GB1501438A - Fused pyrimidine-4-(3h)-ones and preparation thereof - Google Patents
Fused pyrimidine-4-(3h)-ones and preparation thereofInfo
- Publication number
- GB1501438A GB1501438A GB18583/75A GB1858375A GB1501438A GB 1501438 A GB1501438 A GB 1501438A GB 18583/75 A GB18583/75 A GB 18583/75A GB 1858375 A GB1858375 A GB 1858375A GB 1501438 A GB1501438 A GB 1501438A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- prepared
- alkoxy
- alkyl
- ones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
1501438 Fused - pyrimidine - 4(3H) - ones PFIZER Inc 2 May 1975 [5 July 1974] 18583/75 Addition to 1458205 Heading C2C Novel compounds I, II and III and salts thereof in which R is Me, Et, MeCO or COR<SP>0</SP> (where R is OH, alkoxy, hydroxyalkoxy, NH 2 or NHOH); Y is H, alkyl, carbalkoxyalkyl, carboxyalkyl, -(CH 2 ) m -OCOPh or -(CH 2 ) m -OCOalkyl (where m is 2 to 4) with the proviso that when R<SP>0</SP> is NH 2 or NHOH then Y is H; R<SP>1</SP> is H, alkyl or Ph and R<SP>2</SP>, R<SP>3</SP>, R<SP>4</SP> and R<SP>5</SP> are selected from (a), H, alkyl, alkoxy, halo, benzyloxy, MeS and MeSO or (b) OH, SH, alkanoyloxy, benzoyloxy, benzylthio and benzylsulphinyl providing that at least one is selected from (b); are prepared by methods analogous to those described in the parent Specification for compounds where R is COR; compounds I (Y= H; R=Me, Et) are prepared oyclizing the appropriate 2 - amino - quinoline - 3 - carboxamide or 2-aminonicotinamide either with Ac 2 O or (EtCO) 2 O or with (EtO) 3 Me or (EtO) 3 Et in the presence of H 2 SO 4 ; compounds I (R= MeCO) are prepared by oxidation of the corresponding compound (R=Et) using SeO 2 ; compounds I where Y Is other than H are prepared by alkylation of such compounds where Y=H using an appropriate alkylating agent. Compounds where R is hydroxyalkyl are prepared by transesterification of compounds where R is alkoxy. Compounds where any one of R 2 , R 3 , R 4 or R 5 is MeSO or B 3 SO are prepared by oxidation of corresponding MeS or B 3 S compound. Compounds where R 2 , R 3 , R 4 or R 5 are B 3 O or B 3 S are debenzylated to give the corresponding OH or SH compounds and these compounds may in turn be acylated to give compounds containing an alkanoyloxy or benzyloxy substituent. Compounds I, II and III have anti-allergy activity and form with a carrier a pharmaceutical composition which may be administered orally, parenterally or by inhalation.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/485,945 US3974161A (en) | 1974-02-20 | 1974-07-05 | Fused pyrimidin-4(3H)-ones as antiallergy agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1501438A true GB1501438A (en) | 1978-02-15 |
Family
ID=23930024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB18583/75A Expired GB1501438A (en) | 1974-07-05 | 1975-05-02 | Fused pyrimidine-4-(3h)-ones and preparation thereof |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS518280A (en) |
| AR (1) | AR214389A1 (en) |
| AT (1) | AT351546B (en) |
| BE (1) | BE829987R (en) |
| BG (1) | BG25226A3 (en) |
| CA (1) | CA1053674A (en) |
| CH (1) | CH619951A5 (en) |
| DD (1) | DD118093A6 (en) |
| DE (1) | DE2525050A1 (en) |
| DK (1) | DK250275A (en) |
| ES (1) | ES437966A2 (en) |
| FI (1) | FI59097C (en) |
| GB (1) | GB1501438A (en) |
| IE (1) | IE42746B1 (en) |
| LU (1) | LU72672A1 (en) |
| NO (1) | NO751594L (en) |
| RO (1) | RO69550A (en) |
| SE (1) | SE420610B (en) |
| YU (1) | YU145675A (en) |
| ZA (1) | ZA752908B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5510892U (en) * | 1979-08-03 | 1980-01-24 | ||
| JPS5510891U (en) * | 1979-08-03 | 1980-01-24 | ||
| JPS5510896U (en) * | 1979-08-03 | 1980-01-24 | ||
| JPS5510894U (en) * | 1979-08-03 | 1980-01-24 | ||
| JPS59210071A (en) * | 1982-12-30 | 1984-11-28 | バイオメジヤ−・インコ−ポレ−テツド | Antiviral compound |
| US7482455B2 (en) * | 2002-10-16 | 2009-01-27 | Smithkline Beecham Corporation | Chemical compounds |
-
1975
- 1975-04-30 CA CA225,936A patent/CA1053674A/en not_active Expired
- 1975-05-01 IE IE980/75A patent/IE42746B1/en unknown
- 1975-05-02 GB GB18583/75A patent/GB1501438A/en not_active Expired
- 1975-05-05 NO NO751594A patent/NO751594L/no unknown
- 1975-05-06 ZA ZA00752908A patent/ZA752908B/en unknown
- 1975-05-27 ES ES437966A patent/ES437966A2/en not_active Expired
- 1975-06-03 FI FI751628A patent/FI59097C/en not_active IP Right Cessation
- 1975-06-03 DE DE19752525050 patent/DE2525050A1/en not_active Ceased
- 1975-06-04 DK DK250275A patent/DK250275A/en unknown
- 1975-06-04 BG BG7500030186A patent/BG25226A3/en unknown
- 1975-06-04 RO RO7582428A patent/RO69550A/en unknown
- 1975-06-05 YU YU01456/75A patent/YU145675A/en unknown
- 1975-06-06 DD DD186490A patent/DD118093A6/xx unknown
- 1975-06-06 JP JP50068456A patent/JPS518280A/ja active Pending
- 1975-06-06 AT AT432675A patent/AT351546B/en not_active IP Right Cessation
- 1975-06-06 LU LU72672A patent/LU72672A1/xx unknown
- 1975-06-06 CH CH730075A patent/CH619951A5/en not_active IP Right Cessation
- 1975-06-06 BE BE1006719A patent/BE829987R/en active
- 1975-06-06 AR AR259117A patent/AR214389A1/en active
- 1975-06-21 SE SE7504599A patent/SE420610B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU8095575A (en) | 1976-11-11 |
| CH619951A5 (en) | 1980-10-31 |
| DK250275A (en) | 1976-01-06 |
| SE7504599L (en) | 1976-01-07 |
| FI751628A (en) | 1976-01-06 |
| BE829987R (en) | 1975-12-08 |
| ZA752908B (en) | 1976-04-28 |
| RO69550A (en) | 1981-08-30 |
| SE420610B (en) | 1981-10-19 |
| YU145675A (en) | 1982-08-31 |
| CA1053674A (en) | 1979-05-01 |
| ATA432675A (en) | 1979-01-15 |
| IE42746B1 (en) | 1980-10-08 |
| LU72672A1 (en) | 1976-03-17 |
| NO751594L (en) | 1976-01-06 |
| DD118093A6 (en) | 1976-02-12 |
| ES437966A2 (en) | 1977-02-16 |
| AR214389A1 (en) | 1979-06-15 |
| JPS518280A (en) | 1976-01-23 |
| IE42746L (en) | 1976-01-05 |
| BG25226A3 (en) | 1978-08-10 |
| DE2525050A1 (en) | 1976-01-22 |
| AT351546B (en) | 1979-07-25 |
| FI59097B (en) | 1981-02-27 |
| FI59097C (en) | 1981-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |