GB1340512A - Production of esters of chromone-2-carboxylic acids - Google Patents

Production of esters of chromone-2-carboxylic acids

Info

Publication number
GB1340512A
GB1340512A GB1340512DA GB1340512A GB 1340512 A GB1340512 A GB 1340512A GB 1340512D A GB1340512D A GB 1340512DA GB 1340512 A GB1340512 A GB 1340512A
Authority
GB
United Kingdom
Prior art keywords
groups
alkyl
chain
substituted
chromone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Ltd
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Ltd filed Critical Fisons Ltd
Publication of GB1340512A publication Critical patent/GB1340512A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1340512 Esters of chromone-2-carboxylic acids FISONS Ltd 19 Jan 1971 [21 Jan 1970] 2839/70 Heading C2C An ester of a chromone-2-carboxylic acid is obtained by cyclizing a corresponding compound containing a benzene ring carrying in positions ortho to one another the substituents -OM and -COCHR<SP>1</SP>COCOOR<SP>2</SP>, wherein M represents H or alkali metal atom, R<SP>1</SP> represents H or a C 1-10 alkyl or aryl group, and R<SP>2</SP> represents an alkyl group, under acidic conditions and in the presence of at least an equimolar proportion of an alcohol R<SP>3</SP>OH, in which R<SP>3</SP> is an alkyl group other than R<SP>2</SP>. For example, the compound cyclized may have the Formula IV wherein P, Q, R and T may be the same or different and each is selected from H, C 1-10 alkyl, or corresponding substituted alkyl or corresponding unsaturated alkyl, aralkyl groups wherein the alkyl groups contain from 1 to 10 carbon atoms; mono and polybenzenoid aryl groups; nitro groups; carboxylic acid groups (including salts, esters and amides thereof); hydroxy groups; alkoxy groups containing from 1 to 10 carbon atoms; substituted alkoxy groups; aralkoxy groups; aryloxy groups; halogen atoms and acyl groups corresponding to the above alkyl or substituted alkyl groups, or an adjacent pair of P, Q, R, and T from a fused carbocyclic or heterocyclic ring; or may have the Formula (V) wherein the pair of groups A<SP>3</SP> and A<SP>4</SP> either together form a chain or a pharmaceutically acceptable derivative thereof, or form a pair of groups and -OM, and B<SP>1</SP>, B<SP>2</SP> and B<SP>3</SP> have the same significances as P, Q, R and T as defined above, and L is a linking group, for example an -OXO- chain where X is a hydrocarbon chain which may be saturated or unsaturated, branched or straight, substituted or unsubstituted, which chain may be interrupted by one or more heterocyclic or carbocyclic rings, or by one or more carbonyl groups or oxygen atoms. The products are useful for treatment of asthma, hayfever and urticaria.
GB1340512D 1970-01-21 1970-01-21 Production of esters of chromone-2-carboxylic acids Expired GB1340512A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB283970 1970-01-21

Publications (1)

Publication Number Publication Date
GB1340512A true GB1340512A (en) 1973-12-12

Family

ID=9746925

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1340512D Expired GB1340512A (en) 1970-01-21 1970-01-21 Production of esters of chromone-2-carboxylic acids

Country Status (2)

Country Link
JP (1) JPS5526140B1 (en)
GB (1) GB1340512A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002741A1 (en) * 1988-09-14 1990-03-22 Biota Scientific Management Pty Ltd. Chromone derivatives
CN108299181A (en) * 2018-01-29 2018-07-20 南阳师范学院 A kind of twin pharmaceutical compound of double o-hydroxyacetophenones and its preparation method and application

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL140730B (en) * 1963-09-27 1974-01-15 Fisons Pharmaceuticals Ltd PROCESS FOR THE PREPARATION OF SUBSTITUTED CHROMONCABONIC ACID-2-DERIVATIVES WITH AN ANAPHYLACTIC REACTION INHIBITION.
GB1144905A (en) * 1965-03-25 1969-03-12 Fisons Pharmaceuticals Ltd Substituted bis-(2-carboxy-chromonyl-oxy) derivatives and preparation and pharmaceutical compositions thereof
FR1533506A (en) * 1966-07-05 1968-07-19 Fisons Pharmaceuticals Ltd Process for the preparation of bis-chromonyl compounds

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002741A1 (en) * 1988-09-14 1990-03-22 Biota Scientific Management Pty Ltd. Chromone derivatives
CN108299181A (en) * 2018-01-29 2018-07-20 南阳师范学院 A kind of twin pharmaceutical compound of double o-hydroxyacetophenones and its preparation method and application
CN108299181B (en) * 2018-01-29 2021-04-20 南阳师范学院 Bis-o-hydroxyacetophenone twin drug compound and preparation method and application thereof

Also Published As

Publication number Publication date
JPS5526140B1 (en) 1980-07-11

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee