GB2005659A - Substituted alpha -Halomethyl Phenylalanines - Google Patents

Substituted alpha -Halomethyl Phenylalanines

Info

Publication number
GB2005659A
GB2005659A GB7827966A GB7827966A GB2005659A GB 2005659 A GB2005659 A GB 2005659A GB 7827966 A GB7827966 A GB 7827966A GB 7827966 A GB7827966 A GB 7827966A GB 2005659 A GB2005659 A GB 2005659A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
carbon atoms
carbonyl
alkyl
phenylalanines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7827966A
Other versions
GB2005659B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merrell Toraude et Cie
Original Assignee
Merrell Toraude et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Toraude et Cie filed Critical Merrell Toraude et Cie
Publication of GB2005659A publication Critical patent/GB2005659A/en
Application granted granted Critical
Publication of GB2005659B publication Critical patent/GB2005659B/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06191Dipeptides containing heteroatoms different from O, S, or N
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Novel pharmaceutically useful compounds of the formula <IMAGE> and pharmaceutically acceptable salts and individual optical isomers thereof, wherein Y is -CH2F, -CHF2, -CH2Cl or -CHCl2; R1 is hydrogen, (C1-4alkyl)carbonyl, (C1-4alkoxy)carbonyl or -CO-CHNH2-R27 wherein R27 is hydrogen, alkyl of 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R is hydroxy, alkoxy of 1 to 8 carbon atoms, -NR7R8 wherein R7 and R8 are the same or different and are each hydrogen or alkyl of 1 to 4 carbon atoms or -NH-CHR9-COOH wherein R9 is hydrogen, alkyl of 1 to 4 carbon atoms, benzyl or p- hydroxybenzyl; and R2, R3, R4, R5 and R6 are various combinations of hydrogen, methyl, ethyl, tert-butyl, halogen, trifluoromethyl and OR10 wherein R10 is hydrogen, alkyl of 1 to 8 carbon atoms, (C1-6alkyl)carbonyl, benzoyl or phenyl (C1-6alkyl)-carbonyl or R3 and R4 together are methylenedioxy.
GB7827966A 1977-07-11 1978-06-27 Halomethyl amino acids Expired GB2005659B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81424377A 1977-07-11 1977-07-11

Publications (2)

Publication Number Publication Date
GB2005659A true GB2005659A (en) 1979-04-25
GB2005659B GB2005659B (en) 1982-02-17

Family

ID=25214519

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7827966A Expired GB2005659B (en) 1977-07-11 1978-06-27 Halomethyl amino acids

Country Status (16)

Country Link
JP (1) JPS5484544A (en)
AU (1) AU525684B2 (en)
BE (1) BE868881A (en)
CH (1) CH636846A5 (en)
DE (1) DE2828738A1 (en)
DK (1) DK309378A (en)
ES (3) ES471595A1 (en)
FR (1) FR2397391A1 (en)
GB (1) GB2005659B (en)
IE (1) IE46932B1 (en)
IL (1) IL54913A0 (en)
IT (1) IT1105534B (en)
NL (1) NL7807454A (en)
NZ (1) NZ187538A (en)
SE (1) SE7807690L (en)
ZA (1) ZA783273B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007600A1 (en) * 1978-07-24 1980-02-06 Merck & Co. Inc. Alpha-difluoromethyl amino acids and pharmaceutical composition containing the same
EP0040150A1 (en) * 1980-05-09 1981-11-18 Merrell Toraude Et Compagnie Fluoromethylated tyrosine methyl ester
JPS5777657A (en) * 1980-08-23 1982-05-15 Merrell Toraude & Co Manufacture of aminonitrile derivative
CN113302176A (en) * 2018-12-06 2021-08-24 先达生物科技公司 Decarboxylase inhibitors for the treatment of parkinson's disease

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59481A0 (en) * 1977-07-11 1980-05-30 Merrell Toraude & Co -halomethyl amino acids
FR2450247A1 (en) * 1979-02-28 1980-09-26 Tamsir Ndike Wade Alpha-amino-beta,beta-di:fluoro carboxylic acid ester(s) - prepd. by reaction of hydrofluoric acid with 2-substd. 3-carboxy-ester-1-azirine have potential use as antibacterials and CNS stimulants
IE49522B1 (en) * 1979-04-26 1985-10-16 Merrell Toraude & Co Alpha-halomethylaminoacids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3046300A (en) * 1960-10-21 1962-07-24 Merck & Co Inc alpha-trifluoromethyloxyphenylalanines
NZ187377A (en) * 1977-06-01 1981-05-15 Merck & Co Inc A-amino-a-substituted alkyl-a-fluoromethylacetic acids
IE47542B1 (en) * 1977-06-01 1984-04-18 Merck & Co Inc Di-and tri-fluoromethyl amino acids and amines,compositions and processes for preparing said compounds

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007600A1 (en) * 1978-07-24 1980-02-06 Merck & Co. Inc. Alpha-difluoromethyl amino acids and pharmaceutical composition containing the same
EP0040150A1 (en) * 1980-05-09 1981-11-18 Merrell Toraude Et Compagnie Fluoromethylated tyrosine methyl ester
JPS5777657A (en) * 1980-08-23 1982-05-15 Merrell Toraude & Co Manufacture of aminonitrile derivative
JPH0330587B2 (en) * 1980-08-23 1991-04-30
CN113302176A (en) * 2018-12-06 2021-08-24 先达生物科技公司 Decarboxylase inhibitors for the treatment of parkinson's disease
EP3891122A4 (en) * 2018-12-06 2022-10-05 Senda Biosciences, Inc. Decarboxylase inhibitors for treating parkinson's disease

Also Published As

Publication number Publication date
JPS5484544A (en) 1979-07-05
ES478517A1 (en) 1979-07-16
DK309378A (en) 1979-01-12
FR2397391A1 (en) 1979-02-09
ZA783273B (en) 1979-06-27
IT1105534B (en) 1985-11-04
GB2005659B (en) 1982-02-17
AU3731278A (en) 1980-01-03
SE7807690L (en) 1979-01-12
NL7807454A (en) 1979-01-15
ES478516A1 (en) 1979-07-16
DE2828738A1 (en) 1979-02-01
FR2397391B1 (en) 1981-02-20
JPS6326101B2 (en) 1988-05-27
CH636846A5 (en) 1983-06-30
BE868881A (en) 1978-11-03
ES471595A1 (en) 1979-10-01
IE781167L (en) 1979-01-11
IE46932B1 (en) 1983-11-02
NZ187538A (en) 1982-08-17
IT7850230A0 (en) 1978-07-10
AU525684B2 (en) 1982-11-25
IL54913A0 (en) 1978-08-31

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19940627