GB183454A - - Google Patents

Info

Publication number
GB183454A
GB183454A GB19511/22A GB1951122A GB183454A GB 183454 A GB183454 A GB 183454A GB 19511/22 A GB19511/22 A GB 19511/22A GB 1951122 A GB1951122 A GB 1951122A GB 183454 A GB183454 A GB 183454A
Authority
GB
United Kingdom
Prior art keywords
carboxylic acid
acid
chloride
converted
anthranilic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB19511/22A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cf Boehringer And Sorhne
Original Assignee
Cf Boehringer And Sorhne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cf Boehringer And Sorhne filed Critical Cf Boehringer And Sorhne
Publication of GB183454A publication Critical patent/GB183454A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Anthranilic acid derivatives substituted in the amino group are obtained by treating anthranilic acid or its derivatives or substitution products with either a quinoline carboxylic acid halide or with a chlor quinoline carboxylic acid or with a corresponding substituted quinoline carboxylic acid. The products may be further converted into mono- or di-alkyl esters and are of value in the treatment of gout. According to examples:-(1) 2-phenylquinoline-4-carboxylic acid is converted into its chloride by thionyl chloride and heated with anthranilic acid in benzene solution; (2) 2-phenyl-6-methylquinoline-4-carboxylic acid is similarly converted to the chloride and condensed with anthranilic acid or its methyl ester; (3) 2-chloroquinoline-4-carboxylic acid is condensed with anthranilic acid in aqueous suspension and the product purified by dissolving in soda solution and reprecipitating; the product is then converted into its dimethyl ester by esterifying with methyl alcohol and hydrochloric acid gas; (4) 2-phenyl-quinoline-4-carboxylic acid chloride is condensed with 5-chlor-1-aminobenzene-2-carboxylic acid in benzene solution, or with 5-oxy-2-aminobenzene-1-carboxylic acid in aqueous suspension.
GB19511/22A 1921-07-20 1922-07-15 Expired GB183454A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE183454T 1921-07-20

Publications (1)

Publication Number Publication Date
GB183454A true GB183454A (en) 1923-11-14

Family

ID=31892860

Family Applications (1)

Application Number Title Priority Date Filing Date
GB19511/22A Expired GB183454A (en) 1921-07-20 1922-07-15

Country Status (1)

Country Link
GB (1) GB183454A (en)

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