IE44753L - Benzofuran derivatives - Google Patents
Benzofuran derivativesInfo
- Publication number
- IE44753L IE44753L IE762663A IE266376A IE44753L IE 44753 L IE44753 L IE 44753L IE 762663 A IE762663 A IE 762663A IE 266376 A IE266376 A IE 266376A IE 44753 L IE44753 L IE 44753L
- Authority
- IE
- Ireland
- Prior art keywords
- compounds
- formula
- chet
- chme
- cme
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
1508210 Benzofuran-derived amidoxines LABAZ 30 Nov 1976 [22 Dec 1975] 52475/75 Heading C2C The invention comprises compounds of formula and their pharmaceutically acceptable acid addition salts wherein R 1 is C 1-4 alkyl or Ph, A is CH 2 , CMe 2 , CHMe or CHEt; R 2 is substituted amino; X is H, Cl or MeO; and n is 2 or 3. These compounds are prepared by heating the oxadiazolones of formula in an aqueous alcohol medium, in the presence of a base. Starting materials otherwise prepared are the analogues of (I) and (II) in which H replaces (CH 2 ) n -R 2 ; and compounds of formulµ ZCHMeCO 2 R, ZCHMeCOCI, ZCHMeCONH 2 and Z-A<SP>1</SP>-CN, wherein Z is 2-ethylbenzo-3-furyl and A<SP>1</SP> is CHMe, CHEt or CMe 2 . Therapeutic compositions having cardiovascular, antihypertensive and diuretic activity comprise compounds of the above Formula (I) and are preferably administered orally.
[GB1508210A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB52475/75A GB1508210A (en) | 1975-12-22 | 1975-12-22 | Benzofuran-derived amidoximes and process for preparing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE44753L true IE44753L (en) | 1977-06-22 |
| IE44753B1 IE44753B1 (en) | 1982-03-24 |
Family
ID=10464059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2663/76A IE44753B1 (en) | 1975-12-22 | 1976-12-03 | Benzofuran-derived amidoximes |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS52102268A (en) |
| AR (1) | AR212605A1 (en) |
| AT (1) | AT354430B (en) |
| AU (1) | AU503931B2 (en) |
| BE (1) | BE849430A (en) |
| CA (1) | CA1080723A (en) |
| CH (1) | CH617688A5 (en) |
| DD (1) | DD127762A5 (en) |
| DE (1) | DE2657902A1 (en) |
| DK (1) | DK577276A (en) |
| ES (1) | ES454421A1 (en) |
| FI (1) | FI60395C (en) |
| FR (1) | FR2336127A1 (en) |
| GB (1) | GB1508210A (en) |
| HU (1) | HU176557B (en) |
| IE (1) | IE44753B1 (en) |
| IT (1) | IT1123948B (en) |
| MX (1) | MX3927E (en) |
| NL (1) | NL7613753A (en) |
| NO (1) | NO144794C (en) |
| NZ (1) | NZ182809A (en) |
| OA (1) | OA05521A (en) |
| PL (1) | PL102695B1 (en) |
| PT (1) | PT65971B (en) |
| SE (1) | SE429233B (en) |
| SU (1) | SU598564A3 (en) |
| YU (1) | YU309376A (en) |
| ZA (1) | ZA767241B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3398941A1 (en) * | 2017-05-03 | 2018-11-07 | AXXAM S.p.A. | Heterocyclic p2x7 antagonists |
-
1975
- 1975-12-22 GB GB52475/75A patent/GB1508210A/en not_active Expired
-
1976
- 1976-12-03 IE IE2663/76A patent/IE44753B1/en unknown
- 1976-12-06 NZ NZ182809A patent/NZ182809A/en unknown
- 1976-12-06 ZA ZA767241A patent/ZA767241B/en unknown
- 1976-12-10 NL NL7613753A patent/NL7613753A/en not_active Application Discontinuation
- 1976-12-13 AR AR265814A patent/AR212605A1/en active
- 1976-12-14 AU AU20534/76A patent/AU503931B2/en not_active Expired
- 1976-12-14 FR FR7637622A patent/FR2336127A1/en active Granted
- 1976-12-15 BE BE173280A patent/BE849430A/en not_active IP Right Cessation
- 1976-12-15 FI FI763604A patent/FI60395C/en not_active IP Right Cessation
- 1976-12-15 CA CA267,918A patent/CA1080723A/en not_active Expired
- 1976-12-15 PT PT65971A patent/PT65971B/en unknown
- 1976-12-15 MX MX765235U patent/MX3927E/en unknown
- 1976-12-20 CH CH1603476A patent/CH617688A5/en not_active IP Right Cessation
- 1976-12-20 ES ES454421A patent/ES454421A1/en not_active Expired
- 1976-12-20 YU YU03093/76A patent/YU309376A/en unknown
- 1976-12-21 NO NO76764332A patent/NO144794C/en unknown
- 1976-12-21 PL PL1976194589A patent/PL102695B1/en unknown
- 1976-12-21 DE DE19762657902 patent/DE2657902A1/en not_active Withdrawn
- 1976-12-21 SE SE7614368A patent/SE429233B/en unknown
- 1976-12-21 HU HU76LA901A patent/HU176557B/en unknown
- 1976-12-21 AT AT948476A patent/AT354430B/en not_active IP Right Cessation
- 1976-12-21 DK DK577276A patent/DK577276A/en not_active Application Discontinuation
- 1976-12-21 SU SU762430683A patent/SU598564A3/en active
- 1976-12-21 IT IT7630679A patent/IT1123948B/en active
- 1976-12-22 DD DD7600196548A patent/DD127762A5/en unknown
- 1976-12-22 OA OA56023A patent/OA05521A/en unknown
- 1976-12-22 JP JP15558976A patent/JPS52102268A/en active Pending
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