GB1549320A - Aminoglycoside antibiotic compounds and process for preparing the same - Google Patents

Aminoglycoside antibiotic compounds and process for preparing the same

Info

Publication number
GB1549320A
GB1549320A GB9859/76A GB985976A GB1549320A GB 1549320 A GB1549320 A GB 1549320A GB 9859/76 A GB9859/76 A GB 9859/76A GB 985976 A GB985976 A GB 985976A GB 1549320 A GB1549320 A GB 1549320A
Authority
GB
United Kingdom
Prior art keywords
acid
preparing
addition
same
symbols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB9859/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labaz SA
Original Assignee
Labaz SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz SA filed Critical Labaz SA
Priority to GB9859/76A priority Critical patent/GB1549320A/en
Priority to FR7706178A priority patent/FR2343751A1/en
Priority to NL7702341A priority patent/NL7702341A/en
Priority to BE175514A priority patent/BE852142A/en
Priority to IT21025/77A priority patent/IT1114756B/en
Priority to CA273,830A priority patent/CA1068226A/en
Priority to SE7702721A priority patent/SE433091B/en
Priority to NO770852A priority patent/NO148558C/en
Priority to CH305177A priority patent/CH620944A5/en
Priority to PL1977196605A priority patent/PL104557B1/en
Priority to SU772458602A priority patent/SU952109A3/en
Priority to JP52027528A priority patent/JPS5937077B2/en
Priority to HU77LA910A priority patent/HU178039B/en
Priority to DE2710694A priority patent/DE2710694C2/en
Priority to ES456743A priority patent/ES456743A1/en
Priority to DD7700197807A priority patent/DD130047A5/en
Publication of GB1549320A publication Critical patent/GB1549320A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/232—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with at least three saccharide radicals in the molecule, e.g. lividomycin, neomycin, paromomycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

New aminocyclitol aminoglycoside derivatives of formula I, in which the symbols have the meaning given in Claim 1, as well as their addition salts with acid, are obtained by culturing a deoxystreptamine-negative mutant of Streptomyces in a nutrient medium containing, in addition to the sources of ordinary essential atoms, a streptamine or a mixture of gentamines of formula IIA whose symbols are also defined in Claim 1. The free base may then be treated and isolated from the culture medium using an organic or inorganic acid so as to prepare an addition salt with a nontoxic acid. The new compounds thus obtained are antibiotics capable of attacking microorganisms which have become resistant to antibiotics commonly used. <IMAGE>
GB9859/76A 1976-03-11 1976-03-11 Aminoglycoside antibiotic compounds and process for preparing the same Expired GB1549320A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
GB9859/76A GB1549320A (en) 1976-03-11 1976-03-11 Aminoglycoside antibiotic compounds and process for preparing the same
FR7706178A FR2343751A1 (en) 1976-03-11 1977-03-03 NEW AMINOGLYCOSIDE DERIVATIVES OF AMINOCYCLITOL, THEIR PREPARATION PROCESS AND THE THERAPEUTIC COMPOSITIONS CONTAINING THEM
NL7702341A NL7702341A (en) 1976-03-11 1977-03-04 PROCESS FOR THE PREPARATION OF NEW AMINOGLYCOSIDE AMINOCYCLITOL DERIVATIVES.
BE175514A BE852142A (en) 1976-03-11 1977-03-07 NEW AMINOGLYCOSIDE DERIVATIVES OF AMINOCYCLITOL
IT21025/77A IT1114756B (en) 1976-03-11 1977-03-08 AMMINOGLICOSIDE-AMINOCYCLITOL DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION
CA273,830A CA1068226A (en) 1976-03-11 1977-03-10 Aminoglycoside-aminocyclitol derivatives and process for preparing the same
SE7702721A SE433091B (en) 1976-03-11 1977-03-10 ANALOGY PROCEDURE FOR PREPARING NEW PHARMACOLOGICAL EFFECT AMINOGLYCOSIDE AMINOCYCLLITOL DERIVATIVES
NO770852A NO148558C (en) 1976-03-11 1977-03-10 ANALOGY PROCEDURE FOR THE PREPARATION OF AMINOGLYCOSIDE AMINOCYCLITOL DERIVATIVES
CH305177A CH620944A5 (en) 1976-03-11 1977-03-10 Process for the preparation of new aminocyclitol aminoglycoside derivatives
PL1977196605A PL104557B1 (en) 1976-03-11 1977-03-11 METHOD OF MAKING NEW AMINOGLYCOSIDE DERIVATIVES OF AMINOCYCLITOL
SU772458602A SU952109A3 (en) 1976-03-11 1977-03-11 Process for producing derivatives of aminoglycozide-aminocylitole
JP52027528A JPS5937077B2 (en) 1976-03-11 1977-03-11 6-deoxyneomycin, its production method, and antibacterial agents containing it as an active ingredient
HU77LA910A HU178039B (en) 1976-03-11 1977-03-11 Process for preparing new amino-glycoside derivatives
DE2710694A DE2710694C2 (en) 1976-03-11 1977-03-11 Aminocyclitol glycosides, processes for their production and preparations containing these compounds
ES456743A ES456743A1 (en) 1976-03-11 1977-03-11 Aminoglycoside antibiotic compounds and process for preparing the same
DD7700197807A DD130047A5 (en) 1976-03-11 1977-03-11 PROCESS FOR THE PREPARATION OF NEW AMINOGLY COSIDAMINO CYCLITOL DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9859/76A GB1549320A (en) 1976-03-11 1976-03-11 Aminoglycoside antibiotic compounds and process for preparing the same

Publications (1)

Publication Number Publication Date
GB1549320A true GB1549320A (en) 1979-08-01

Family

ID=9880112

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9859/76A Expired GB1549320A (en) 1976-03-11 1976-03-11 Aminoglycoside antibiotic compounds and process for preparing the same

Country Status (16)

Country Link
JP (1) JPS5937077B2 (en)
BE (1) BE852142A (en)
CA (1) CA1068226A (en)
CH (1) CH620944A5 (en)
DD (1) DD130047A5 (en)
DE (1) DE2710694C2 (en)
ES (1) ES456743A1 (en)
FR (1) FR2343751A1 (en)
GB (1) GB1549320A (en)
HU (1) HU178039B (en)
IT (1) IT1114756B (en)
NL (1) NL7702341A (en)
NO (1) NO148558C (en)
PL (1) PL104557B1 (en)
SE (1) SE433091B (en)
SU (1) SU952109A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109111376B (en) * 2018-09-18 2021-09-14 四川医立特生物医药有限公司 2, 5-dideoxy streptomycin derivative and application thereof

Also Published As

Publication number Publication date
HU178039B (en) 1982-02-28
BE852142A (en) 1977-09-07
DD130047A5 (en) 1978-03-01
NO148558B (en) 1983-07-25
PL104557B1 (en) 1979-08-31
FR2343751A1 (en) 1977-10-07
SU952109A3 (en) 1982-08-15
PL196605A1 (en) 1978-02-13
CA1068226A (en) 1979-12-18
SE7702721L (en) 1977-09-12
SE433091B (en) 1984-05-07
JPS5937077B2 (en) 1984-09-07
NL7702341A (en) 1977-09-13
ES456743A1 (en) 1978-06-01
FR2343751B1 (en) 1981-10-16
JPS52142044A (en) 1977-11-26
NO770852L (en) 1977-09-13
NO148558C (en) 1983-11-02
DE2710694A1 (en) 1977-09-15
CH620944A5 (en) 1980-12-31
IT1114756B (en) 1986-01-27
DE2710694C2 (en) 1985-08-01

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee