GB1516414A - Prostane derivatives - Google Patents
Prostane derivativesInfo
- Publication number
- GB1516414A GB1516414A GB34969/75A GB3496975A GB1516414A GB 1516414 A GB1516414 A GB 1516414A GB 34969/75 A GB34969/75 A GB 34969/75A GB 3496975 A GB3496975 A GB 3496975A GB 1516414 A GB1516414 A GB 1516414A
- Authority
- GB
- United Kingdom
- Prior art keywords
- 3alpha
- trimethylsilyloxy
- diyl
- trimethylsilyl
- 5alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- UKVVPDHLUHAJNZ-PMACEKPBSA-N prostane Chemical class CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC UKVVPDHLUHAJNZ-PMACEKPBSA-N 0.000 title 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 3
- -1 trimethylsilyloxycarbonyl Chemical group 0.000 abstract 3
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical group C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 abstract 2
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 2
- 150000003180 prostaglandins Chemical class 0.000 abstract 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical compound F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000005529 alkyleneoxy group Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB34969/75A GB1516414A (en) | 1975-08-22 | 1975-08-22 | Prostane derivatives |
| IE1696/76A IE43930B1 (en) | 1975-08-22 | 1976-07-30 | Prostane derivatives |
| ZA764646A ZA764646B (en) | 1975-08-22 | 1976-08-02 | Prostane derivatives |
| AU16545/76A AU510107B2 (en) | 1975-08-22 | 1976-08-04 | Prostane derivatives |
| IN1390/CAL/76A IN144651B (US08088918-20120103-C00476.png) | 1975-08-22 | 1976-08-04 | |
| NO762708A NO762708L (US08088918-20120103-C00476.png) | 1975-08-22 | 1976-08-04 | |
| IL50213A IL50213A0 (en) | 1975-08-22 | 1976-08-06 | Prostane derivatives |
| US05/713,505 US4241215A (en) | 1975-08-22 | 1976-08-11 | Prostane derivatives |
| DK372376A DK372376A (da) | 1975-08-22 | 1976-08-18 | Prostanderivater |
| DE19762637384 DE2637384A1 (de) | 1975-08-22 | 1976-08-19 | Prostanderivate |
| NL7609223A NL7609223A (nl) | 1975-08-22 | 1976-08-19 | Werkwijze voor de bereiding van een prostaan derivaat. |
| CA259,466A CA1088932A (en) | 1975-08-22 | 1976-08-19 | Prostane derivatives |
| SE7609235A SE424860B (sv) | 1975-08-22 | 1976-08-19 | 4-prostenderivat till anvendning som antikonceptionellt medel, for att framkalla fodslosmertor eller for att pa tidigt stadium avbryta graviditet, eller for kontroll av den ostriska cykeln |
| BE169985A BE845404A (fr) | 1975-08-22 | 1976-08-20 | Derives du prostane |
| AR264397A AR211276A1 (es) | 1975-08-22 | 1976-08-20 | Un procendimiento para la fabricacion de derivados del acido 9 alfa 11 alfa 15-trihidroxi-4-cisprostenoico |
| DD194423A DD125481A5 (US08088918-20120103-C00476.png) | 1975-08-22 | 1976-08-20 | |
| FI762386A FI762386A (US08088918-20120103-C00476.png) | 1975-08-22 | 1976-08-20 | |
| ES450866A ES450866A1 (es) | 1975-08-22 | 1976-08-20 | Procedimiento para la preparacion de derivados de prostano. |
| FR7625397A FR2322587A1 (fr) | 1975-08-22 | 1976-08-20 | Derives du prostane |
| AT620076A AT353431B (de) | 1975-08-22 | 1976-08-20 | Verfahren zur herstellung von neuen 9alpha, 11alpha, 15-trihydroxy-4-cis-prostensaeure- derivaten und von deren salzen |
| JP51100474A JPS5225746A (en) | 1975-08-22 | 1976-08-23 | Prostane derivatives* process for manufacture thereof and pharmacological or veterinary working agents |
| ES461837A ES461837A1 (es) | 1975-08-22 | 1977-08-23 | Procedimiento para la preparacion de derivados de prostano. |
| US06/095,306 US4306095A (en) | 1975-08-22 | 1979-11-19 | Prostane derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB34969/75A GB1516414A (en) | 1975-08-22 | 1975-08-22 | Prostane derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1516414A true GB1516414A (en) | 1978-07-05 |
Family
ID=10372250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB34969/75A Expired GB1516414A (en) | 1975-08-22 | 1975-08-22 | Prostane derivatives |
Country Status (21)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1582853A (en) * | 1977-06-16 | 1981-01-14 | Ici Ltd | Prostane derivatives |
| FR2399999A1 (fr) * | 1977-08-12 | 1979-03-09 | Ici Ltd | Carbamates ou esters de derives du 4-prostene-1-ol et composition pharmaceutique ou veterinaire les contenant |
| JPS5686083A (en) * | 1979-12-13 | 1981-07-13 | Trio Kenwood Corp | Controlling device for motor |
| JPS59148588A (ja) * | 1983-02-10 | 1984-08-25 | Fuji Photo Film Co Ltd | 電動機の速度制御装置 |
| EP0944593A2 (en) | 1996-11-12 | 1999-09-29 | Alcon Laboratories, Inc. | $i(CIS)-$g(D)?4 ANALOGS OF PROSTAGLANDINS AS OCULAR HYPOTENSIVES |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2317019A1 (de) * | 1972-04-27 | 1973-11-08 | Upjohn Co | Neue 4,5-didehydro-prostaglandine |
| DD118856A5 (US08088918-20120103-C00476.png) * | 1972-11-08 | 1976-03-20 | ||
| US4032561A (en) * | 1975-05-27 | 1977-06-28 | The Upjohn Company | 17-Phenyl-18,19,20-trinor-cis-4,5-didehydro-PGF1.sub.α compounds |
-
1975
- 1975-08-22 GB GB34969/75A patent/GB1516414A/en not_active Expired
-
1976
- 1976-07-30 IE IE1696/76A patent/IE43930B1/en unknown
- 1976-08-02 ZA ZA764646A patent/ZA764646B/xx unknown
- 1976-08-04 NO NO762708A patent/NO762708L/no unknown
- 1976-08-04 IN IN1390/CAL/76A patent/IN144651B/en unknown
- 1976-08-04 AU AU16545/76A patent/AU510107B2/en not_active Expired
- 1976-08-06 IL IL50213A patent/IL50213A0/xx unknown
- 1976-08-11 US US05/713,505 patent/US4241215A/en not_active Expired - Lifetime
- 1976-08-18 DK DK372376A patent/DK372376A/da unknown
- 1976-08-19 NL NL7609223A patent/NL7609223A/xx not_active Application Discontinuation
- 1976-08-19 CA CA259,466A patent/CA1088932A/en not_active Expired
- 1976-08-19 DE DE19762637384 patent/DE2637384A1/de not_active Ceased
- 1976-08-19 SE SE7609235A patent/SE424860B/xx unknown
- 1976-08-20 FI FI762386A patent/FI762386A/fi not_active Application Discontinuation
- 1976-08-20 ES ES450866A patent/ES450866A1/es not_active Expired
- 1976-08-20 DD DD194423A patent/DD125481A5/xx unknown
- 1976-08-20 AT AT620076A patent/AT353431B/de not_active IP Right Cessation
- 1976-08-20 FR FR7625397A patent/FR2322587A1/fr active Granted
- 1976-08-20 BE BE169985A patent/BE845404A/xx unknown
- 1976-08-20 AR AR264397A patent/AR211276A1/es active
- 1976-08-23 JP JP51100474A patent/JPS5225746A/ja active Pending
-
1977
- 1977-08-23 ES ES461837A patent/ES461837A1/es not_active Expired
-
1979
- 1979-11-19 US US06/095,306 patent/US4306095A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US4306095A (en) | 1981-12-15 |
| AR211276A1 (es) | 1977-11-15 |
| IE43930L (en) | 1977-02-22 |
| CA1088932A (en) | 1980-11-04 |
| FR2322587A1 (fr) | 1977-04-01 |
| SE424860B (sv) | 1982-08-16 |
| ES450866A1 (es) | 1977-12-01 |
| DD125481A5 (US08088918-20120103-C00476.png) | 1977-04-20 |
| IE43930B1 (en) | 1981-07-01 |
| FI762386A (US08088918-20120103-C00476.png) | 1977-02-23 |
| SE7609235L (sv) | 1977-02-23 |
| NL7609223A (nl) | 1977-02-24 |
| JPS5225746A (en) | 1977-02-25 |
| AU510107B2 (en) | 1980-06-05 |
| ATA620076A (de) | 1979-04-15 |
| NO762708L (US08088918-20120103-C00476.png) | 1977-02-23 |
| BE845404A (fr) | 1977-02-21 |
| ZA764646B (en) | 1977-07-27 |
| IL50213A0 (en) | 1976-10-31 |
| DE2637384A1 (de) | 1977-03-03 |
| AT353431B (de) | 1979-11-12 |
| ES461837A1 (es) | 1978-05-16 |
| AU1654576A (en) | 1978-02-09 |
| US4241215A (en) | 1980-12-23 |
| IN144651B (US08088918-20120103-C00476.png) | 1978-06-03 |
| FR2322587B1 (US08088918-20120103-C00476.png) | 1980-03-28 |
| DK372376A (da) | 1977-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |