ES456743A1 - Aminoglycoside antibiotic compounds and process for preparing the same - Google Patents
Aminoglycoside antibiotic compounds and process for preparing the sameInfo
- Publication number
- ES456743A1 ES456743A1 ES456743A ES456743A ES456743A1 ES 456743 A1 ES456743 A1 ES 456743A1 ES 456743 A ES456743 A ES 456743A ES 456743 A ES456743 A ES 456743A ES 456743 A1 ES456743 A1 ES 456743A1
- Authority
- ES
- Spain
- Prior art keywords
- acid
- preparing
- addition
- same
- symbols
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
- C07H15/232—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with at least three saccharide radicals in the molecule, e.g. lividomycin, neomycin, paromomycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
New aminocyclitol aminoglycoside derivatives of formula I, in which the symbols have the meaning given in Claim 1, as well as their addition salts with acid, are obtained by culturing a deoxystreptamine-negative mutant of Streptomyces in a nutrient medium containing, in addition to the sources of ordinary essential atoms, a streptamine or a mixture of gentamines of formula IIA whose symbols are also defined in Claim 1. The free base may then be treated and isolated from the culture medium using an organic or inorganic acid so as to prepare an addition salt with a nontoxic acid. The new compounds thus obtained are antibiotics capable of attacking microorganisms which have become resistant to antibiotics commonly used.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9859/76A GB1549320A (en) | 1976-03-11 | 1976-03-11 | Aminoglycoside antibiotic compounds and process for preparing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES456743A1 true ES456743A1 (en) | 1978-06-01 |
Family
ID=9880112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES456743A Expired ES456743A1 (en) | 1976-03-11 | 1977-03-11 | Aminoglycoside antibiotic compounds and process for preparing the same |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5937077B2 (en) |
| BE (1) | BE852142A (en) |
| CA (1) | CA1068226A (en) |
| CH (1) | CH620944A5 (en) |
| DD (1) | DD130047A5 (en) |
| DE (1) | DE2710694C2 (en) |
| ES (1) | ES456743A1 (en) |
| FR (1) | FR2343751A1 (en) |
| GB (1) | GB1549320A (en) |
| HU (1) | HU178039B (en) |
| IT (1) | IT1114756B (en) |
| NL (1) | NL7702341A (en) |
| NO (1) | NO148558C (en) |
| PL (1) | PL104557B1 (en) |
| SE (1) | SE433091B (en) |
| SU (1) | SU952109A3 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109111376B (en) * | 2018-09-18 | 2021-09-14 | 四川医立特生物医药有限公司 | 2, 5-dideoxy streptomycin derivative and application thereof |
-
1976
- 1976-03-11 GB GB9859/76A patent/GB1549320A/en not_active Expired
-
1977
- 1977-03-03 FR FR7706178A patent/FR2343751A1/en active Granted
- 1977-03-04 NL NL7702341A patent/NL7702341A/en not_active Application Discontinuation
- 1977-03-07 BE BE175514A patent/BE852142A/en not_active IP Right Cessation
- 1977-03-08 IT IT21025/77A patent/IT1114756B/en active
- 1977-03-10 SE SE7702721A patent/SE433091B/en unknown
- 1977-03-10 NO NO770852A patent/NO148558C/en unknown
- 1977-03-10 CA CA273,830A patent/CA1068226A/en not_active Expired
- 1977-03-10 CH CH305177A patent/CH620944A5/en not_active IP Right Cessation
- 1977-03-11 ES ES456743A patent/ES456743A1/en not_active Expired
- 1977-03-11 PL PL1977196605A patent/PL104557B1/en unknown
- 1977-03-11 DE DE2710694A patent/DE2710694C2/en not_active Expired
- 1977-03-11 HU HU77LA910A patent/HU178039B/en unknown
- 1977-03-11 DD DD7700197807A patent/DD130047A5/en unknown
- 1977-03-11 JP JP52027528A patent/JPS5937077B2/en not_active Expired
- 1977-03-11 SU SU772458602A patent/SU952109A3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| CA1068226A (en) | 1979-12-18 |
| GB1549320A (en) | 1979-08-01 |
| FR2343751A1 (en) | 1977-10-07 |
| PL196605A1 (en) | 1978-02-13 |
| NL7702341A (en) | 1977-09-13 |
| DD130047A5 (en) | 1978-03-01 |
| CH620944A5 (en) | 1980-12-31 |
| PL104557B1 (en) | 1979-08-31 |
| NO770852L (en) | 1977-09-13 |
| JPS5937077B2 (en) | 1984-09-07 |
| DE2710694A1 (en) | 1977-09-15 |
| JPS52142044A (en) | 1977-11-26 |
| FR2343751B1 (en) | 1981-10-16 |
| HU178039B (en) | 1982-02-28 |
| BE852142A (en) | 1977-09-07 |
| SE433091B (en) | 1984-05-07 |
| NO148558B (en) | 1983-07-25 |
| IT1114756B (en) | 1986-01-27 |
| SE7702721L (en) | 1977-09-12 |
| DE2710694C2 (en) | 1985-08-01 |
| SU952109A3 (en) | 1982-08-15 |
| NO148558C (en) | 1983-11-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19990503 |