GB1521419A - Cephalosporins - Google Patents

Cephalosporins

Info

Publication number
GB1521419A
GB1521419A GB41293/76A GB4129376A GB1521419A GB 1521419 A GB1521419 A GB 1521419A GB 41293/76 A GB41293/76 A GB 41293/76A GB 4129376 A GB4129376 A GB 4129376A GB 1521419 A GB1521419 A GB 1521419A
Authority
GB
United Kingdom
Prior art keywords
formula
cephalosporins
cephalosporin
solvate
amphoteric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB41293/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/653,999 external-priority patent/US4026888A/en
Priority claimed from US05/654,314 external-priority patent/US4061862A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of GB1521419A publication Critical patent/GB1521419A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/58—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with a nitrogen atom, which is a member of a hetero ring, attached in position 7

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The novel compounds of the formula I, in which the substituents have the meaning given in Claim 1, are obtained by treating a suspension of an amphoteric cephalosporin of the formula II, or a solvate thereof, with an aldehyde of the formula R<2>-CHO. The condensation products which are obtained represent novel synthetic cephalosporins which can be used as anti-bacterial agents and also as feed additives for animals. <IMAGE>
GB41293/76A 1975-10-06 1976-10-05 Cephalosporins Expired GB1521419A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US62000575A 1975-10-06 1975-10-06
US62230675A 1975-10-10 1975-10-10
US64031775A 1975-12-12 1975-12-12
US05/653,999 US4026888A (en) 1975-10-10 1976-01-30 Certain derivatives of particular 3-thiolated cephalosporins
US05/654,314 US4061862A (en) 1975-10-06 1976-02-02 Derivatives of 7-(cyclized)phenylglycyl-3-triazolo-thio methyl cephalosporin

Publications (1)

Publication Number Publication Date
GB1521419A true GB1521419A (en) 1978-08-16

Family

ID=27542000

Family Applications (1)

Application Number Title Priority Date Filing Date
GB41293/76A Expired GB1521419A (en) 1975-10-06 1976-10-05 Cephalosporins

Country Status (17)

Country Link
JP (1) JPS6052718B2 (en)
AU (1) AU511344B2 (en)
BE (1) BE846890A (en)
CA (1) CA1113927A (en)
CH (1) CH629500A5 (en)
CY (1) CY1121A (en)
DE (1) DE2645144C2 (en)
DK (2) DK158673C (en)
FR (1) FR2326926A1 (en)
GB (1) GB1521419A (en)
HK (1) HK41281A (en)
IE (1) IE43666B1 (en)
KE (1) KE3154A (en)
LU (1) LU75935A1 (en)
NL (1) NL189670C (en)
SE (1) SE434952B (en)
YU (1) YU40287B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0003847A1 (en) * 1978-02-27 1979-09-05 Chugai Seiyaku Kabushiki Kaisha Biphenylylglycine derivatives and their salts with bases

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54112892A (en) * 1978-02-23 1979-09-04 Shionogi & Co Ltd Substituted imidazolidinyl-3-chloro-3-cephem-4-carboxylic acid
WO2019168164A1 (en) * 2018-03-02 2019-09-06 国立大学法人大阪大学 Molecule for protein and/or peptide design

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0003847A1 (en) * 1978-02-27 1979-09-05 Chugai Seiyaku Kabushiki Kaisha Biphenylylglycine derivatives and their salts with bases

Also Published As

Publication number Publication date
DK158673B (en) 1990-07-02
DK158673C (en) 1991-01-14
FR2326926A1 (en) 1977-05-06
DK200488A (en) 1988-04-12
IE43666L (en) 1977-04-06
FR2326926B1 (en) 1980-07-11
LU75935A1 (en) 1977-05-25
NL189670B (en) 1993-01-18
SE434952B (en) 1984-08-27
IE43666B1 (en) 1981-04-22
SE7610989L (en) 1977-04-07
KE3154A (en) 1981-09-18
DK200488D0 (en) 1988-04-12
YU243176A (en) 1982-06-30
YU40287B (en) 1985-12-31
CY1121A (en) 1981-12-04
JPS6052718B2 (en) 1985-11-20
CA1113927A (en) 1981-12-08
JPS5246094A (en) 1977-04-12
DK164225B (en) 1992-05-25
DK446576A (en) 1977-04-07
NL189670C (en) 1993-06-16
AU1824576A (en) 1978-04-06
NL7611026A (en) 1977-04-12
DE2645144A1 (en) 1977-04-14
CH629500A5 (en) 1982-04-30
DE2645144C2 (en) 1986-11-27
HK41281A (en) 1981-08-28
DK164225C (en) 1992-10-19
BE846890A (en) 1977-04-01
AU511344B2 (en) 1980-08-14

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Legal Events

Date Code Title Description
PS Patent sealed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19931005