GB1555555A - Cyano acetic acid anilide derivatives process for their manufacture and compositions containing them - Google Patents

Cyano acetic acid anilide derivatives process for their manufacture and compositions containing them

Info

Publication number
GB1555555A
GB1555555A GB23437/76A GB2343776A GB1555555A GB 1555555 A GB1555555 A GB 1555555A GB 23437/76 A GB23437/76 A GB 23437/76A GB 2343776 A GB2343776 A GB 2343776A GB 1555555 A GB1555555 A GB 1555555A
Authority
GB
United Kingdom
Prior art keywords
manufacture
acetic acid
compositions containing
acid anilide
anilide derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23437/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of GB1555555A publication Critical patent/GB1555555A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB23437/76A 1975-06-05 1976-06-07 Cyano acetic acid anilide derivatives process for their manufacture and compositions containing them Expired GB1555555A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2524929A DE2524929C3 (de) 1975-06-05 1975-06-05 2-Hydroxyäthylidencyanessigsäureanilide, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Mittel

Publications (1)

Publication Number Publication Date
GB1555555A true GB1555555A (en) 1979-11-14

Family

ID=5948272

Family Applications (1)

Application Number Title Priority Date Filing Date
GB23437/76A Expired GB1555555A (en) 1975-06-05 1976-06-07 Cyano acetic acid anilide derivatives process for their manufacture and compositions containing them

Country Status (15)

Country Link
US (1) US4061767A (enExample)
JP (1) JPS6032620B2 (enExample)
AT (1) AT343641B (enExample)
BE (1) BE842688A (enExample)
CA (1) CA1082202A (enExample)
CH (1) CH627444A5 (enExample)
DE (1) DE2524929C3 (enExample)
DK (1) DK157078C (enExample)
FR (1) FR2313031A1 (enExample)
GB (1) GB1555555A (enExample)
IE (1) IE43004B1 (enExample)
IT (1) IT1063593B (enExample)
LU (1) LU75075A1 (enExample)
MX (1) MX3170E (enExample)
NL (2) NL186239C (enExample)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
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WO1980000964A1 (en) * 1978-11-03 1980-05-15 American Cyanamid Co Anti-inflammatory agents including 2-carbonyl-3-hydroxy-2-alkenonitriles
US4181677A (en) * 1978-12-13 1980-01-01 American Cyanamid Company 2-Benzoyl-3-alkoxy-2-alkenonitriles
US4173650A (en) * 1978-11-03 1979-11-06 American Cyanamid Company Cis-2-benzoyl-3-hydroxy-2-alkenonitriles as anti-inflammatory agents
US4259256A (en) * 1978-12-13 1981-03-31 American Cyanamid Company 2-Benzoyl-3-dimethylamino-2-alkenonitriles
DE3070951D1 (en) * 1979-06-11 1985-09-12 Ciba Geigy Ag Alphacarbamoyl-pyrrolpropionitriles, process for their preparation and pharmaceutical preparations containing them
US4256759A (en) * 1979-06-11 1981-03-17 Ciba-Geigy Corporation Alphacarbamoyl-pyrrolpropionitriles
US4277420A (en) * 1979-09-24 1981-07-07 Monsanto Company Ephedrine and pseudoephedrine precursors
US4254048A (en) * 1979-12-17 1981-03-03 American Cyanamid Company Substituted phenyl alkylidene acetoacetonitriles
US4254047A (en) * 1979-12-17 1981-03-03 American Cyanamid Company Substituted phenyl-2-cyano-2-thioalkenoic acid esters
US4254049A (en) * 1979-12-17 1981-03-03 American Cyanamid Company Substituted phenyl-2-cyano-2-alkenoic acid esters
US4435407A (en) 1982-01-07 1984-03-06 Ciba-Geigy Corporation Certain substituted β-oxo-α-carbamoylpyrrolepropionitriles
US4644010A (en) * 1982-09-28 1987-02-17 Ciba-Geigy Corporation Certain β-oxo-α-carbamoylpyrrolepropionitriles
DE3247454A1 (de) * 1982-12-22 1984-06-28 Laboratorios Bago S.A., Buenos Aires Substituierte 3-phenyl-5-methyl-isoxazol-4-carboxy-anilide, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3534440A1 (de) * 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
US5268382A (en) * 1985-09-27 1993-12-07 Hoechst Aktiengesellschaft Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus
GB8619432D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
GB8619433D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
US4888357A (en) * 1988-01-26 1989-12-19 Bristol-Myers Company Antiarthritic β-cycloalkyl-β-oxopropionitriles
US4975462A (en) * 1988-07-29 1990-12-04 Bristol-Myers Company Antiarthritic α-arylcarbamoyl cyanoacetic acid derivatives
DD297328A5 (de) 1989-08-18 1992-01-09 �������@���������k���Kk�� 5-methyl-isoxalol-4-carbonsaeureanilide und 2 hydroxyethyliden-cyanoessigsaeureanilide zur behandlung von augenerkrankungen
US5583150A (en) * 1989-08-18 1996-12-10 Alcon Laboratories, Inc. 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic anilides for the treatment of ocular diseases
US5034410A (en) * 1989-10-11 1991-07-23 Syntex (U.S.A.) Inc. Anthelmintically active benzenepropanamide derivatives
RU2142937C1 (ru) * 1990-05-18 1999-12-20 Хехст АГ Амиды органических кислот, способ их получения и фармацевтическая композиция
ZA913762B (en) 1990-05-18 1992-01-29 Hoechst Ag Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides,pharmaceuticals containing these compounds and their use
CA2058185A1 (en) * 1990-12-24 1992-06-25 Manfred Schudok Process for the acylation of alcohols with immobilized enzymes
US6133301A (en) * 1991-08-22 2000-10-17 Aventis Pharma Deutschland Gmbh Pharmaceuticals for the treatment of rejection reactions in organ transplantations
DE4127737A1 (de) 1991-08-22 1993-02-25 Hoechst Ag Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen
IL102790A (en) * 1991-09-17 1996-01-31 Roussel Uclaf 3-Cycloalkyl-prop-2- enamide derivatives
NZ244814A (en) * 1991-10-23 1994-06-27 Hoechst Ag N-phenyl-2-cyano-3-hydroxycrotonamide derivatives and pharmaceutical compositions
GB9200275D0 (en) * 1992-01-08 1992-02-26 Roussel Lab Ltd Chemical compounds
GB9209330D0 (en) * 1992-04-30 1992-06-17 Roussel Lab Ltd Chemical compounds
GB9300083D0 (en) 1993-01-05 1993-03-03 Roussel Lab Ltd Chemical compounds
TW314467B (enExample) * 1993-03-31 1997-09-01 Hoechst Ag
ATE157100T1 (de) 1993-06-03 1997-09-15 Therapeutic Antibodies Inc Antikoerperfragmente in therapie
GB9313365D0 (en) * 1993-06-29 1993-08-11 Roussel Lab Ltd Chemical compounds
GB9322781D0 (en) * 1993-11-04 1993-12-22 Roussel Lab Ltd Aromatic amides
LT3589B (en) 1993-11-30 1995-12-27 Hoechst Ag Using of known combination for treatment of rejection reaction by transplantation of organs
US5700823A (en) * 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
US5519042A (en) * 1994-01-13 1996-05-21 Hoechst Aktiengesellschaft Method of treating hyperproliferative vascular disease
US6331555B1 (en) 1995-06-01 2001-12-18 University Of California Treatment of platelet derived growth factor related disorders such as cancers
DE19539638A1 (de) * 1995-10-25 1997-04-30 Hoechst Ag Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen
DE19547648A1 (de) * 1995-12-20 1997-06-26 Hoechst Ag Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate
US5856330A (en) * 1996-07-31 1999-01-05 Hoechst Aktiengesellschaft Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin
US6011051A (en) * 1996-07-31 2000-01-04 Hoechst Aktiengesellschaft Use of isoxazole and crotonamide derivatives for the modulation of apoptosis
US5981536A (en) * 1996-07-31 1999-11-09 Hoechst Aktiengesellschaft Use of xanthine derivatives for the modulation of apoptosis
US6316479B1 (en) 1997-05-19 2001-11-13 Sugen, Inc. Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders
DE59801792D1 (de) * 1997-08-08 2001-11-22 Aventis Pharma Gmbh Kristallform von N-(4-Trifluormethylphenyl)-5-methylisoxazol-4-carbonsäureamid
US6355678B1 (en) * 1998-06-29 2002-03-12 Parker Hughes Institute Inhibitors of the EGF-receptor tyrosine kinase and methods for their use
US20050255071A1 (en) * 1998-12-10 2005-11-17 Aventis Pharma Deutschland Gmbh Preparation having improved therapeutic breadth comprising nucleotide synthesis inhibitors
GB0123571D0 (en) * 2001-04-05 2001-11-21 Aventis Pharm Prod Inc Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis
DE10132308A1 (de) * 2001-07-06 2003-01-30 Aventis Behring Gmbh Kombinationspräparat zur Therapie von immunologischen Erkrankungen
WO2003006424A1 (en) 2001-07-10 2003-01-23 4Sc Ag Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
US20050158371A1 (en) * 2002-02-12 2005-07-21 Sumitomo Pharmaceuticals Co., Ltd. Novel external agent
NZ541382A (en) 2002-12-23 2009-04-30 4Sc Ag Aromatic compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
UA108760C2 (uk) 2010-07-01 2015-06-10 Кальцієві солі сполуки як протизапальні, імуномодулюючі та антипроліферативні засоби
JP2016537360A (ja) 2013-11-22 2016-12-01 ジェンザイム・コーポレーション 神経変性疾患を治療するための新規な方法
RU2722316C2 (ru) * 2015-06-17 2020-05-29 Биокон Лимитед Новый способ получения терифлуномида
IL277326B2 (en) 2018-03-16 2024-03-01 Immunic Ag Calcium salt polymorph inhibitors of dihydroorotate dehydrogenase and processes for preparing same
AU2021260040A1 (en) 2020-04-21 2022-11-17 Immunic Ag Vidofludimus for use in the treatment or prevention of viral diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2288863A (en) * 1940-02-27 1942-07-07 Hoffmann La Roche Process for the manufacture of substituted amides of 3,5-dimethylisoxazole-4-carboxylic acid
BE506549A (enExample) * 1950-10-19

Also Published As

Publication number Publication date
NL186239C (nl) 1990-10-16
IE43004B1 (en) 1980-12-03
MX3170E (es) 1980-06-05
DK248476A (da) 1976-12-06
CH627444A5 (de) 1982-01-15
JPS527929A (en) 1977-01-21
BE842688A (fr) 1976-12-08
CA1082202A (en) 1980-07-22
FR2313031A1 (fr) 1976-12-31
US4061767A (en) 1977-12-06
DK157078C (da) 1990-04-09
DE2524929C3 (de) 1980-10-09
FR2313031B1 (enExample) 1979-10-12
IE43004L (en) 1976-12-05
DE2524929B2 (de) 1980-01-31
NL186239B (nl)
DK157078B (da) 1989-11-06
IT1063593B (it) 1985-02-11
LU75075A1 (enExample) 1977-03-07
NL7605845A (en) 1976-12-07
AT343641B (de) 1978-06-12
JPS6032620B2 (ja) 1985-07-29
ATA413576A (de) 1977-10-15
DE2524929A1 (de) 1976-12-16

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years

Effective date: 19960606