GB1513806A - Blood coagulation and separation - Google Patents
Blood coagulation and separationInfo
- Publication number
- GB1513806A GB1513806A GB4140775A GB4140775A GB1513806A GB 1513806 A GB1513806 A GB 1513806A GB 4140775 A GB4140775 A GB 4140775A GB 4140775 A GB4140775 A GB 4140775A GB 1513806 A GB1513806 A GB 1513806A
- Authority
- GB
- United Kingdom
- Prior art keywords
- blood
- particles
- coagulation
- heavier
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000023555 blood coagulation Effects 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- 210000004369 blood Anatomy 0.000 abstract 11
- 239000008280 blood Substances 0.000 abstract 11
- 239000002245 particle Substances 0.000 abstract 10
- 239000000203 mixture Substances 0.000 abstract 5
- 239000011521 glass Substances 0.000 abstract 4
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- 239000005995 Aluminium silicate Substances 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000013019 agitation Methods 0.000 abstract 1
- 235000012211 aluminium silicate Nutrition 0.000 abstract 1
- 239000000440 bentonite Substances 0.000 abstract 1
- 229910000278 bentonite Inorganic materials 0.000 abstract 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000005192 partition Methods 0.000 abstract 1
- 229920003023 plastic Polymers 0.000 abstract 1
- 239000004033 plastic Substances 0.000 abstract 1
- 239000013049 sediment Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Ecology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Centrifugal Separators (AREA)
Abstract
1513806 Centrifuging blood CORNING GLASS WORKS 9 Oct 1975 [7 Nov 1974] 41407/75 Heading B2P In a method of separating blood into lighter and heavier phases, a vessel is provided with a quantity of coagulation-enhancing particles of a material selected from a group of siliceous substances including glass, kaolin, bentonite, hydrated aluminium silicate and diatomaceous silica, and is supplied with blood the particles having a size and density such that they are readily suspended throughout the blood without external agitation and remain so suspended until coagulation of the blood is complete and the mixture of blood and particles is centrifuged to separate the mixture into a lighter phase consisting of serum and a heavier phase consisting of cellular and fibrillar matter and the coagulation-enhancing particles. The vessel may be in the form of a glass of plastics tube fitted with a pierceable closure through which blood may be siphoned into the tube by venipuncture with a double-ended needle. The coagulation-enhancing particles 20, Fig. 4, may be applied to the interior surface 34 of a cavity 33 within a member 32 which is initially placed in separating gel 30 positioned at the closed end of the tube. As blood is supplied to the tube the particles 20 become suspended in it and upon application of centrifugal force, are precipitated with the heavier phase toward the closed end of the vessel and away from the lighter phase which is moved toward the open end. The gel 30 is forced upwardly by the member 32 to partition the separated lighter and heavier phases. The coagulation-enhancing particles may be prepared by grinding into a finely divided powder glass having a density greater than that of the serum phase of the blood; mixing the powder with a liquid having a density not greater than that of whole blood; allowing the mixture to stand so as to sediment the heavier particles and separating the latter from the remaining mixture; centrifuging the remaining mixture under a force greater in magnitude and duration than that used in the normal centrifugation of blood to precipitate particle therefrom; and removing and drying the precipitated particles.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52174074A | 1974-11-07 | 1974-11-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1513806A true GB1513806A (en) | 1978-06-07 |
Family
ID=24077937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4140775A Expired GB1513806A (en) | 1974-11-07 | 1975-10-09 | Blood coagulation and separation |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS5169264A (en) |
| CA (1) | CA1041903A (en) |
| DE (2) | DE2545749A1 (en) |
| FR (1) | FR2290665A1 (en) |
| GB (1) | GB1513806A (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4190535A (en) * | 1978-02-27 | 1980-02-26 | Corning Glass Works | Means for separating lymphocytes and monocytes from anticoagulated blood |
| US4310430A (en) * | 1979-09-11 | 1982-01-12 | Terumo Corporation | α-Olefin-dialkylmaleate-based liquid separating agent |
| JPS5644056A (en) * | 1979-09-17 | 1981-04-23 | Sekisui Chem Co Ltd | Composition for separating serum |
| NO146616C (en) * | 1979-10-04 | 1982-11-03 | Ken Heimreid | PROCEDURE AND APPARATUS FOR PREPARATION FOR INVESTIGATION OF UNCOAGULATED BLOOD. |
| DE3029579C2 (en) * | 1980-08-05 | 1985-12-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Method and means for separating plasma or serum from whole blood |
| JPS57146162A (en) * | 1981-03-05 | 1982-09-09 | Michizo Yamano | Method for obtaining serum by filtering blood |
| JPS57159562A (en) * | 1981-03-24 | 1982-10-01 | Sekisui Chem Co Ltd | Separation of serum |
| JPS57187658A (en) * | 1981-05-13 | 1982-11-18 | Sekisui Chem Co Ltd | Container for blood inspection |
| JPS5842970A (en) * | 1981-09-07 | 1983-03-12 | Sekisui Chem Co Ltd | Receptacle for blood test |
| JPS58105064A (en) * | 1981-12-17 | 1983-06-22 | Sekisui Chem Co Ltd | Promoter for blood coagulation |
| JPS58144746A (en) * | 1982-02-23 | 1983-08-29 | Sekisui Chem Co Ltd | Separation of serum and blood clot |
| JPS58196457A (en) * | 1982-05-11 | 1983-11-15 | Sekisui Chem Co Ltd | Separation of serum from blood clot |
| DE3343887A1 (en) * | 1983-12-05 | 1985-06-13 | Walter Sarstedt Kunststoff-Spritzgußwerk, 5223 Nümbrecht | ARRANGEMENT FOR PLACING A SEPARATOR BETWEEN TWO PHASES IN A SAMPLE TUBE |
| DE3637421C1 (en) * | 1986-11-03 | 1987-10-29 | Nerbe Plus Ges Fuer Medizinisc | Reaction vessel for the blood coagulation reaction |
| US4883764A (en) * | 1987-07-20 | 1989-11-28 | Kloepfer Mary A | Blood test strip |
| US5326535A (en) * | 1993-04-30 | 1994-07-05 | Becton, Dickinson And Company | Tube having unitary blood coagulation activator and method for its preparation |
| US5378431A (en) * | 1993-06-14 | 1995-01-03 | Becton, Dickinson And Company | Dual pathway clotting enhancer for blood collection tube |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4935985B2 (en) * | 1972-02-26 | 1974-09-27 | ||
| JPS542120A (en) * | 1977-06-07 | 1979-01-09 | Ricoh Co Ltd | Brake device of focal plane shutter |
-
1975
- 1975-07-16 CA CA231,655A patent/CA1041903A/en not_active Expired
- 1975-10-09 GB GB4140775A patent/GB1513806A/en not_active Expired
- 1975-10-11 DE DE19752545749 patent/DE2545749A1/en not_active Ceased
- 1975-10-11 DE DE19752560565 patent/DE2560565C2/en not_active Expired
- 1975-11-05 JP JP13221975A patent/JPS5169264A/en active Pending
- 1975-11-06 FR FR7533951A patent/FR2290665A1/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5169264A (en) | 1976-06-15 |
| FR2290665B1 (en) | 1979-07-20 |
| FR2290665A1 (en) | 1976-06-04 |
| DE2545749A1 (en) | 1976-05-13 |
| CA1041903A (en) | 1978-11-07 |
| DE2560565C2 (en) | 1985-12-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19951008 |