GB1498025A - 3-carbamoyloxymethyl-7-8-(substituted acetamido)-3-cephem-4-carboxylic acid derivatives and methods for their preparation - Google Patents
3-carbamoyloxymethyl-7-8-(substituted acetamido)-3-cephem-4-carboxylic acid derivatives and methods for their preparationInfo
- Publication number
- GB1498025A GB1498025A GB4942374A GB4942374A GB1498025A GB 1498025 A GB1498025 A GB 1498025A GB 4942374 A GB4942374 A GB 4942374A GB 4942374 A GB4942374 A GB 4942374A GB 1498025 A GB1498025 A GB 1498025A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- reacting
- prepared
- group
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 5
- 150000002148 esters Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- -1 2-phenylethenyl Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- FCSKOFQQCWLGMV-UHFFFAOYSA-N 5-{5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl}-3-methylisoxazole Chemical compound O1N=C(C)C=C1CCCCCOC1=CC=C(C=2OCCN=2)C=C1Cl FCSKOFQQCWLGMV-UHFFFAOYSA-N 0.000 abstract 1
- 108010013043 Acetylesterase Proteins 0.000 abstract 1
- 101100234822 Caenorhabditis elegans ltd-1 gene Proteins 0.000 abstract 1
- 241000207199 Citrus Species 0.000 abstract 1
- ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical group CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 abstract 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 238000006136 alcoholysis reaction Methods 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 235000020971 citrus fruits Nutrition 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/32—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an araliphatic carboxylic acid, which is substituted on the aliphatic radical by hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4942374A GB1498025A (en) | 1975-10-01 | 1975-10-01 | 3-carbamoyloxymethyl-7-8-(substituted acetamido)-3-cephem-4-carboxylic acid derivatives and methods for their preparation |
| FR7533385A FR2290904A1 (fr) | 1975-10-01 | 1975-10-31 | Cephalosporines |
| BE161574A BE835238A (fr) | 1975-10-01 | 1975-11-04 | Cephalosporines |
| DE19752550151 DE2550151A1 (de) | 1975-10-01 | 1975-11-07 | Neue cephalosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| JP13559375A JPS5170791A (ja) | 1975-10-01 | 1975-11-11 | Sefuarosuhorinnoseiho |
| NL7513327A NL7513327A (nl) | 1975-10-01 | 1975-11-13 | Werkwijze voor het bereiden van nieuwe cefalospo- rinen. |
| US05/930,217 US4198503A (en) | 1974-11-05 | 1978-08-02 | 3-Carbamoyl substituted-7-ureido substituted cephalosporins |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4942374A GB1498025A (en) | 1975-10-01 | 1975-10-01 | 3-carbamoyloxymethyl-7-8-(substituted acetamido)-3-cephem-4-carboxylic acid derivatives and methods for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1498025A true GB1498025A (en) | 1978-01-18 |
Family
ID=10452295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4942374A Expired GB1498025A (en) | 1974-11-05 | 1975-10-01 | 3-carbamoyloxymethyl-7-8-(substituted acetamido)-3-cephem-4-carboxylic acid derivatives and methods for their preparation |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS5170791A (enrdf_load_stackoverflow) |
| BE (1) | BE835238A (enrdf_load_stackoverflow) |
| DE (1) | DE2550151A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2290904A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1498025A (enrdf_load_stackoverflow) |
| NL (1) | NL7513327A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4298605A (en) | 1978-06-22 | 1981-11-03 | Chugai Seiyaku Kabushiki Kaisha | Cephalosporin derivatives |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2362146A1 (fr) * | 1976-08-17 | 1978-03-17 | Fujisawa Pharmaceutical Co | Procede de preparation de composes d'acide 7-(n-substitue-2-phenylglycinamido)-3-substitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, a activite antibacterienne |
| GB8320520D0 (en) * | 1983-07-29 | 1983-09-01 | Glaxo Group Ltd | Chemical process |
| CN100372489C (zh) * | 2003-06-23 | 2008-03-05 | 乐金电子(天津)电器有限公司 | 真空吸尘器 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687949A (en) * | 1969-01-21 | 1972-08-29 | Bristol Myers Co | Synthetic cephalosporins |
-
1975
- 1975-10-01 GB GB4942374A patent/GB1498025A/en not_active Expired
- 1975-10-31 FR FR7533385A patent/FR2290904A1/fr active Granted
- 1975-11-04 BE BE161574A patent/BE835238A/xx unknown
- 1975-11-07 DE DE19752550151 patent/DE2550151A1/de active Pending
- 1975-11-11 JP JP13559375A patent/JPS5170791A/ja active Pending
- 1975-11-13 NL NL7513327A patent/NL7513327A/xx unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4298605A (en) | 1978-06-22 | 1981-11-03 | Chugai Seiyaku Kabushiki Kaisha | Cephalosporin derivatives |
| US4301161A (en) | 1978-06-22 | 1981-11-17 | Chugai Seiyaku Kabushiki Kaisha | Cephalosporin derivatives |
| US4328224A (en) | 1978-06-22 | 1982-05-04 | Chugai Seiyaku Kabushiki Kaisha | Cephalosporin derivatives |
| US4341776A (en) | 1978-06-22 | 1982-07-27 | Chugai Seiyaku Kabushiki Kaisha | Cephalosporin derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2550151A1 (de) | 1976-05-26 |
| FR2290904A1 (fr) | 1976-06-11 |
| BE835238A (fr) | 1976-05-04 |
| NL7513327A (nl) | 1976-05-18 |
| FR2290904B1 (enrdf_load_stackoverflow) | 1979-09-14 |
| JPS5170791A (ja) | 1976-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |