GB2000968A - Killed trypanosoma vaccine and immunologically active components of trypanosoma - Google Patents

Killed trypanosoma vaccine and immunologically active components of trypanosoma

Info

Publication number
GB2000968A
GB2000968A GB7829419A GB7829419A GB2000968A GB 2000968 A GB2000968 A GB 2000968A GB 7829419 A GB7829419 A GB 7829419A GB 7829419 A GB7829419 A GB 7829419A GB 2000968 A GB2000968 A GB 2000968A
Authority
GB
United Kingdom
Prior art keywords
trypanosoma
vaccine
killed
active components
immunologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7829419A
Other versions
GB2000968B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of GB2000968A publication Critical patent/GB2000968A/en
Application granted granted Critical
Publication of GB2000968B publication Critical patent/GB2000968B/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/005—Trypanosoma antigens
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A process for producing killed Trypanosoma cruzi organisms suitable for use in a vaccine against Chagas disease comprises treating a suspension of from 1 x 10<6> to 6 x 10<9> Trypanosoma cruzi organisms per ml, with at least 0.5 % (g/v) of an acylating agent or of a mono- or dialdehyde having up to 6 carbon atoms excluding the aldehydic carbon atom(s). Trypanosoma may be subjected to a treatment capable of breaking the cell structure, whereby the imunologically active component(s) of the Trypanosoma are freed. These are isolated from the other cell constituents and may themselves be used in a vaccine.
GB7829419A 1977-07-12 1978-07-11 Killed trypanosoma vaccine comprising them and immunologically active components thereof Expired GB2000968B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772731370 DE2731370A1 (en) 1977-07-12 1977-07-12 CHAGA'S VACCINE AND METHOD OF MANUFACTURING IT

Publications (2)

Publication Number Publication Date
GB2000968A true GB2000968A (en) 1979-01-24
GB2000968B GB2000968B (en) 1982-01-27

Family

ID=6013712

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7829419A Expired GB2000968B (en) 1977-07-12 1978-07-11 Killed trypanosoma vaccine comprising them and immunologically active components thereof

Country Status (5)

Country Link
AR (1) AR215938A1 (en)
CA (1) CA1120855A (en)
DE (1) DE2731370A1 (en)
FR (1) FR2397194A1 (en)
GB (1) GB2000968B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9028844B2 (en) 2006-03-17 2015-05-12 Vib Vzw Vaccine against Trypanosoma cruzi infection
US20210220453A1 (en) * 2016-04-14 2021-07-22 Peptcell Limited Chagas Antigens and Antibodies and Compositions, Methods and Uses Thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983003199A1 (en) * 1982-03-18 1983-09-29 Boon, Thierry Method for obtaining reduced infectivity variants from protozoan parasites, thus obtained variants and utilization thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1030777A (en) * 1963-12-06 1966-05-25 Ciba Ltd Method of preparing a vaccine against trypanosoma cruzi infections

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9028844B2 (en) 2006-03-17 2015-05-12 Vib Vzw Vaccine against Trypanosoma cruzi infection
US20210220453A1 (en) * 2016-04-14 2021-07-22 Peptcell Limited Chagas Antigens and Antibodies and Compositions, Methods and Uses Thereof

Also Published As

Publication number Publication date
FR2397194B1 (en) 1980-07-18
CA1120855A (en) 1982-03-30
FR2397194A1 (en) 1979-02-09
GB2000968B (en) 1982-01-27
DE2731370A1 (en) 1979-01-25
AR215938A1 (en) 1979-11-15

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee