IE47542B1 - Di-and tri-fluoromethyl amino acids and amines,compositions and processes for preparing said compounds - Google Patents
Di-and tri-fluoromethyl amino acids and amines,compositions and processes for preparing said compoundsInfo
- Publication number
- IE47542B1 IE47542B1 IE1077/78A IE107778A IE47542B1 IE 47542 B1 IE47542 B1 IE 47542B1 IE 1077/78 A IE1077/78 A IE 1077/78A IE 107778 A IE107778 A IE 107778A IE 47542 B1 IE47542 B1 IE 47542B1
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- IE
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- compounds
- difluoromethyl
- compound
- formula
- veratryl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/48—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation involving decarboxylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
alpha -Difluoromethyl-3,4-di- OR-phenylalanines and its esters, and (1-difluoromethyl)- and 1-(trifluoromethyl)-2-(3,4-di-OR- phenyl) ethylamines, wherein R is hydrogen or a C2-C6 alkanoyl, have been prepared. Homoveratric acid is transformed into veratryl-difluoromethyl- ketone or veratryl- trifluoro- methyl- ketone, this reacts with methoxyamine, and the obtained O-methyl-oxime is reduced to the amine. The 3- and 4-methoxygroups are hydrolysed into hydroxy-groups. Reaction of veratryl- difluoromethylketone with ammonium-carbonate and sodium cyanide yields alpha -difluoromethyl-5-(3 min , 4 min -dimethoxybenzyl)-2,4-imidazolidine-dione, hydrolysis results in alpha -difluoromethyl-3- hydroxytyrosine. The compounds have Dopa-decarboxylase inhibiting activity and some of them are antihypertensive agents.
Description
The present invention is concerned with certain difluoromethylphenylalanines and difluoroor trifluoromethyi phenylethylamines.
a-Methyl-3,4-dihydroxyphenylalanine, particularly its L-isomer, is a known antihypertensive agent. (U. S. 2,868,818; U.S. 3,344,023).
Novel α-difluoromethyl-3,4-di-OR-phenylalanines and α-difluoromethyl- or a-trifluoromethyl -3,4-di-OR-ethylamines have been discovered. These compounds have biological activity including decarboxylase inhibition.
The present invention provides compounds having the formula
CHF,
CF, r2o
NH,
R,0-\x* 1®2
II wherein
R is H or COOR. wherein R, is H or C. -C., alkyl and
R2 is H or C2-Cg alkanoyl and the pharmaceutically acceptable salts thereof.
The pharmaceutically acceptable salts of the formula I-II compounds generally are acid addition salts of suitable organic or inorganic acids. Preferred salts are the hydrohalides such as the hydrobromides, the hydrochlorides, the hydrogen iodides. Most preferred salts are the hydrochlorides.
The compounds of formula I-II have a chiral center and may occur in optically active forms, i.e., as optical isomers. These isomers are conventionally designated as D and L, d and 1, + and -, (S) and (R) or by a combination of these symbols. Where the compound name or formula does not specify the isomer form, all forms are included, i.e., the individual isomers, mixtures thereof and racemates.
47S42 of suitable alkyl groups lA are octadecyl, 2-ethyl hexyl, lauryl, undecyl, methyl,isopropyl, hexyl, and the like. Preferred R^ groups are H and Cj-Cg alkyl. Most preferred R^ groups are H and ethyl.
R2 includes H and C2-Cg alkanoyl groups Examples of suitable alkanoyl groups are acetyl, octanoyl, pivaloyl, 2-methylpropanoyl, heptanoyl, butanoyl and the like. The most preferred R2 substituent is hydrogen.
A preferred compound is the trifluoromethyl compound having the formula
The R-isomer of III is more preferred.
A preferred class of compounds of the present invention is that having the formula
OR,
Especially preferred are formula IV compounds where R^ is hydrogen or C^-Cg alkyl, preferably ethyl.
The S-isomer form of the formula IV compound is also more preferred.
47543
Another preferred compound of the present invention is that having the formula
The R-isomer form of the formula V compound is also more preferred.
The compounds of the present invention have 3,4-dihydroxyphenylalanine (DOPA) decarboxylase inhibiting activity. This activity was determined by conventional in-vitro assay procedures. This biological activity permits the present compounds to be used as diagnostic tools to determine the presence and importance of the corresponding decarboxylase in relation to diseases or to functioning of biological systems. Also the present compounds may be used in combination with DOPA to improve DOPA's effectiveness in treating Parkinson's disease.
In addition, some of these compounds, e.g., those of formula IV, the phenylalanines, also have pharmaceutical activity as antihypertensive agents. Thus, these compounds are useful for treating hypertension in humans.
For treating hypertension, the formula IV compounds or their salts may be administered to the hypertensive patient orally, parenterally or via any other suitable administration route. Conventional dosage forms are used such as
47543 tablets, troches, capsules, liquid formulations, e.g. solutions, dispersions, emulsions, elixirs and the like. Conventional compounding ingredients, i.e., diluents, carriers, etc., and con5 ventional preparation procedures are utilized.
The daily dosage of the formula IV compounds may be varied as required. In general, a daily dosage range for the hypertensive patient is about 50 mg to about 5000 mg. A preferred 10 daily dosage range is about 100 mg to about 3500 mg. A more preferred daily dosage range is about 250 to about 1500 mg.
Compounds of the present invention may be prepared by any convenient process.
One such process scheme for preparing the difluoro compounds is illustrated by the following reaction sequence:
CHi»-
ΰ±ΰ (Λ, 6 »Ρ»
NXftWiJWi ΛΜ «4)
Ηβ-^—j, oUt.
μί\ 'W't**'**** *ΰ< i ij ϋ μ (wf^y-L
Ho fie—
Ijiyooi^ (fA /Hw-c-t00'4 \=/ U»t,
I , 47 5 42
Homoveratric acid and its derivatives such as dialkyl amides, esters and thioesters may be transformed into an anionic species with such bases as metalated dialkyl amides (e.g., lithium diisopropylamide), metalated alkyls (e.g., butyl lithium), hydrides (NaH) or metal amides (KNHj). Such anions may be condensed with activated forms of difluoroacetic acid such as its ester, or acid chlorides. Except in the case of homoveratric acid itself, these condensation products require hydrolysis to effect decarboxylation to the difluoromethyl veratryl ketone 1.
A carbon nitrogen bond may be introduced at the ketonic position with the usual amine reagents such as NH3 and hydroxylamine. However, this is most conveniently done by using methoxy amine to form the ketone o-methyl oxime, 2.. This compound may be reduced to the amine 3. using metal catalysts and hydrogen, active metals (e.g., Zn) and most conveniently boranes such as BHj. The cleavage of the phenol ethers can be accomplished with reagents such as BBr^ but is easily effected by heating with hydrohalic acids such as aq. HCl, aq. HBr and the like.
The transformation of the ketone 1 to the α-difluoromethylamino acid 6 is most conveniently accomplished via the hydantoin 5. 5. may be hydrolyzed by acid but most conveniently with HCl. The conversion of 1 to 6 can also be rea30 lized using NH4C1 and NaCN followed by acid hydroly sis.
A process for preparing the trifluoro compounds is illustrated by the following reaction scheme:
(jUUiiwMn'Aji.
^ί77-λ μ ^i-/^S-CVC'Cf:5 Z J^0W«3 &aot*u£ **»
I «wstP J, («« «Cfij pfh.
'CP-€F3
47S42
Homoveratric acid and its derivatives such as dialkyl amides, esters and thio esters may be transformed into an anionic species with such bases as metalated dialkyl amides (e.g., lithium diisopropylamide), metalated alkyls (e.g., butyl lithium), hydrides (NaH) or metal amides (KNH2). Such anions may be condensed with activated forms of trifluoroacetic acid such as its ester or acid chloride. Except in the case of homoveratic acid itself, these condensation products require hydrolysis to effect decarboxylation to the trifluoromethyl veratryl ketone /. A carbon nitrogen bond may be introduced at the ketonic position with the usual amine reagents such as ammonia and hydroxylamine. However, this is most conveniently done by using methoxy amine (NH2OCH3) to form the ketone o-methyl oxime £.
This compound may be reduced to the amine £ using metal catalysts and hydrogen, active metals and most conveniently boranes such as BH3· The cleavage of the phenol ethers can be accomplished with reagents such as BBr3 but is easily effected by heating with hydrohalic acids such as aqueous HCl, aqueous HBr and the like.
The pharmaceutically acceptable salts of the present compounds may be obtained directly from the acid hydrolysis steps described above. Such salts may also be obtained by treatment of the formula I-II free base with an appropriate acid under suitable conditions.
Where the compounds of the present invention are obtained as racemates, they may be separated into the individual enantiomers by conventional resolution techniques. Such tech35 niques commonly involve the formation of a salt of a) a present racemic acid with an optically active base or b) a present racemic amine, with an optically active acid.
The resolution of the racemic is preferably carried out on the Ο,Ο,Ν-triacyl deriva5 tives of the racemic acid. These acyl derivatives are prepared by treatment of the free racemic acid with a suitable acylating agent as illustrated by the following equation:
CHF-
CH2-C—COOH iIh,
HO
HO
// (R-C)20 pyridine
R«substituted or unsubstituted C. -Cc alkyl 1 5
The resolution procedure including hydrolysis of the resolved acylated acids is exemplified in U.S. 3,344,023.
Compounds of the present invention where R2 is lower alkanoyl are prepared by appro15 priately acylating the corresponding compound where and R2 are each H, as illustrated by the following equation:
fie fit)· jfjT iHfx «*1 c, .(UX/i-C—Ci 1-¾ <>iA tieuee)
I un.
C^futfi--'ίc^-C-C -
To prevent acylation of the a-NH2 group the reaction may he carried out in an acid medium, e.g., glacial acetic acid. An example illustra5 ting such an acylation system is in U.S. 3,983,138 Where R^ in formula IV is an alkyl group, the compound is prepared by conventional esterification of the corresponding compound where R^ is H as illustrated by the following equations
WH
XrV fit i -ee^<frA*«A fi&J
The following examples illustrate the preparation of compounds of the present invention. All temperatures are in °C. The melting points were obtained in open capillary and are uncorrected.
EXAMPLE 1
PREPARATION OF a-DIFLUOROMETHYL-2-(3 ' ,4 DIHYDROXYPHENYL)ETHYLAMINE
a. Veratryl difluoromethyl ketone (1)
A 1-liter three-neck flask, fitted with a magnetic stirrer, condenser, nitrogen inlet, and septum was charged with 23 ml of diisopropylamine (176 mmoles) and 50 ml of tetrahydrofuran (THF). The solution was cooled to 0°C followed by addition of 76 ml of 2.1M nbutyl lithium in hexane (159.6 mmoles) over a period of 15 min. The solution was then cooled to -78°C and to it was added 15.68 g of homoveratric acid (80 mmoles) in 80 ml of THF. The addition required 25 min and the temperature was not permitted to exceed -40°C. On completion of the addition, 35 ml of THF were added and the resulting mixture was stirred in an ice bath for 3 hours. It was then recooled to -78°C and
.3 g of ethyl difluoroacetate (83 mmoles) in 90 ml of THF were added. The mixture was then aged at -78'C for 2 hrs, and 1 hr. at 0°c, after which it was worked up by quenching onto 600 ml of 2N HCl, extracting with 3 x 300 ml of ethyl acetate, backwashing with 5% aq. NaHCO3 and saturated NaCl solution. The organic solution was concentrated to give veratryl difluoromethyl ketone (1); this compound forms a crystalline 2,4-dinitrophenyl hydrazone, m.p. 107109ec. Small amounts of this ketone were purified by preparative thin layer chromatography as follows: Α ΙΟΟΟμ silica gel plate was spotted with 175 mg of crude 1 and developed with a
47543
70:30 chloroform:acetone mixture affording about 110 mg of single spot material.
b.) Veratryl difluoromethyl ketone 0methyl oxime (2)_
125 mg of 1 was dissolved in 1.1 ml of pyridine and treated with 125 mg of methoxyamine hydrochloride and the mixture was allowed to remain overnight at room temperature. It was then quenched on water. The aqueous mixture was extracted with ethyl acetate, dried and concentrated to 120 mg of single spot material (70:30 chloroform:acetone, silica plates). This material had an NMR spectrum which was consistent with a syn-anti mixture of the desired oxime £.
c.) R,S-l-Difluoromethyl-2-(3',4'-dimethoxyphenyl)ethylamine hydrochloride (3)
120 mg of £ was charged to a 2-neck 15-ml flask fitted with a septum and condenser and N2 inlet. The material was dissolved in 1 ml of THF, cooled in an ice bath. After 1.5 ml 1M BH^ in THF had been slowly added through the septum using a syringe, the solution was stirred at reflux for 2 hrs. and then at room temperature for 16 hrs. It was then quenched onto 10 ml of methanol. To this was added 1 ml cone. HCl and the solution aged for 2 hrs. and then concentrated to dryness to afford R,S-l-difluoromethyl2-(31,4'-dimethoxyphenyl)ethylamine hydrochloride (3), m.p. 164-167eC (mass spectrum m/e = 231).
d.) R,S-l-Difluoromethyl-2-(3’,4'-dihydroxyphenyl) ethylamine heminaphthalene 1,5-disulfonate (4)_
650 mg of £ was dissolved in 13 ml of cone. HCl and the solution heated under N2 in a sealed tube at 130°C for 30 min. The solution
47543 was concentrated to dryness in vacuo, the residue applied to a 15-ml AG-50X8 (200-400 mesh) Dowex 50 cation exchange resin column H+ form. The column was washed with 250 ml HjO and then eluted with 3N HCl containing 10% methanol. 20 ml fractions were collected and the effluent monitored by a UV detector. Fractions 2-51 were combined and concentrated to give R,S-difluoromethyl-2- (3 1,4'-dihydroxyphenyl)ethylamine (R,Sα-difluoromethyl-2-(3',4'-dihydroxyphenyi)ethylamine heminaphthalene 1,5-disulfonate (£) hydrochloride. 360 mg of this material were dissolved in 3 ml of 2-propanol and 216 mg of naphthalene 1,5-disulfonic acid were added. The solution was concentrated to dryness and the residue redissolved in 2-propanol and reconcentrated. This procedure was repeated three times (to remove HCl). Before the final concentration, the solution was filtered through analytical filter aid (Celite). Concentration followed by trituration with acetonitrile afforded the hemi naphthalene 1,5-disulfonate of £, m.p. 244-247’C Dec.
EXAMPLE 2
R,S-tt-Difluoromethyl-3-Hydroxy-Tyrosine
a.) R, S-a-Difluoromethyl-5-(3',4'-dimethoxybenzyl) -2,4-imidazolidine dione (5)_
To 137 mg of veratryl difluoromethyl ketone charged to a 5-ml flask, there was added 267 mg of ammonium carbonate, 0.6 ml of ethanol and 0.4 ml of H2O. The mixture was stirred at 55’C for 15 min and then 30 mg of sodium cyanide was added. The mixture was heated for 24 hrs
47543 at 55® and then allowed to remain at room temperature for 60 hrs. Then it was acidified to pH 5 with cone. HCl (gas is evolved) and a crystalline precipitate is formed which is washed with H2O (2x1 ml) and air dried affording the hydantoin, 5-difluoromethyl-5-(3', 4'-dimethoxybenzyl)-2,4-imidazolidine dione (5), m.p. 222225°C.
b.) R,S-a-Difluoromethyl-3-Hydroxy10 Tyrosine_
250 mg of the hydantoin 5 was dissolved in 10 ml of oonc. HCl and heated at 130® for 18.5 hrs. The solution was then concentrated to dryness and the residue was applied to a 10-ml column of AG-50X8 (200-400 mesh) cation exchange resin H+ form and eluted with H2O. 20-ml fractions were collected and the effluent was monitored by a LKB UVICORD II UV monitor. The UV absorbing fractions 5-34 gave positive ninhydrin tests and were combined and concentrated in vacuo to dryness to give R,S-a-difluoromethyl-3-hydroxy-tyrosine, m.p. 268-270°C dec.
EXAMPLE 3
Preparation of R,S-l-a-Trifluoromethyl-2-(3’,4’dihydroxyphenyl)ethylamine_
a. Veratryl trifluoromethyi ketone (7)
A 250 ml. flask fitted with stirrer, condenser, nitrogen inlet and septum was charged with 2.76 ml of diisopropylamine and 20 ml of THF. The solution was cooled to 0°C. followed by addition of 19 ml of 2.1M butyl lithium in hexane over a period of 15 minutes. The solution was then cooled to -78°C and to it was added
3.92 g of homoveratric aoid in 50 ml of- THF. The flask was removed from the -78’ bath and immersed in an ice bath for 3 hours. The solution was recooled to -78°C. and to it was added 2.84 g ethyl trifluoroacetate in 20 ml of THF. After stirring at -78° for 0.5 hours, the solution was warmed to 0° and stirred for 1.5 hours at this temperature.
It was then quenched into 100 ml 3N HCI, which was then extracted with 3 x 75 ml of ethyl acetate, backwashed with HjO and 5% aqueous NaHCOg and saturated NaCl solution. The organic layer was dried over Na2SO4 and concentrated to give crude veratryl trifluoromethyl ketone (7). This was purified by thin layer chromatography (80:20 chloroform:acetone, silica gel) and recrystallized from cyclohexane to afford pure 7, m.p. 86-88’C.
b. ) Veratryl trifluoromethyl ketone-0methyl oxime (8)_
530 Mg of 7_ was dissolved in 3 ml of pyridine and treated with 500 mg of methoxyamine hydrochloride and the resulting solution was allowed to remain at room temperature overnight. The pyridine was -concentrated to a small volume and the residue extracted with ethyl acetate and water. Drying and concentration of the organic layer afforded the crude 0-methyl oxime £. Purification was effected by thin layer chromatography (80:20 chloroform:acetone, silic gel) and the lead spot proved to be pure 8.
c. ) R,S-l-trifluoromethyl-2-(3',4'dimethoxyphenyl)ethylamine (9)
200 Mg of 8 was dissolved in 2 ml of THF and charged to a 15 ml 2-neek flask fitted with a septum and condenser. The flask was cooled in an ice bath and 3 ml of IM BH^ in THF was added. The solution was then refluxed for 1.5 hours and then allowed to remain at room temperature overnight. The solution was quenched into 5 ml of methanol and 1 ml of concentrated HCl was added. After aging for 2 hours, it was concentrated, redissolved in 5 ml of concentrated HCl and reconcentrated to 250 mg of crude 9_ hydro10 chloride. The material was dissolved in H2O, basified with 2.5N NaOH and extracted with ethyl acetate. The organic layer was dried and concentrated to give R,S-l-trifluoromethyl-2-(3',
4'-dimethoxyphenyl)ethylamine (9).
(The hemi naphthalene 1,5-disulfonate salt was prepared by treating 40 mg of 9 with 23 mg of naphthalene 1,5-disulfonic acid in 2-propanol and concentrating to dryness. The residue was twice redissolved and reconcentrated and then triturated with acetonitrile to give the crystalline hemi naphthalene disulfonate salt of 2, m.p. 265-268eC.).
d.) R,S-l-trifluoromethyl-2-(31,4'dihydroxyphenyl)ethylamine (10)
730 Mg of 9_ was dissolved in 7 ml concentrated HCl and heated at 130° in a sealed tube for 1.25 hours. The solution was then concentrated to 725 mg of crude hydrochloride of 10. This was dissolved in 20 ml of 2-propanol and treated with 406 mg of naphthalene 1,5-disulfonic acid. The solution was concentrated to dryness and redissolved in 2-propanol. This procedure was repeated twice and finally concentrated to dryness. Trituration of the residue with 30 ml of acetonitrile afforded the hemi naphthalene 1,5-disulfonate of R,s-l-trifluoromethyl-2-(3',4'-dihydroxyphenyl)ethylamine (10), m-P· 287-290°C. dec.
The R,S-l-trifluoromethyl-2-(3',4 dihydroxyphenyl)ethylamine is obtained by conventional neutralization of the disulfonate.
Claims to the invention follow.
Claims (6)
- CLAIMS: wherein wherein 5 R is H or R 1 is H or R 2 is H or pharmaceutically acceptable salts thereof.
- 2. Compounds of Claim 1 wherein R 2 is hydrogen. R 2 are each H.
- 3. Compounds of Claim 1 wherein R^ and
- 4. Compounds of Claim 1 having the CHF, formula CH,-C— COOR, 2 , 1 NH, is H, 5. Compounds of R^ is H or ethyl. Claim 4 wherein R 2 is H. 47543 6. Compounds of Claim 5 wherein R^ 7. Compounds of Claim 6 having the Sisomer configuration. 5 8. Compounds of Claim 1 having the formula ?hf„ R 2 O—^ i \_CH,-C-H NIL· 9. Compounds of Claim 8 wherein R 2 is H. 10 10· Compounds of Claim 9 having the R-isomer configuration. 11. A pharmaceutical composition containing a compound of Claim 1. 12. A process for preparing a com15pound of Claim 1 wherein R^ and Rj are each hydrogen which comprises hydrolyzing (a) a compound having the formula to obtain said Claim 1 compound (I) 47543 where R is -COOH, (b) a compound having the formula to obtain said Claim 1 compound (I) 5 where R is H. or (c) a compound of the formula to obtain said Claim 1 compound. 10 13. Compound of Claim 1 having the formula 14. Compound of Claim 13 having the R-isomer configuration. 15. A process for preparing a compound of the formula given and defined in Claim 1, substantially as herein described with reference to any of the Examples.
- 5. 1
- 6. A compound of the formula given and defined in Claim 1, whenever prepared by a process claimed in a preceding claim.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80238877A | 1977-06-01 | 1977-06-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
IE781077L IE781077L (en) | 1978-12-01 |
IE47542B1 true IE47542B1 (en) | 1984-04-18 |
Family
ID=25183563
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE1077/78A IE47542B1 (en) | 1977-06-01 | 1978-05-30 | Di-and tri-fluoromethyl amino acids and amines,compositions and processes for preparing said compounds |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0000034B1 (en) |
JP (1) | JPS5416437A (en) |
DE (1) | DE2862407D1 (en) |
DK (1) | DK240678A (en) |
IE (1) | IE47542B1 (en) |
IT (1) | IT7849635A0 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA783273B (en) * | 1977-07-11 | 1979-06-27 | Merrell Toraude & Co | A-halomethyl amino acids |
IL59481A0 (en) * | 1977-07-11 | 1980-05-30 | Merrell Toraude & Co | -halomethyl amino acids |
AU3872678A (en) * | 1977-09-01 | 1980-02-14 | Merrell Toraude & Co | Alpha-halomethyl amines |
IE49522B1 (en) * | 1979-04-26 | 1985-10-16 | Merrell Toraude & Co | Alpha-halomethylaminoacids |
NZ194348A (en) * | 1979-07-26 | 1982-09-14 | Merrell Toraude & Co | Fluorinated methyl-beta-alanine derivatives and pharmaceutical compositions |
US4421767A (en) * | 1981-06-01 | 1983-12-20 | Merrell Toraude Et Compagnie | Compounds and methods for treating depression |
JP5902575B2 (en) * | 2012-07-20 | 2016-04-13 | 国立大学法人お茶の水女子大学 | Process for producing optically active fluorinated amine compound and optically active fluorinated amine compound |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3046300A (en) * | 1960-10-21 | 1962-07-24 | Merck & Co Inc | alpha-trifluoromethyloxyphenylalanines |
GB1218135A (en) * | 1967-07-28 | 1971-01-06 | Abbott Lab | Substituted phenethylamine derivatives |
-
1978
- 1978-05-30 IE IE1077/78A patent/IE47542B1/en unknown
- 1978-05-31 DK DK240678A patent/DK240678A/en not_active Application Discontinuation
- 1978-05-31 IT IT7849635A patent/IT7849635A0/en unknown
- 1978-06-01 JP JP6501578A patent/JPS5416437A/en active Pending
- 1978-06-01 DE DE7878100057T patent/DE2862407D1/en not_active Expired
- 1978-06-01 EP EP78100057A patent/EP0000034B1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IT7849635A0 (en) | 1978-05-31 |
EP0000034B1 (en) | 1984-05-23 |
DK240678A (en) | 1978-12-02 |
EP0000034A1 (en) | 1978-12-20 |
IE781077L (en) | 1978-12-01 |
JPS5416437A (en) | 1979-02-07 |
DE2862407D1 (en) | 1984-06-28 |
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