GB1508210A - Benzofuran-derived amidoximes and process for preparing the same - Google Patents

Benzofuran-derived amidoximes and process for preparing the same

Info

Publication number
GB1508210A
GB1508210A GB52475/75A GB5247575A GB1508210A GB 1508210 A GB1508210 A GB 1508210A GB 52475/75 A GB52475/75 A GB 52475/75A GB 5247575 A GB5247575 A GB 5247575A GB 1508210 A GB1508210 A GB 1508210A
Authority
GB
United Kingdom
Prior art keywords
compounds
benzofuran
derived
formula
chet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB52475/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labaz SA
Original Assignee
Labaz SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz SA filed Critical Labaz SA
Priority to GB52475/75A priority Critical patent/GB1508210A/en
Priority to IE2663/76A priority patent/IE44753B1/en
Priority to NZ182809A priority patent/NZ182809A/en
Priority to ZA767241A priority patent/ZA767241B/en
Priority to US05/748,725 priority patent/US4124710A/en
Priority to NL7613753A priority patent/NL7613753A/en
Priority to AR265814A priority patent/AR212605A1/en
Priority to AU20534/76A priority patent/AU503931B2/en
Priority to FR7637622A priority patent/FR2336127A1/en
Priority to FI763604A priority patent/FI60395C/en
Priority to PT65971A priority patent/PT65971B/en
Priority to MX765235U priority patent/MX3927E/en
Priority to BE173280A priority patent/BE849430A/en
Priority to CA267,918A priority patent/CA1080723A/en
Priority to YU03093/76A priority patent/YU309376A/en
Priority to ES454421A priority patent/ES454421A1/en
Priority to CH1603476A priority patent/CH617688A5/en
Priority to DK577276A priority patent/DK577276A/en
Priority to IT7630679A priority patent/IT1123948B/en
Priority to PL1976194589A priority patent/PL102695B1/en
Priority to DE19762657902 priority patent/DE2657902A1/en
Priority to AT948476A priority patent/AT354430B/en
Priority to SU762430683A priority patent/SU598564A3/en
Priority to HU76LA901A priority patent/HU176557B/en
Priority to SE7614368A priority patent/SE429233B/en
Priority to NO76764332A priority patent/NO144794C/en
Priority to OA56023A priority patent/OA05521A/en
Priority to JP15558976A priority patent/JPS52102268A/en
Priority to DD7600196548A priority patent/DD127762A5/en
Publication of GB1508210A publication Critical patent/GB1508210A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

1508210 Benzofuran-derived amidoxines LABAZ 30 Nov 1976 [22 Dec 1975] 52475/75 Heading C2C The invention comprises compounds of formula and their pharmaceutically acceptable acid addition salts wherein R 1 is C 1-4 alkyl or Ph, A is CH 2 , CMe 2 , CHMe or CHEt; R 2 is substituted amino; X is H, Cl or MeO; and n is 2 or 3. These compounds are prepared by heating the oxadiazolones of formula in an aqueous alcohol medium, in the presence of a base. Starting materials otherwise prepared are the analogues of (I) and (II) in which H replaces (CH 2 ) n -R 2 ; and compounds of formulµ ZCHMeCO 2 R, ZCHMeCOCI, ZCHMeCONH 2 and Z-A<SP>1</SP>-CN, wherein Z is 2-ethylbenzo-3-furyl and A<SP>1</SP> is CHMe, CHEt or CMe 2 . Therapeutic compositions having cardiovascular, antihypertensive and diuretic activity comprise compounds of the above Formula (I) and are preferably administered orally.
GB52475/75A 1975-12-22 1975-12-22 Benzofuran-derived amidoximes and process for preparing the same Expired GB1508210A (en)

Priority Applications (29)

Application Number Priority Date Filing Date Title
GB52475/75A GB1508210A (en) 1975-12-22 1975-12-22 Benzofuran-derived amidoximes and process for preparing the same
IE2663/76A IE44753B1 (en) 1975-12-22 1976-12-03 Benzofuran-derived amidoximes
NZ182809A NZ182809A (en) 1975-12-22 1976-12-06 Acetamidoxmine derivatives of benzofuran and pharmaceutical compositions
ZA767241A ZA767241B (en) 1975-12-22 1976-12-06 Heterocyclic compounds and process for preparing the same
US05/748,725 US4124710A (en) 1975-12-22 1976-12-09 Acetamidoxime derivatives and use thereof
NL7613753A NL7613753A (en) 1975-12-22 1976-12-10 PROCESS FOR THE PREPARATION OF ACEETAMIDOXIME DERIVATIVES OF BENZOFURAN, AND FOR THE PREPARATION OF PREPARATIONS CONTAINING THEM.
AR265814A AR212605A1 (en) 1975-12-22 1976-12-13 PROCEDURE FOR PREPARING NEW DERIVATIVES OF BENZOFURANIL-ACETAMIDOXIMA SUBSTITUTE
AU20534/76A AU503931B2 (en) 1975-12-22 1976-12-14 Benzofuran derived amidoximes
FR7637622A FR2336127A1 (en) 1975-12-22 1976-12-14 NEW ACETAMIDOXIME DERIVATIVES, THEIR PREPARATION PROCESS AND THE THERAPEUTIC COMPOSITIONS CONTAINING THEM
FI763604A FI60395C (en) 1975-12-22 1976-12-15 FREQUENCY REQUIREMENTS FOR THE PREPARATION OF AV 2-BENZOFURANYL-N-SUBSTITUTES WITH ACETAMIDOXIMDER WITH HOEGT BLODTRYCK FOERHINDRANDE VERKAN
PT65971A PT65971B (en) 1975-12-22 1976-12-15 Process for preparing acetamidoxime derivates
MX765235U MX3927E (en) 1975-12-22 1976-12-15 PROCEDURE FOR PREPARING ACETAMIDOXIMA DERIVATIVES
BE173280A BE849430A (en) 1975-12-22 1976-12-15 NEW ACETAMIDOXIME DERIVATIVES, THEIR PREPARATION PROCESS AND THE THERAPEUTIC COMPOSITIONS CONTAINING THEM
CA267,918A CA1080723A (en) 1975-12-22 1976-12-15 Pharmaceutically active acetamidoxime derivatives
YU03093/76A YU309376A (en) 1975-12-22 1976-12-20 Process for obtaining acetamido-oxime derivatives
ES454421A ES454421A1 (en) 1975-12-22 1976-12-20 Benzofuran-derived amidoximes and process for preparing the same
CH1603476A CH617688A5 (en) 1975-12-22 1976-12-20 Process for the preparation of new acetamidoxime derivatives
DK577276A DK577276A (en) 1975-12-22 1976-12-21 HETEROCYCLIC COMPOUNDS AND MANUFACTURING METHOD
IT7630679A IT1123948B (en) 1975-12-22 1976-12-21 HETEROCYCLIC COMPOUNDS AND PROCEDURE FOR PREPARING THE SAME
PL1976194589A PL102695B1 (en) 1975-12-22 1976-12-21 METHOD OF MAKING NEW BENZOFURANOACETAMIDOXYMS
DE19762657902 DE2657902A1 (en) 1975-12-22 1976-12-21 HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS THEREOF
AT948476A AT354430B (en) 1975-12-22 1976-12-21 METHOD FOR PRODUCING NEW ACETAMIDOXIME DERIVATIVES OF BENZOFURANE AND THEIR ACID ADDITION SALTS
SU762430683A SU598564A3 (en) 1975-12-22 1976-12-21 Method of preparing benzofuran acetamideoxime derivatives or salts thereof
HU76LA901A HU176557B (en) 1975-12-22 1976-12-21 Process for producing acetamidoxime derivatives of benzofurane
SE7614368A SE429233B (en) 1975-12-22 1976-12-21 SET TO MAKE ACETAMIDOXIMO DERIVATIVES OF BENZOFURAN
NO76764332A NO144794C (en) 1975-12-22 1976-12-21 ANALOGY PROCEDURE FOR THE PREPARATION OF PHARMACOLOGICALLY ACTIVE BENZOFURAND DERIVATIVES
OA56023A OA05521A (en) 1975-12-22 1976-12-22 Process for the preparation of new acetamidoxine derivatives.
JP15558976A JPS52102268A (en) 1975-12-22 1976-12-22 Production of acetamideoxime derevatives of benzofran and antii hypertensive agent containing same as effective component*
DD7600196548A DD127762A5 (en) 1975-12-22 1976-12-22 METHOD FOR PRODUCING AZETAMIDE OXIDE DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB52475/75A GB1508210A (en) 1975-12-22 1975-12-22 Benzofuran-derived amidoximes and process for preparing the same

Publications (1)

Publication Number Publication Date
GB1508210A true GB1508210A (en) 1978-04-19

Family

ID=10464059

Family Applications (1)

Application Number Title Priority Date Filing Date
GB52475/75A Expired GB1508210A (en) 1975-12-22 1975-12-22 Benzofuran-derived amidoximes and process for preparing the same

Country Status (28)

Country Link
JP (1) JPS52102268A (en)
AR (1) AR212605A1 (en)
AT (1) AT354430B (en)
AU (1) AU503931B2 (en)
BE (1) BE849430A (en)
CA (1) CA1080723A (en)
CH (1) CH617688A5 (en)
DD (1) DD127762A5 (en)
DE (1) DE2657902A1 (en)
DK (1) DK577276A (en)
ES (1) ES454421A1 (en)
FI (1) FI60395C (en)
FR (1) FR2336127A1 (en)
GB (1) GB1508210A (en)
HU (1) HU176557B (en)
IE (1) IE44753B1 (en)
IT (1) IT1123948B (en)
MX (1) MX3927E (en)
NL (1) NL7613753A (en)
NO (1) NO144794C (en)
NZ (1) NZ182809A (en)
OA (1) OA05521A (en)
PL (1) PL102695B1 (en)
PT (1) PT65971B (en)
SE (1) SE429233B (en)
SU (1) SU598564A3 (en)
YU (1) YU309376A (en)
ZA (1) ZA767241B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018202694A1 (en) * 2017-05-03 2018-11-08 Axxam S.P.A. Heterocyclic p2x7 antagonists

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018202694A1 (en) * 2017-05-03 2018-11-08 Axxam S.P.A. Heterocyclic p2x7 antagonists
IL270275B1 (en) * 2017-05-03 2023-03-01 Axxam Spa Heterocyclic p2x7 antagonists
US11623919B2 (en) 2017-05-03 2023-04-11 Breye Therapeutics Aps Heterocyclic P2X7 antagonists
IL270275B2 (en) * 2017-05-03 2023-07-01 Axxam Spa Heterocyclic p2x7 antagonists

Also Published As

Publication number Publication date
DE2657902A1 (en) 1977-06-30
CH617688A5 (en) 1980-06-13
FI60395B (en) 1981-09-30
IE44753B1 (en) 1982-03-24
PT65971B (en) 1978-06-16
ES454421A1 (en) 1978-10-16
AT354430B (en) 1979-01-10
NO764332L (en) 1977-06-23
FI763604A (en) 1977-06-23
FR2336127A1 (en) 1977-07-22
IT1123948B (en) 1986-04-30
AU503931B2 (en) 1979-09-27
CA1080723A (en) 1980-07-01
NZ182809A (en) 1978-11-13
IE44753L (en) 1977-06-22
SE7614368L (en) 1977-06-23
MX3927E (en) 1981-09-30
FI60395C (en) 1982-01-11
NO144794B (en) 1981-08-03
SE429233B (en) 1983-08-22
JPS52102268A (en) 1977-08-27
FR2336127B1 (en) 1978-12-29
ZA767241B (en) 1977-11-30
AR212605A1 (en) 1978-08-15
BE849430A (en) 1977-06-15
HU176557B (en) 1981-03-28
ATA948476A (en) 1979-06-15
PL102695B1 (en) 1979-04-30
PT65971A (en) 1977-01-01
SU598564A3 (en) 1978-03-15
NO144794C (en) 1981-11-11
DK577276A (en) 1977-06-23
YU309376A (en) 1982-08-31
DD127762A5 (en) 1977-10-12
OA05521A (en) 1981-04-30
NL7613753A (en) 1977-06-24
AU2053476A (en) 1978-06-22

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee