GB1502405A - Preparation of quinoline derivatives - Google Patents
Preparation of quinoline derivativesInfo
- Publication number
- GB1502405A GB1502405A GB23285/76A GB2328576A GB1502405A GB 1502405 A GB1502405 A GB 1502405A GB 23285/76 A GB23285/76 A GB 23285/76A GB 2328576 A GB2328576 A GB 2328576A GB 1502405 A GB1502405 A GB 1502405A
- Authority
- GB
- United Kingdom
- Prior art keywords
- optionally substituted
- hydrogen
- aralkyl
- nitrogen
- quinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title abstract 4
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 150000002431 hydrogen Chemical group 0.000 abstract 6
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 5
- 125000003107 substituted aryl group Chemical group 0.000 abstract 5
- -1 amino, hydroxy Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 229910052757 nitrogen Chemical group 0.000 abstract 3
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 239000005864 Sulphur Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- DJXNJVFEFSWHLY-UHFFFAOYSA-N quinoline-3-carboxylic acid Chemical class C1=CC=CC2=CC(C(=O)O)=CN=C21 DJXNJVFEFSWHLY-UHFFFAOYSA-N 0.000 abstract 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- LJDZFAPLPVPTBD-UHFFFAOYSA-N nitroformic acid Chemical compound OC(=O)[N+]([O-])=O LJDZFAPLPVPTBD-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000005017 substituted alkenyl group Chemical group 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
- 238000007079 thiolysis reaction Methods 0.000 abstract 1
- 125000004954 trialkylamino group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU75CI00001585A HU170951B (hu) | 1975-06-06 | 1975-06-06 | Novyj sposob poluchenija hinolin-3-karbonovykh kislot |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1502405A true GB1502405A (en) | 1978-03-01 |
Family
ID=10994570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB23285/76A Expired GB1502405A (en) | 1975-06-06 | 1976-06-04 | Preparation of quinoline derivatives |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS51146476A (enrdf_load_stackoverflow) |
| DK (1) | DK247976A (enrdf_load_stackoverflow) |
| ES (1) | ES448619A1 (enrdf_load_stackoverflow) |
| FI (1) | FI761583A7 (enrdf_load_stackoverflow) |
| GB (1) | GB1502405A (enrdf_load_stackoverflow) |
| HU (1) | HU170951B (enrdf_load_stackoverflow) |
| NO (1) | NO761926L (enrdf_load_stackoverflow) |
| SE (1) | SE7606308L (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855292A (en) * | 1986-02-25 | 1989-08-08 | Otsuka Pharmaceutical Company, Limited | 1-cyclopropyl-6-fluoro-8-alkyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5540616A (en) * | 1978-09-14 | 1980-03-22 | Otsuka Pharmaceut Co Ltd | Preparation of benzo-hetero-compound |
| JPS58105965A (ja) * | 1981-12-15 | 1983-06-24 | Nippon Shinyaku Co Ltd | 置換キノリンカルボン酸誘導体 |
| JPS61143364A (ja) * | 1984-12-17 | 1986-07-01 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体の製造方法 |
| JPS61143363A (ja) * | 1984-12-17 | 1986-07-01 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体の製造方法 |
| JPS6483068A (en) * | 1987-09-25 | 1989-03-28 | Otsuka Pharma Co Ltd | Production of benzo-heterocyclic compound |
| ATE223901T1 (de) * | 1994-03-01 | 2002-09-15 | Ishihara Sangyo Kaisha | Verfahren zur herstellung von 5,7 dichlor-4- hydroxychinolin |
-
1975
- 1975-06-06 HU HU75CI00001585A patent/HU170951B/hu unknown
-
1976
- 1976-06-03 SE SE7606308A patent/SE7606308L/xx not_active Application Discontinuation
- 1976-06-04 DK DK247976A patent/DK247976A/da not_active Application Discontinuation
- 1976-06-04 NO NO761926A patent/NO761926L/no unknown
- 1976-06-04 FI FI761583A patent/FI761583A7/fi not_active Application Discontinuation
- 1976-06-04 GB GB23285/76A patent/GB1502405A/en not_active Expired
- 1976-06-05 ES ES448619A patent/ES448619A1/es not_active Expired
- 1976-06-07 JP JP51065718A patent/JPS51146476A/ja active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855292A (en) * | 1986-02-25 | 1989-08-08 | Otsuka Pharmaceutical Company, Limited | 1-cyclopropyl-6-fluoro-8-alkyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives |
| US4874764A (en) * | 1986-02-25 | 1989-10-17 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
| US4880806A (en) * | 1986-02-25 | 1989-11-14 | Otsuka Pharmaceutical Company, Limited | 1-Cyclopropyl-6-fluoro-7-piperazinyl-1,4-Dihydro-4-oxo-quinoline-3-carboxylic acid derivatives |
| US4935420A (en) * | 1986-02-25 | 1990-06-19 | Otsuka Pharmaceutical Company, Ltd. | Benzoheterocyclic compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| NO761926L (enrdf_load_stackoverflow) | 1976-12-07 |
| HU170951B (hu) | 1977-10-28 |
| FI761583A7 (enrdf_load_stackoverflow) | 1976-12-07 |
| JPS51146476A (en) | 1976-12-16 |
| SE7606308L (sv) | 1976-12-07 |
| ES448619A1 (es) | 1977-07-01 |
| DK247976A (da) | 1976-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 746 | Register noted 'licences of right' (sect. 46/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |