GB1544642A - 9,11-epoxy steroids and synthesis of corticosteroids therefrom - Google Patents

9,11-epoxy steroids and synthesis of corticosteroids therefrom

Info

Publication number
GB1544642A
GB1544642A GB23169/76A GB2316976A GB1544642A GB 1544642 A GB1544642 A GB 1544642A GB 23169/76 A GB23169/76 A GB 23169/76A GB 2316976 A GB2316976 A GB 2316976A GB 1544642 A GB1544642 A GB 1544642A
Authority
GB
United Kingdom
Prior art keywords
corticosteroids
therefrom
synthesis
epoxy steroids
steroids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23169/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Priority to GB23169/76A priority Critical patent/GB1544642A/en
Priority to CA278,482A priority patent/CA1086715A/en
Priority to JP6287977A priority patent/JPS52148062A/ja
Publication of GB1544642A publication Critical patent/GB1544642A/en
Priority to JP61238159A priority patent/JPS62142197A/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB23169/76A 1976-06-04 1976-06-04 9,11-epoxy steroids and synthesis of corticosteroids therefrom Expired GB1544642A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB23169/76A GB1544642A (en) 1976-06-04 1976-06-04 9,11-epoxy steroids and synthesis of corticosteroids therefrom
CA278,482A CA1086715A (en) 1976-06-04 1977-05-16 Steroids
JP6287977A JPS52148062A (en) 1976-06-04 1977-05-31 Steroids
JP61238159A JPS62142197A (ja) 1976-06-04 1986-10-08 ステロイド類

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB23169/76A GB1544642A (en) 1976-06-04 1976-06-04 9,11-epoxy steroids and synthesis of corticosteroids therefrom

Publications (1)

Publication Number Publication Date
GB1544642A true GB1544642A (en) 1979-04-25

Family

ID=10191289

Family Applications (1)

Application Number Title Priority Date Filing Date
GB23169/76A Expired GB1544642A (en) 1976-06-04 1976-06-04 9,11-epoxy steroids and synthesis of corticosteroids therefrom

Country Status (3)

Country Link
JP (2) JPS52148062A (pt)
CA (1) CA1086715A (pt)
GB (1) GB1544642A (pt)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
CN111944002A (zh) * 2020-07-29 2020-11-17 河南利华制药有限公司 一种倍氯米松二丙酸酯中间体及制备方法
CN112851734A (zh) * 2019-11-27 2021-05-28 重庆华邦胜凯制药有限公司 一种二丙酸倍他米松的制备方法
CN113024622A (zh) * 2019-12-24 2021-06-25 天津天药药业股份有限公司 一种连续生产的甾体溴羟工艺
CN113562912A (zh) * 2021-06-28 2021-10-29 佳尔科生物科技南通有限公司 一种处理螺内酯中间体生产废水的方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101591482B1 (ko) 2008-05-28 2016-02-03 레베라겐 바이오파마 인코포레이티드 질환의 치료를 위한 ＮＦ-κＢ 의 비호르몬성 스테로이드 조절제
EP2556083A4 (en) 2010-04-05 2013-12-04 Validus Biopharma Inc NONHORMONAL STEROID MODULATORS OF NF-KAPPA-B FOR DISEASE TREATMENT
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
EP0100874A2 (de) * 1982-07-19 1984-02-22 Schering Aktiengesellschaft Neue 6,16-Dimethylkortikoide, ihre Herstellung und Verwendung
EP0100874A3 (en) * 1982-07-19 1985-04-17 Schering Aktiengesellschaft Berlin Und Bergkamen 6,16-dimethyl corticoids, their preparation and their use
US4555507A (en) * 1982-07-19 1985-11-26 Schering Aktiengesellschaft Novel 6, 16-dimethylcorticoids, their preparation and use
CN112851734A (zh) * 2019-11-27 2021-05-28 重庆华邦胜凯制药有限公司 一种二丙酸倍他米松的制备方法
CN112851734B (zh) * 2019-11-27 2024-02-06 重庆华邦胜凯制药有限公司 一种二丙酸倍他米松的制备方法
CN113024622A (zh) * 2019-12-24 2021-06-25 天津天药药业股份有限公司 一种连续生产的甾体溴羟工艺
CN111944002A (zh) * 2020-07-29 2020-11-17 河南利华制药有限公司 一种倍氯米松二丙酸酯中间体及制备方法
CN113562912A (zh) * 2021-06-28 2021-10-29 佳尔科生物科技南通有限公司 一种处理螺内酯中间体生产废水的方法

Also Published As

Publication number Publication date
JPS6244560B2 (pt) 1987-09-21
JPS52148062A (en) 1977-12-08
CA1086715A (en) 1980-09-30
JPS62142197A (ja) 1987-06-25

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930510