GB1527563A - Propionic acid derivatives - Google Patents

Propionic acid derivatives

Info

Publication number
GB1527563A
GB1527563A GB47813/76A GB4781376A GB1527563A GB 1527563 A GB1527563 A GB 1527563A GB 47813/76 A GB47813/76 A GB 47813/76A GB 4781376 A GB4781376 A GB 4781376A GB 1527563 A GB1527563 A GB 1527563A
Authority
GB
United Kingdom
Prior art keywords
propionic acid
acid
aluminium
acid derivatives
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB47813/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1527563A publication Critical patent/GB1527563A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic

Abstract

1527563 Aluminium salts of propionic acid derivatives UPJOHN CO 17 Nov 1976 [15 Dec 1965] 47813/76 Heading C2C Compounds I in which either R 1 is i-Bu and R 2 is H or R 1 is Ph and R 2 is F, x is 0 to 2 and y is 1 to 3, provided that x + y is 3, are prepared by reacting an aqueous suspension or dispersion of 2-(4-isobutylphenyl)propionic acid or 2-(2-fluoro-4-biphenylyl)propionic acid with an aqueous solution of an aluminium acid salt, in the presence of a base. Preferably, sufficient NaOH is added to an aqueous suspension of the acid to dissolve the acid and an aqueous solution of aluminium nitrate is added to the resultant solution. The products have anti-inflammatory, analgesic and anti-pyretic activities and may be included in pharmaceutical compositions.
GB47813/76A 1975-12-15 1976-11-17 Propionic acid derivatives Expired GB1527563A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64043175A 1975-12-15 1975-12-15

Publications (1)

Publication Number Publication Date
GB1527563A true GB1527563A (en) 1978-10-04

Family

ID=24568211

Family Applications (1)

Application Number Title Priority Date Filing Date
GB47813/76A Expired GB1527563A (en) 1975-12-15 1976-11-17 Propionic acid derivatives

Country Status (10)

Country Link
JP (1) JPS5273835A (en)
AU (1) AU503656B2 (en)
BE (1) BE849450A (en)
CA (1) CA1062721A (en)
DE (1) DE2652961A1 (en)
FR (1) FR2335210A1 (en)
GB (1) GB1527563A (en)
MX (1) MX4487E (en)
NL (1) NL7613426A (en)
ZA (1) ZA766709B (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0070714A1 (en) * 1981-07-20 1983-01-26 The Upjohn Company Use of ibuprofen or flurbiprofen for the manufacture of a medicament for treating respiratory disorders
EP0120587A1 (en) * 1983-02-28 1984-10-03 The Upjohn Company Crystalline ibuprofen
GB2154233A (en) * 1984-02-16 1985-09-04 Stabil Bioterapico Farmachim Aluminium salts of arylalkanoic acids and pharmaceutical compositions containing them
US4831058A (en) * 1986-10-01 1989-05-16 Boots Company Plc Therapeutic agents
US5028625A (en) * 1989-06-20 1991-07-02 American Home Products Corporation Acid addition salt of ibuprofen and meglumine
WO1998052545A1 (en) * 1997-05-22 1998-11-26 The Boots Company Plc Pharmaceutical compositions of flurbiprofen and burn-masking agent for treating sore throat
US5889057A (en) * 1995-11-22 1999-03-30 The Boots Company Plc Flurbiprofen lozenge for the treatment of sore throat
CN111892618A (en) * 2020-08-24 2020-11-06 运城鸿博化工有限公司 Hindered phenol antioxidant with novel structure and preparation method thereof

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4145440A (en) * 1977-08-18 1979-03-20 The Upjohn Company Liquid suspension of an aluminum salt of ibuprofen
US4361580A (en) * 1980-06-20 1982-11-30 The Upjohn Manufacturing Company Aluminum ibuprofen pharmaceutical suspensions
US4861797A (en) * 1987-10-15 1989-08-29 Oratech Pharmaceutical Development Corporation Liquid ibuprofen compositions and methods of making them
DE3938227C1 (en) * 1989-11-17 1991-05-02 Dolorgiet Gmbh & Co Kg, 5205 St Augustin, De Oral antiinflammatory and analgetic pharmaceutical compsn. - comprises magnesium ibuprofen dissolved in mixt. of water, propane-1,2-diol and glycerol

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE811810A (en) * 1974-03-04 1974-09-04 2-(3-phenoxy-phenyl)-propionyloxy-aluminium - mono-or di-basic salts which form aq. suspensions without objectionable taste

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0070714A1 (en) * 1981-07-20 1983-01-26 The Upjohn Company Use of ibuprofen or flurbiprofen for the manufacture of a medicament for treating respiratory disorders
EP0120587A1 (en) * 1983-02-28 1984-10-03 The Upjohn Company Crystalline ibuprofen
GB2154233A (en) * 1984-02-16 1985-09-04 Stabil Bioterapico Farmachim Aluminium salts of arylalkanoic acids and pharmaceutical compositions containing them
US4831058A (en) * 1986-10-01 1989-05-16 Boots Company Plc Therapeutic agents
US5028625A (en) * 1989-06-20 1991-07-02 American Home Products Corporation Acid addition salt of ibuprofen and meglumine
US5889057A (en) * 1995-11-22 1999-03-30 The Boots Company Plc Flurbiprofen lozenge for the treatment of sore throat
US6166083A (en) * 1995-11-22 2000-12-26 The Boots Company, Plc Suckable flurbiprofen lozenges for treatment of sore throat
WO1998052545A1 (en) * 1997-05-22 1998-11-26 The Boots Company Plc Pharmaceutical compositions of flurbiprofen and burn-masking agent for treating sore throat
CN111892618A (en) * 2020-08-24 2020-11-06 运城鸿博化工有限公司 Hindered phenol antioxidant with novel structure and preparation method thereof

Also Published As

Publication number Publication date
FR2335210A1 (en) 1977-07-15
DE2652961A1 (en) 1977-06-16
CA1062721A (en) 1979-09-18
AU1951976A (en) 1978-05-18
NL7613426A (en) 1977-06-17
MX4487E (en) 1982-05-21
ZA766709B (en) 1977-10-26
JPS5273835A (en) 1977-06-21
FR2335210B1 (en) 1980-02-29
AU503656B2 (en) 1979-09-13
BE849450A (en) 1977-06-15

Similar Documents

Publication Publication Date Title
GEP19960467B (en) Method of producing derivatives of quinoline or their pharmaceutically acceptable esters or acid-additive salts
GB1527563A (en) Propionic acid derivatives
GB1415023A (en) Thiamphenicol derivatives
GB1456627A (en) Pyridobenzodiazepinones
GB1339748A (en) Pyrimidine derivatives
GB1462036A (en) Aminoindane derivatives
GB1434805A (en) 5-phenoxy-4-amino pyrimidines
GB1448547A (en) Derivative of phenylacetic acid
GB1505900A (en) 3,4-dihydrocarbostyril derivatives
GB1508276A (en) Oxamic and dioxamic acid derivatives
GB1529251A (en) 9,10-dihydroergopeptines
GB1490169A (en) N-vinyloxyethyl-alpha-methyl-beta-phenethylamines
ES444508A1 (en) Process for the preparation of phloroglucinol
GB1160064A (en) Indole Derivatives
GB1348259A (en) Process for the preparation of 10-oxo-7,10-dihydro-1h-dioxino- 5,4-f-quinolyl-9-carboxylic acids
GB1477263A (en) Thiamindisulphidemono-orotate and process for its preparation
ES449917A1 (en) Substituted indanones
GB1437149A (en) Spiro-compounds and a process for their preparation
GB1337389A (en) Pyrimidine derivatives
GB1254085A (en) Anthranilic acid derivatives and their use in anaesthetising fish
GB1166758A (en) Phenoxyacetic Acids
GB1315564A (en) Nickel salts of phosphonic acid monoesters
GB1235953A (en) Novel pyridine derivatives, compositions containing the same, and methods of preparing the same
GB1341612A (en) Theophylline isobutyrate salts and process for the preparation thereof
GB1283810A (en) Magnesium aspartate hydrohalides

Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee