ES475905A1 - Test method for detection of malignant tumours - Google Patents
Test method for detection of malignant tumoursInfo
- Publication number
- ES475905A1 ES475905A1 ES475905A ES475905A ES475905A1 ES 475905 A1 ES475905 A1 ES 475905A1 ES 475905 A ES475905 A ES 475905A ES 475905 A ES475905 A ES 475905A ES 475905 A1 ES475905 A1 ES 475905A1
- Authority
- ES
- Spain
- Prior art keywords
- mif
- lymphocytes
- contacted
- intermediate layer
- migration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Physiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
An in vitro testing method for the diagnosis of malignant tumours preferably human tumours, by determining the mobility variation of cellular blood components contacted with a migration inhibition factor (MIF), the MIF being secreted from lymphocytes being sensitized against tumour tissue, comprises subjecting, as said cellular blood components, the lymphocytes contained in a leucocyte suspension to be examined to a migration inhibition test. The lymphocytes are contacted with an antigen capable of stimulating them to produce MIF. The leucocyte migration is inhibited and fixed after a predetermined period of time. The leucocytes migrate in a capillary intermediate layer having a thickness of from 1 to 20 microns and being at least partially filled with liquid. Said intermediate layer is formed between a glass surface and an agar layer. The invention further refers to the construction and preparation of a testing plate or dish comprising these layers.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2755363A DE2755363C3 (en) | 1977-12-12 | 1977-12-12 | Test method for diagnosing malignancies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES475905A1 true ES475905A1 (en) | 1979-10-16 |
Family
ID=6025947
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES475905A Expired ES475905A1 (en) | 1977-12-12 | 1978-12-11 | Test method for detection of malignant tumours |
| ES1979243564U Expired ES243564Y (en) | 1977-12-12 | 1979-05-25 | AN IN VITRO TEST PLATE FOR DIAGNOSIS OF MA-LLIGNOS TUMORS. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES1979243564U Expired ES243564Y (en) | 1977-12-12 | 1979-05-25 | AN IN VITRO TEST PLATE FOR DIAGNOSIS OF MA-LLIGNOS TUMORS. |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPS54100176A (en) |
| AR (1) | AR220356A1 (en) |
| AT (1) | AT360178B (en) |
| AU (1) | AU4234978A (en) |
| BE (1) | BE872651A (en) |
| CA (1) | CA1129319A (en) |
| CH (1) | CH646793A5 (en) |
| DD (1) | DD139903A5 (en) |
| DE (1) | DE2755363C3 (en) |
| DK (1) | DK532678A (en) |
| ES (2) | ES475905A1 (en) |
| FI (1) | FI783782A (en) |
| FR (1) | FR2411412A1 (en) |
| GB (1) | GB2009927B (en) |
| GR (1) | GR66576B (en) |
| IL (1) | IL56152A0 (en) |
| IT (1) | IT1160323B (en) |
| LU (1) | LU80609A1 (en) |
| NL (1) | NL7811903A (en) |
| NO (1) | NO784096L (en) |
| PL (1) | PL112675B1 (en) |
| PT (1) | PT68891A (en) |
| RO (1) | RO75333A (en) |
| SE (1) | SE432157B (en) |
| ZA (1) | ZA786908B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4436824A (en) * | 1981-06-09 | 1984-03-13 | Ortho Diagnostic Systems, Inc. | Leukocyte migration through antigen containing agaroses for immunocompetence testing |
| JPH0672158B2 (en) * | 1984-05-24 | 1994-09-14 | チバ−ガイギ− アクチエンゲゼルシヤフト | Purified human macrophage migration inhibitory factor |
-
1977
- 1977-12-12 DE DE2755363A patent/DE2755363C3/en not_active Expired
-
1978
- 1978-11-29 SE SE7812313A patent/SE432157B/en unknown
- 1978-11-29 GR GR57767A patent/GR66576B/el unknown
- 1978-11-29 DK DK532678A patent/DK532678A/en unknown
- 1978-12-01 CH CH1232978A patent/CH646793A5/en not_active IP Right Cessation
- 1978-12-04 LU LU80609A patent/LU80609A1/en unknown
- 1978-12-06 AT AT872478A patent/AT360178B/en active
- 1978-12-06 NL NL7811903A patent/NL7811903A/en not_active Application Discontinuation
- 1978-12-06 NO NO784096A patent/NO784096L/en unknown
- 1978-12-07 IL IL56152A patent/IL56152A0/en unknown
- 1978-12-08 FI FI783782A patent/FI783782A/en unknown
- 1978-12-08 AU AU42349/78A patent/AU4234978A/en active Pending
- 1978-12-08 DD DD78209631A patent/DD139903A5/en unknown
- 1978-12-08 GB GB7847795A patent/GB2009927B/en not_active Expired
- 1978-12-09 RO RO7895854A patent/RO75333A/en unknown
- 1978-12-11 ZA ZA00786908A patent/ZA786908B/en unknown
- 1978-12-11 PT PT68891A patent/PT68891A/en unknown
- 1978-12-11 FR FR7834749A patent/FR2411412A1/en active Granted
- 1978-12-11 ES ES475905A patent/ES475905A1/en not_active Expired
- 1978-12-11 BE BE2057477A patent/BE872651A/en not_active IP Right Cessation
- 1978-12-12 JP JP15459078A patent/JPS54100176A/en active Pending
- 1978-12-12 AR AR274770A patent/AR220356A1/en active
- 1978-12-12 PL PL1978211672A patent/PL112675B1/en unknown
- 1978-12-12 IT IT30722/78A patent/IT1160323B/en active
- 1978-12-12 CA CA317,809A patent/CA1129319A/en not_active Expired
-
1979
- 1979-05-25 ES ES1979243564U patent/ES243564Y/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| RO75333A (en) | 1980-11-30 |
| ATA872478A (en) | 1980-05-15 |
| FR2411412B3 (en) | 1981-03-27 |
| LU80609A1 (en) | 1979-05-16 |
| CH646793A5 (en) | 1984-12-14 |
| DE2755363A1 (en) | 1979-06-13 |
| PL211672A1 (en) | 1979-09-10 |
| JPS54100176A (en) | 1979-08-07 |
| DD139903A5 (en) | 1980-01-23 |
| DK532678A (en) | 1979-06-13 |
| NO784096L (en) | 1979-06-13 |
| DE2755363C3 (en) | 1983-12-01 |
| FI783782A (en) | 1979-06-13 |
| ES243564U (en) | 1980-06-01 |
| ZA786908B (en) | 1979-12-27 |
| BE872651A (en) | 1979-03-30 |
| FR2411412A1 (en) | 1979-07-06 |
| ES243564Y (en) | 1980-12-16 |
| GR66576B (en) | 1981-03-27 |
| SE432157B (en) | 1984-03-19 |
| GB2009927A (en) | 1979-06-20 |
| IT1160323B (en) | 1987-03-11 |
| AR220356A1 (en) | 1980-10-31 |
| CA1129319A (en) | 1982-08-10 |
| IT7830722A0 (en) | 1978-12-12 |
| DE2755363B2 (en) | 1979-12-20 |
| GB2009927B (en) | 1982-10-06 |
| PT68891A (en) | 1979-07-24 |
| AU4234978A (en) | 1979-06-21 |
| PL112675B1 (en) | 1980-10-31 |
| AT360178B (en) | 1980-12-29 |
| IL56152A0 (en) | 1979-03-12 |
| NL7811903A (en) | 1979-06-14 |
| SE7812313L (en) | 1979-06-13 |
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