GB1507243A - 13-l-leucine-14-desamide-motilin a method of preparing it and an agent containing it - Google Patents

13-l-leucine-14-desamide-motilin a method of preparing it and an agent containing it

Info

Publication number
GB1507243A
GB1507243A GB40846/76A GB4084676A GB1507243A GB 1507243 A GB1507243 A GB 1507243A GB 40846/76 A GB40846/76 A GB 40846/76A GB 4084676 A GB4084676 A GB 4084676A GB 1507243 A GB1507243 A GB 1507243A
Authority
GB
United Kingdom
Prior art keywords
motilin
leucine
desamide
preparing
agent containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB40846/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Publication of GB1507243A publication Critical patent/GB1507243A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/63—Motilins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

An L-leucine-13-motilin is prepared which contains an L-leucine in the 13-position instead of the L-norleucine according to the Main Patent. Compared to the known norleucine-motilin, the leucine-motilin has the advantage that it can be simply prepared with equally good biological activity and is particularly easily broken down in the body.
GB40846/76A 1975-10-03 1976-10-01 13-l-leucine-14-desamide-motilin a method of preparing it and an agent containing it Expired GB1507243A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2544348A DE2544348C3 (en) 1975-10-03 1975-10-03 L-leucine-13-motiline, process for its preparation and agent containing the same

Publications (1)

Publication Number Publication Date
GB1507243A true GB1507243A (en) 1978-04-12

Family

ID=5958248

Family Applications (1)

Application Number Title Priority Date Filing Date
GB40846/76A Expired GB1507243A (en) 1975-10-03 1976-10-01 13-l-leucine-14-desamide-motilin a method of preparing it and an agent containing it

Country Status (7)

Country Link
JP (1) JPS5246068A (en)
CH (1) CH615904A5 (en)
DE (1) DE2544348C3 (en)
FR (1) FR2326202A2 (en)
GB (1) GB1507243A (en)
IT (1) IT1068299B (en)
SU (1) SU593659A3 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8710184B2 (en) 2009-07-29 2014-04-29 Daiichi Sankyo Company, Limited Motilin-like peptide compound having transmucosal absorbability imparted thereto

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ189101A (en) * 1977-12-08 1984-07-06 Ortho Pharma Corp Polypeptides having the ability to induce differentiation of both th-1+ t-lymphocytes and bu-1+ b-lymphocytes;pharmaceutical compositions
US4298523A (en) * 1980-06-17 1981-11-03 Ortho Pharmaceutical Corporation Methods and compositions for preparation of H-ARG-X-Z-Y-TYR-R
CA1340265C (en) * 1985-01-18 1998-12-15 Kirston E. Koths Oxidation resistant muteins
US5695952A (en) * 1986-09-12 1997-12-09 Kyowa Hakko Kogyo Co., Ltd. Method for producing Leu13 !motilin
US5420113A (en) * 1986-09-12 1995-05-30 Kyowa Hakko Kogyo Co., Ltd. [Leu13]motilin, DNAs coding for same and methods for producing same
JP2862870B2 (en) * 1986-09-12 1999-03-03 協和醗酵工業株式会社 New peptide
JPH0742319B2 (en) * 1989-01-06 1995-05-10 株式会社三和化学研究所 Polypeptide having motilin-like activity and use thereof
JPH02311495A (en) * 1989-05-24 1990-12-27 Sanwa Kagaku Kenkyusho Co Ltd Polypeptide having motiline-like activity and its use
JPH0341033A (en) * 1989-07-07 1991-02-21 Kyowa Hakko Kogyo Co Ltd Stable preparation containing motilins
JPH0341032A (en) * 1989-07-07 1991-02-21 Kyowa Hakko Kogyo Co Ltd Aqueous solution containing motilins
US6072075A (en) * 1997-05-22 2000-06-06 The Regents Of The University Of California Guanidinylation reagents
CN107383169A (en) * 2017-04-24 2017-11-24 青岛大学 A kind of polypeptide with gastrointestinal motility stimulating activity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8710184B2 (en) 2009-07-29 2014-04-29 Daiichi Sankyo Company, Limited Motilin-like peptide compound having transmucosal absorbability imparted thereto

Also Published As

Publication number Publication date
IT1068299B (en) 1985-03-21
CH615904A5 (en) 1980-02-29
FR2326202B2 (en) 1980-04-18
JPS5246068A (en) 1977-04-12
FR2326202A2 (en) 1977-04-29
DE2544348B2 (en) 1979-04-19
DE2544348A1 (en) 1977-04-07
DE2544348C3 (en) 1979-12-13
SU593659A3 (en) 1978-02-15

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee