GB1589237A - Substituted 6 - phenyl - 1,2,4 - triazolo-((4,3-b)pyridazines - Google Patents

Substituted 6 - phenyl - 1,2,4 - triazolo-((4,3-b)pyridazines Download PDF

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Publication number
GB1589237A
GB1589237A GB39619/77A GB3961977A GB1589237A GB 1589237 A GB1589237 A GB 1589237A GB 39619/77 A GB39619/77 A GB 39619/77A GB 3961977 A GB3961977 A GB 3961977A GB 1589237 A GB1589237 A GB 1589237A
Authority
GB
United Kingdom
Prior art keywords
compound
methyl
mixture
chloro
pyridazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB39619/77A
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English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/725,597 external-priority patent/US4230705A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of GB1589237A publication Critical patent/GB1589237A/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/12—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB39619/77A 1976-09-22 1977-09-22 Substituted 6 - phenyl - 1,2,4 - triazolo-((4,3-b)pyridazines Expired GB1589237A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/725,597 US4230705A (en) 1976-09-22 1976-09-22 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety
US73039576A 1976-10-07 1976-10-07
US73547576A 1976-10-26 1976-10-26

Publications (1)

Publication Number Publication Date
GB1589237A true GB1589237A (en) 1981-05-07

Family

ID=27419081

Family Applications (1)

Application Number Title Priority Date Filing Date
GB39619/77A Expired GB1589237A (en) 1976-09-22 1977-09-22 Substituted 6 - phenyl - 1,2,4 - triazolo-((4,3-b)pyridazines

Country Status (19)

Country Link
JP (1) JPS5340798A (de)
AR (2) AR218036A1 (de)
AT (1) AT360034B (de)
AU (1) AU513760B2 (de)
BG (1) BG29287A3 (de)
CA (1) CA1080712A (de)
DD (1) DD132586A5 (de)
DE (1) DE2741763A1 (de)
DK (1) DK417377A (de)
ES (3) ES462543A1 (de)
FI (1) FI772802A (de)
FR (1) FR2442848A1 (de)
GB (1) GB1589237A (de)
GR (1) GR71699B (de)
LU (1) LU78150A1 (de)
NL (1) NL7710389A (de)
NO (1) NO773245L (de)
PT (1) PT67067B (de)
RO (1) RO72226A (de)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0223974A1 (de) * 1985-10-31 1987-06-03 American Cyanamid Company N-Substituierte N-[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)-phenyl]-alkanamide, Carbamate und Harnstoffe
WO1999037644A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
WO1999037646A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
WO1999037647A1 (en) * 1998-01-22 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
WO1999037648A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
WO1999037645A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
WO1999037649A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR70309B (de) * 1979-10-29 1982-09-08 Dow Chemical Co
FR2473522A1 (fr) * 1980-01-16 1981-07-17 Synthelabo Nouveaux derives substitues de dihydro-2,3 imidazo(1,2-b)pyridazines et les medicaments, utiles notamment comme antidepresseurs, qui en contiennent
EP0036711B1 (de) * 1980-03-22 1985-12-04 Fbc Limited Heterocyclische pestizide Verbindungen, Verfahren zu ihrer Herstellung, sie enthaltende Zusammensetzungen und ihre Verwendung
DE3217325A1 (de) * 1982-05-08 1983-11-10 Hoechst Ag, 6230 Frankfurt 3-amino-6-aryl-1,2,4-triazolo(4,3-b)-pyridazine, ihre herstellung und ihre verwendung
US4487930A (en) * 1982-09-07 1984-12-11 The Dow Chemical Company 6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines
FR2562071B1 (fr) * 1984-03-30 1986-12-19 Sanofi Sa Triazolo(4,3-b)pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant
US4767765A (en) * 1985-10-31 1988-08-30 American Cyanamid Company N-substituted-N-[3-(1,2,4-triazolo-[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
EA002436B1 (ru) 1996-07-25 2002-04-25 Мерк Шарп Энд Домэ Лимитед Замещенные производные триазоло-пиридазина в качестве лигандов рецепторов гамк
AU746866B2 (en) 1998-01-14 2002-05-02 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
GB9801538D0 (en) 1998-01-23 1998-03-25 Merck Sharp & Dohme Pharmaceutical product
CN1922183B (zh) * 2004-02-18 2010-05-26 万有制药株式会社 含氮的稠合杂芳环衍生物
CN110337295B (zh) 2016-11-28 2023-06-09 普拉克西斯精密药物股份有限公司 化合物以及它们的使用方法
TWI831786B (zh) 2018-05-30 2024-02-11 美商普雷西斯精密藥品公司 離子通道調節劑
US11773099B2 (en) 2019-05-28 2023-10-03 Praxis Precision Medicines, Inc. Compounds and their methods of use
US11505554B2 (en) 2019-05-31 2022-11-22 Praxis Precision Medicines, Inc. Substituted pyridines as ion channel modulators

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0223974A1 (de) * 1985-10-31 1987-06-03 American Cyanamid Company N-Substituierte N-[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)-phenyl]-alkanamide, Carbamate und Harnstoffe
US6319924B1 (en) 1998-01-21 2001-11-20 Merck Sharp & Dohme Ltd. Triazolo-pyridazine derivatives as ligands for GABA receptors
WO1999037646A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
WO1999037648A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
WO1999037645A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
WO1999037649A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
US6303605B1 (en) 1998-01-21 2001-10-16 Merck Sharp & Dohme Ltd. Triazolo-pyridazine derivatives as ligands for GABA receptors
WO1999037644A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
US6355798B1 (en) 1998-01-21 2002-03-12 Merck Sharp & Dohme Ltd. Triazolo-pyridazine derivatives as ligands for GABA receptors
US6579875B1 (en) 1998-01-21 2003-06-17 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
US6699859B1 (en) 1998-01-21 2004-03-02 Merck Sharp & Dohme Ltd. Triazolo-pyridazine derivatives as ligands for GABA receptors
US6828322B2 (en) 1998-01-21 2004-12-07 Merck Sharp & Dohme Ltd. Triazolo-pyridazine derivatives as ligands for GABA receptors
WO1999037647A1 (en) * 1998-01-22 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
US6291460B1 (en) 1998-01-22 2001-09-18 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors

Also Published As

Publication number Publication date
NL7710389A (nl) 1978-03-28
NO773245L (no) 1978-03-28
FR2442848A1 (fr) 1980-06-27
AU2899577A (en) 1979-03-29
DK417377A (da) 1978-03-23
AT360034B (de) 1980-12-10
DE2741763A1 (de) 1978-03-23
GR71699B (de) 1983-06-21
FI772802A (fi) 1978-03-23
RO72226A (ro) 1982-09-09
LU78150A1 (de) 1978-01-23
PT67067A (en) 1977-10-01
ATA677577A (de) 1980-05-15
ES477799A1 (es) 1980-04-01
JPS5340798A (en) 1978-04-13
PT67067B (en) 1979-02-19
AR218036A1 (es) 1980-05-15
AR217886A1 (es) 1980-04-30
AU513760B2 (en) 1980-12-18
BG29287A3 (en) 1980-10-15
ES477800A1 (es) 1979-10-16
CA1080712A (en) 1980-07-01
DD132586A5 (de) 1978-10-11
ES462543A1 (es) 1979-06-16

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CSNS Application of which complete specification have been accepted and published, but patent is not sealed