GB1571133A - Immuniological adjuvant peptidoglycans compounds and methods of preparation thereof - Google Patents

Immuniological adjuvant peptidoglycans compounds and methods of preparation thereof Download PDF

Info

Publication number
GB1571133A
GB1571133A GB16488/77A GB1648877A GB1571133A GB 1571133 A GB1571133 A GB 1571133A GB 16488/77 A GB16488/77 A GB 16488/77A GB 1648877 A GB1648877 A GB 1648877A GB 1571133 A GB1571133 A GB 1571133A
Authority
GB
United Kingdom
Prior art keywords
isoglutamine
deoxy
glucos
acetyl
acetamido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB16488/77A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/680,618 external-priority patent/US4082736A/en
Priority claimed from US05/680,260 external-priority patent/US4082735A/en
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of GB1571133A publication Critical patent/GB1571133A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB16488/77A 1976-04-26 1977-04-20 Immuniological adjuvant peptidoglycans compounds and methods of preparation thereof Expired GB1571133A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/680,618 US4082736A (en) 1976-04-26 1976-04-26 Novel immunological adjuvant compounds and methods of preparation thereof
US05/680,260 US4082735A (en) 1976-04-26 1976-04-26 Novel immunological adjuvant compounds and methods of preparation thereof
US77720477A 1977-03-14 1977-03-14

Publications (1)

Publication Number Publication Date
GB1571133A true GB1571133A (en) 1980-07-09

Family

ID=27418368

Family Applications (1)

Application Number Title Priority Date Filing Date
GB16488/77A Expired GB1571133A (en) 1976-04-26 1977-04-20 Immuniological adjuvant peptidoglycans compounds and methods of preparation thereof

Country Status (8)

Country Link
JP (2) JPS52131526A (enExample)
CH (1) CH636887A5 (enExample)
DE (1) DE2718010A1 (enExample)
ES (1) ES458197A1 (enExample)
FR (1) FR2349600A1 (enExample)
GB (1) GB1571133A (enExample)
NL (1) NL7704555A (enExample)
SE (1) SE445924B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108884132A (zh) * 2015-12-10 2018-11-23 巴拉特生物技术国际有限公司 新颖的胞壁酰肽衍生物化合物、其合成及其用途
CN108883080A (zh) * 2015-12-15 2018-11-23 巴拉特生物技术国际有限公司 新颖的胞壁酰肽衍生物化合物、其合成及其用途
US12134664B2 (en) 2015-12-10 2024-11-05 Bharat Biotech International Ltd. Muramyl peptide derivatives

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2862107D1 (en) * 1977-12-02 1982-11-18 Takeda Chemical Industries Ltd Glucosamine-peptide derivatives and their pharmaceutical compositions
FR2442241A2 (fr) * 1978-03-20 1980-06-20 Anvar Nouveaux composes esters de muramyl-peptide, leur preparation et les compositions pharmaceutiques les contenant, notamment sous forme de liposomes
FR2420545A1 (fr) * 1978-03-20 1979-10-19 Anvar Nouveaux esters de l'acide n-acetyl-muramyl-aminoacyl-glutamique ou des derives de substitution de celui-ci a proprietes anti-infectieuses et/ou d'adjuvants immunologiques
US4335111A (en) * 1978-12-22 1982-06-15 Agence National De Valorisation De La Recherche (Anvar) Compounds associating peptidyl of aminoacyl residues to lipophilic groups and pharmaceutical compositions containing said new compounds
US4256735A (en) * 1979-01-29 1981-03-17 Merck & Co., Inc. Immunologically active dipeptidyl saccharides and methods of preparation
FR2449697A1 (fr) * 1979-02-20 1980-09-19 Anvar Nouveaux muramyl-peptides substitues sur un azote peptidique et medicaments les contenant
CA1185237A (en) * 1979-02-28 1985-04-09 Yuichi Yamamura 6-deoxyglucosamine-peptide derivatives, their production and use
FR2482957A2 (fr) * 1979-06-29 1981-11-27 Rhone Poulenc Ind Nouveaux dipeptides, leur preparation et les medicaments qui les contiennent
US4406889A (en) * 1980-02-15 1983-09-27 Ciba-Geigy Corporation Derivatives of aldohexoses, intermediates, processes for their manufacture, preparations containing such compounds, and their use
US4368190A (en) * 1980-04-17 1983-01-11 Merck & Co., Inc. Immunologically active dipeptidyl 4-O-,6-O-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation
JPS6042398A (ja) * 1983-08-18 1985-03-06 Toshiyuki Hamaoka ムラミルジペプチド活性エステル誘導体
US4777160A (en) * 1986-09-18 1988-10-11 Bristol-Myers BU-2867T peptide antibiotics

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH613709A5 (en) * 1975-12-10 1979-10-15 Ciba Geigy Ag Process for the preparation of glucosamine derivatives

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108884132A (zh) * 2015-12-10 2018-11-23 巴拉特生物技术国际有限公司 新颖的胞壁酰肽衍生物化合物、其合成及其用途
EP3387005A4 (en) * 2015-12-10 2019-07-10 Bharat Biotech International Limited NOVEL MURAMYLPEPTIDE DERIVATIVE COMPOUND, SYNTHESIS AND USES THEREOF
US10927147B2 (en) 2015-12-10 2021-02-23 Bharat Biotech International Limited Muramyl peptide derivative compound, synthesis and uses thereof
CN108884132B (zh) * 2015-12-10 2022-10-04 巴拉特生物技术国际有限公司 胞壁酰肽衍生物化合物、其合成及其用途
US12134664B2 (en) 2015-12-10 2024-11-05 Bharat Biotech International Ltd. Muramyl peptide derivatives
CN108883080A (zh) * 2015-12-15 2018-11-23 巴拉特生物技术国际有限公司 新颖的胞壁酰肽衍生物化合物、其合成及其用途
EP3389643A4 (en) * 2015-12-15 2019-07-10 Bharat Biotech International Limited NOVEL MURAMYLPEPTIDE DERIVATIVE COMPOUND, SYNTHESIS AND USES THEREOF
US10576147B2 (en) 2015-12-15 2020-03-03 Bharat Biotech International Limited Muramyl peptide derivative compound, synthesis and uses thereof
CN108883080B (zh) * 2015-12-15 2021-12-21 巴拉特生物技术国际有限公司 胞壁酰肽衍生物化合物、其合成及其用途

Also Published As

Publication number Publication date
NL7704555A (nl) 1977-10-28
DE2718010C2 (enExample) 1990-11-08
FR2349600B1 (enExample) 1981-01-02
FR2349600A1 (fr) 1977-11-25
DE2718010A1 (de) 1977-11-10
SE445924B (sv) 1986-07-28
SE7704609L (sv) 1977-10-27
JPH02138290A (ja) 1990-05-28
JPS638119B2 (enExample) 1988-02-19
ES458197A1 (es) 1978-08-16
JPS52131526A (en) 1977-11-04
CH636887A5 (en) 1983-06-30
JPH0371440B2 (enExample) 1991-11-13

Similar Documents

Publication Publication Date Title
US4082735A (en) Novel immunological adjuvant compounds and methods of preparation thereof
US4082736A (en) Novel immunological adjuvant compounds and methods of preparation thereof
GB1571133A (en) Immuniological adjuvant peptidoglycans compounds and methods of preparation thereof
CA1262400A (en) Process for the manufacture of glucosamine derivatives
DE3750184T2 (de) Peptidylaminodiole.
US4742048A (en) Tetrapeptides and pentapeptides, their preparation and compositions containing them
US4369178A (en) Glucosamine peptide derivatives, their production and use
CA1185237A (en) 6-deoxyglucosamine-peptide derivatives, their production and use
US4401658A (en) Tri-, tetra, and penta-peptides, their preparation and compositions containing them
CA1174232A (en) Immunologically active dipeptidyl 4-o-,6-o-acyl-2- amino-2-deoxy-d-glucose derivatives and methods for their preparation
CA1173430A (en) Immunologically active dipeptidyl 2-amino-1,2-dideoxy d-glucose derivatives and methods of preparation
GB2053232A (en) Dipeptides their preparation and the medicaments in which they are present
US4128542A (en) Peptide derivatives
US4548923A (en) Muramyl peptides and processes for their manufacture
US4640911A (en) Acylated sugar derivatives, processes for their manufacture, and their use
CA1185236A (en) Immunologically active dipeptidyl saccharides and methods of preparation
US4606857A (en) Muramyldipeptide derivatives
SU1346046A3 (ru) Способ получени н-бутиловых эфиров производных N-ацетилмурамилпептидов
HK16081A (en) Novel immunological adjuvant peptidoglycans compounds and methods of preparation thereof
DD240546A5 (de) Verfahren zur herstellung von neuen petid-substituierten heterocyclischen immunstimulatien
EP0013856B1 (en) New compounds associating peptidyl or aminoacyl residues to lipophilic groups and pharmaceutical compositions containing said new compounds
Waldmann et al. 1, 3-Dithian-2-ylmethyl esters as two-step carboxy-protecting groups in the synthesis of N-glycopeptides
GB2053230A (en) Tripeptides their preparation and compositions containing them
US4515715A (en) L-Alanyl-D-isoglutamine adamantylamide
CA1262015A (en) Acylated sugar derivatives, processes for their manufacture, and their use

Legal Events

Date Code Title Description
PS Patent sealed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19970419