GB1505573A - Piperidine derivatives and processes for their manufactur - Google Patents
Piperidine derivatives and processes for their manufacturInfo
- Publication number
- GB1505573A GB1505573A GB32051/75A GB3205175A GB1505573A GB 1505573 A GB1505573 A GB 1505573A GB 32051/75 A GB32051/75 A GB 32051/75A GB 3205175 A GB3205175 A GB 3205175A GB 1505573 A GB1505573 A GB 1505573A
- Authority
- GB
- United Kingdom
- Prior art keywords
- piperidyl
- alkyl
- compounds
- dihydroisoquinolin
- isoindolinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003053 piperidines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 abstract 1
- -1 1- benzyl - 4 - piperidyl Chemical group 0.000 abstract 1
- YJUWDLZUHCKODN-UHFFFAOYSA-N 2-[(pyridin-4-ylamino)methyl]benzoic acid Chemical compound OC(=O)C1=CC=CC=C1CNC1=CC=NC=C1 YJUWDLZUHCKODN-UHFFFAOYSA-N 0.000 abstract 1
- CIIHUTUQILHWCS-UHFFFAOYSA-N 2-piperidin-4-yl-3h-isoindol-1-one Chemical compound C1C2=CC=CC=C2C(=O)N1C1CCNCC1 CIIHUTUQILHWCS-UHFFFAOYSA-N 0.000 abstract 1
- OCEGHWFPXMUIOP-UHFFFAOYSA-N 2-piperidin-4-ylisoindole-1,3-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCNCC1 OCEGHWFPXMUIOP-UHFFFAOYSA-N 0.000 abstract 1
- QUYRHKMETWUHBG-UHFFFAOYSA-N 2-pyridin-4-yl-3h-isoindol-1-one Chemical compound C1C2=CC=CC=C2C(=O)N1C1=CC=NC=C1 QUYRHKMETWUHBG-UHFFFAOYSA-N 0.000 abstract 1
- ZWWHJIJWPUEHHW-UHFFFAOYSA-N 3-(pyridin-2-ylamino)-3h-2-benzofuran-1-one Chemical class C12=CC=CC=C2C(=O)OC1NC1=CC=CC=N1 ZWWHJIJWPUEHHW-UHFFFAOYSA-N 0.000 abstract 1
- 101100490437 Mus musculus Acvrl1 gene Proteins 0.000 abstract 1
- 208000001871 Tachycardia Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000933 noradrenolytic effect Effects 0.000 abstract 1
- MXXWOMGUGJBKIW-YPCIICBESA-N piperine Chemical compound C=1C=C2OCOC2=CC=1/C=C/C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-YPCIICBESA-N 0.000 abstract 1
- 229940075559 piperine Drugs 0.000 abstract 1
- WVWHRXVVAYXKDE-UHFFFAOYSA-N piperine Natural products O=C(C=CC=Cc1ccc2OCOc2c1)C3CCCCN3 WVWHRXVVAYXKDE-UHFFFAOYSA-N 0.000 abstract 1
- 235000019100 piperine Nutrition 0.000 abstract 1
- 230000009090 positive inotropic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 230000006794 tachycardia Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1058374A CH605914A5 (en:Method) | 1974-07-31 | 1974-07-31 | |
| US05/533,107 US4000287A (en) | 1974-12-16 | 1974-12-16 | Isoindolinopiperidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1505573A true GB1505573A (en) | 1978-03-30 |
Family
ID=25706951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB32051/75A Expired GB1505573A (en) | 1974-07-31 | 1975-07-31 | Piperidine derivatives and processes for their manufactur |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5139676A (en:Method) |
| AT (1) | AT355022B (en:Method) |
| AU (1) | AU498555B2 (en:Method) |
| CA (1) | CA1071211A (en:Method) |
| DE (1) | DE2533567A1 (en:Method) |
| DK (1) | DK141752B (en:Method) |
| FR (1) | FR2280377A1 (en:Method) |
| GB (1) | GB1505573A (en:Method) |
| HK (1) | HK23581A (en:Method) |
| MY (1) | MY8200004A (en:Method) |
| NL (1) | NL7508589A (en:Method) |
| SE (1) | SE7507931L (en:Method) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU77856A1 (de) * | 1977-07-27 | 1979-03-26 | Ciba Geigy Ag | Verfahren zur herstellung von neuen piperidin-derivaten |
| US4304912A (en) | 1978-07-20 | 1981-12-08 | Ciba-Geigy Corporation | Piperidine derivatives |
| FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| US5567718A (en) * | 1994-08-11 | 1996-10-22 | Hoechst Marion Roussel Inc. | 2,3-dihydro-1h-isoindole derivatives and their use as serotonin reuptake inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH574954A5 (en:Method) * | 1972-08-24 | 1976-04-30 | Ciba Geigy Ag |
-
1975
- 1975-07-09 DK DK311475AA patent/DK141752B/da unknown
- 1975-07-10 SE SE7507931A patent/SE7507931L/xx unknown
- 1975-07-17 NL NL7508589A patent/NL7508589A/xx not_active Application Discontinuation
- 1975-07-26 DE DE19752533567 patent/DE2533567A1/de not_active Withdrawn
- 1975-07-29 FR FR7523618A patent/FR2280377A1/fr active Granted
- 1975-07-29 CA CA232,449A patent/CA1071211A/en not_active Expired
- 1975-07-30 AU AU83521/75A patent/AU498555B2/en not_active Expired
- 1975-07-30 AT AT590475A patent/AT355022B/de not_active IP Right Cessation
- 1975-07-31 GB GB32051/75A patent/GB1505573A/en not_active Expired
- 1975-07-31 JP JP50092657A patent/JPS5139676A/ja active Pending
-
1981
- 1981-05-28 HK HK235/81A patent/HK23581A/xx unknown
-
1982
- 1982-12-30 MY MY4/82A patent/MY8200004A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL7508589A (nl) | 1976-02-03 |
| FR2280377A1 (fr) | 1976-02-27 |
| HK23581A (en) | 1981-06-05 |
| DE2533567A1 (de) | 1976-02-19 |
| FR2280377B1 (en:Method) | 1979-10-19 |
| CA1071211A (en) | 1980-02-05 |
| AU8352175A (en) | 1977-02-03 |
| SE7507931L (sv) | 1976-02-02 |
| MY8200004A (en) | 1982-12-31 |
| DK141752B (da) | 1980-06-09 |
| AT355022B (de) | 1980-02-11 |
| AU498555B2 (en) | 1979-03-15 |
| ATA590475A (de) | 1979-07-15 |
| DK311475A (en:Method) | 1976-02-01 |
| JPS5139676A (en) | 1976-04-02 |
| DK141752C (en:Method) | 1980-11-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |