |
| GB2009927B GB2009927B (en) | 1982-10-06 |
Family
ID=6025947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7847795A Expired GB2009927B (en) | 1977-12-12 | 1978-12-08 | Vitro testing method for the diagnosis of malignant tumours |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPS54100176A (en) |
| AR (1) | AR220356A1 (en) |
| AT (1) | AT360178B (en) |
| AU (1) | AU4234978A (en) |
| BE (1) | BE872651A (en) |
| CA (1) | CA1129319A (en) |
| CH (1) | CH646793A5 (en) |
| DD (1) | DD139903A5 (en) |
| DE (1) | DE2755363C3 (en) |
| DK (1) | DK532678A (en) |
| ES (2) | ES475905A1 (en) |
| FI (1) | FI783782A (en) |
| FR (1) | FR2411412A1 (en) |
| GB (1) | GB2009927B (en) |
| GR (1) | GR66576B (en) |
| IL (1) | IL56152A0 (en) |
| IT (1) | IT1160323B (en) |
| LU (1) | LU80609A1 (en) |
| NL (1) | NL7811903A (en) |
| NO (1) | NO784096L (en) |
| PL (1) | PL112675B1 (en) |
| PT (1) | PT68891A (en) |
| RO (1) | RO75333A (en) |
| SE (1) | SE432157B (en) |
| ZA (1) | ZA786908B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0067646A1 (en) * | 1981-06-09 | 1982-12-22 | Ortho Diagnostic Systems Inc. | In vitro method and test kit for determining cellular immunocompetence |
| EP0162812A2 (en) * | 1984-05-24 | 1985-11-27 | Ciba-Geigy Ag | Lymphokine in the pure state, monoclonal antibodies, hybridoma cell lines, processes and applications |
-
1977
- 1977-12-12 DE DE2755363A patent/DE2755363C3/en not_active Expired
-
1978
- 1978-11-29 DK DK532678A patent/DK532678A/en unknown
- 1978-11-29 GR GR57767A patent/GR66576B/el unknown
- 1978-11-29 SE SE7812313A patent/SE432157B/en unknown
- 1978-12-01 CH CH1232978A patent/CH646793A5/en not_active IP Right Cessation
- 1978-12-04 LU LU80609A patent/LU80609A1/en unknown
- 1978-12-06 AT AT872478A patent/AT360178B/en active
- 1978-12-06 NO NO784096A patent/NO784096L/en unknown
- 1978-12-06 NL NL7811903A patent/NL7811903A/en not_active Application Discontinuation
- 1978-12-07 IL IL56152A patent/IL56152A0/en unknown
- 1978-12-08 FI FI783782A patent/FI783782A/en unknown
- 1978-12-08 DD DD78209631A patent/DD139903A5/en unknown
- 1978-12-08 AU AU42349/78A patent/AU4234978A/en active Pending
- 1978-12-08 GB GB7847795A patent/GB2009927B/en not_active Expired
- 1978-12-09 RO RO7895854A patent/RO75333A/en unknown
- 1978-12-11 ES ES475905A patent/ES475905A1/en not_active Expired
- 1978-12-11 FR FR7834749A patent/FR2411412A1/en active Granted
- 1978-12-11 PT PT68891A patent/PT68891A/en unknown
- 1978-12-11 BE BE2057477A patent/BE872651A/en not_active IP Right Cessation
- 1978-12-11 ZA ZA00786908A patent/ZA786908B/en unknown
- 1978-12-12 JP JP15459078A patent/JPS54100176A/en active Pending
- 1978-12-12 AR AR274770A patent/AR220356A1/en active
- 1978-12-12 IT IT30722/78A patent/IT1160323B/en active
- 1978-12-12 PL PL1978211672A patent/PL112675B1/en unknown
- 1978-12-12 CA CA317,809A patent/CA1129319A/en not_active Expired
-
1979
- 1979-05-25 ES ES1979243564U patent/ES243564Y/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0067646A1 (en) * | 1981-06-09 | 1982-12-22 | Ortho Diagnostic Systems Inc. | In vitro method and test kit for determining cellular immunocompetence |
| EP0162812A2 (en) * | 1984-05-24 | 1985-11-27 | Ciba-Geigy Ag | Lymphokine in the pure state, monoclonal antibodies, hybridoma cell lines, processes and applications |
| EP0162812A3 (en) * | 1984-05-24 | 1988-04-20 | Ciba-Geigy Ag | Lymphokine in the pure state, monoclonal antibodies, hybridoma cell lines, processes and applications |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7811903A (en) | 1979-06-14 |
| FI783782A (en) | 1979-06-13 |
| PT68891A (en) | 1979-07-24 |
| DE2755363A1 (en) | 1979-06-13 |
| SE7812313L (en) | 1979-06-13 |
| IL56152A0 (en) | 1979-03-12 |
| ATA872478A (en) | 1980-05-15 |
| ES243564Y (en) | 1980-12-16 |
| AT360178B (en) | 1980-12-29 |
| NO784096L (en) | 1979-06-13 |
| LU80609A1 (en) | 1979-05-16 |
| JPS54100176A (en) | 1979-08-07 |
| BE872651A (en) | 1979-03-30 |
| DK532678A (en) | 1979-06-13 |
| FR2411412A1 (en) | 1979-07-06 |
| IT7830722A0 (en) | 1978-12-12 |
| PL211672A1 (en) | 1979-09-10 |
| AU4234978A (en) | 1979-06-21 |
| ES475905A1 (en) | 1979-10-16 |
| IT1160323B (en) | 1987-03-11 |
| AR220356A1 (en) | 1980-10-31 |
| DE2755363C3 (en) | 1983-12-01 |
| PL112675B1 (en) | 1980-10-31 |
| SE432157B (en) | 1984-03-19 |
| DE2755363B2 (en) | 1979-12-20 |
| GR66576B (en) | 1981-03-27 |
| DD139903A5 (en) | 1980-01-23 |
| GB2009927B (en) | 1982-10-06 |
| ZA786908B (en) | 1979-12-27 |
| FR2411412B3 (en) | 1981-03-27 |
| CH646793A5 (en) | 1984-12-14 |
| CA1129319A (en) | 1982-08-10 |
| RO75333A (en) | 1980-11-30 |
| ES243564U (en) | 1980-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |