GB1497829A - 11-deoxyprostaglandins - Google Patents
11-deoxyprostaglandinsInfo
- Publication number
- GB1497829A GB1497829A GB16429/75A GB1642975A GB1497829A GB 1497829 A GB1497829 A GB 1497829A GB 16429/75 A GB16429/75 A GB 16429/75A GB 1642975 A GB1642975 A GB 1642975A GB 1497829 A GB1497829 A GB 1497829A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- enyl
- trans
- dioxaspiro
- chlorophenoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 hydroxymethylene Chemical group 0.000 abstract 10
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 2
- IOMZRUBUCCWVBH-UHFFFAOYSA-N 1-(4-chlorophenoxy)-3-(triphenyl-$l^{5}-phosphanylidene)propan-2-one Chemical compound C1=CC(Cl)=CC=C1OCC(=O)C=P(C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 IOMZRUBUCCWVBH-UHFFFAOYSA-N 0.000 abstract 1
- TVICFYIGXQRSRN-UHFFFAOYSA-N 1-chloro-3-(4-chlorophenoxy)propan-2-one Chemical compound ClCC(=O)COC1=CC=C(Cl)C=C1 TVICFYIGXQRSRN-UHFFFAOYSA-N 0.000 abstract 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- ZZVSJVZSZPERPY-UHFFFAOYSA-M [3-(4-chlorophenoxy)-2-oxopropyl]-triphenylphosphanium chloride Chemical compound [Cl-].O=C(C[P+](C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1)COC1=CC=C(C=C1)Cl ZZVSJVZSZPERPY-UHFFFAOYSA-M 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 125000005117 dialkylcarbamoyl group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 239000008016 pharmaceutical coating Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/535—Organo-phosphoranes
- C07F9/5352—Phosphoranes containing the structure P=C-
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB16429/75A GB1497829A (en) | 1975-04-21 | 1975-04-21 | 11-deoxyprostaglandins |
| FR7611566A FR2308357A1 (fr) | 1975-04-21 | 1976-04-20 | Nouveaux analogues de prostaglandines et leur preparation |
| DK177176A DK177176A (da) | 1975-04-21 | 1976-04-20 | Fremgangsmade til fremstilling af cyclopentanderivater |
| JP51044206A JPS51138652A (en) | 1975-04-21 | 1976-04-20 | New cyclopentane derivatives |
| AU13158/76A AU1315876A (en) | 1975-04-21 | 1976-04-20 | Prostaglandin analogues & pharmaceuticals |
| ZA762316A ZA762316B (en) | 1975-04-21 | 1976-04-20 | New cyclopentane derivatives |
| BE166302A BE840924A (fr) | 1975-04-21 | 1976-04-20 | Nouveaux analogues de prostaglandines et leur preparation |
| LU74796A LU74796A1 (cs) | 1975-04-21 | 1976-04-20 | |
| NL7604227A NL7604227A (nl) | 1975-04-21 | 1976-04-21 | Werkwijze voor het bereiden van een geneesmiddel met een bronchodilator- en maagzweren tegengaan- de werking alsmede voor het bereiden van nieuwe cyclopentaanderivaten. |
| DE19762617338 DE2617338A1 (de) | 1975-04-21 | 1976-04-21 | Neue cyclopentanderivate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB16429/75A GB1497829A (en) | 1975-04-21 | 1975-04-21 | 11-deoxyprostaglandins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1497829A true GB1497829A (en) | 1978-01-12 |
Family
ID=10077160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB16429/75A Expired GB1497829A (en) | 1975-04-21 | 1975-04-21 | 11-deoxyprostaglandins |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS51138652A (cs) |
| AU (1) | AU1315876A (cs) |
| BE (1) | BE840924A (cs) |
| DE (1) | DE2617338A1 (cs) |
| DK (1) | DK177176A (cs) |
| FR (1) | FR2308357A1 (cs) |
| GB (1) | GB1497829A (cs) |
| LU (1) | LU74796A1 (cs) |
| NL (1) | NL7604227A (cs) |
| ZA (1) | ZA762316B (cs) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2124489A (en) * | 1982-07-19 | 1984-02-22 | Ciba Geigy Ag | Medicinal composition containing pirprofen and cyclodextrin |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2834249A1 (de) * | 1978-08-04 | 1980-02-28 | Hoechst Ag | Neue prostaglandinderivate in der delta 2-11-desoxy-pgf tief 2 bzw. pge tief 2 -reihe |
| US20100130444A1 (en) * | 2007-07-11 | 2010-05-27 | El Mustapha Belgsir | Complexes of prostaglandin derivatives and monosubstituted, charged beta-cyclodextrins |
-
1975
- 1975-04-21 GB GB16429/75A patent/GB1497829A/en not_active Expired
-
1976
- 1976-04-20 DK DK177176A patent/DK177176A/da unknown
- 1976-04-20 ZA ZA762316A patent/ZA762316B/xx unknown
- 1976-04-20 LU LU74796A patent/LU74796A1/xx unknown
- 1976-04-20 BE BE166302A patent/BE840924A/xx unknown
- 1976-04-20 JP JP51044206A patent/JPS51138652A/ja active Pending
- 1976-04-20 AU AU13158/76A patent/AU1315876A/en not_active Expired
- 1976-04-20 FR FR7611566A patent/FR2308357A1/fr active Granted
- 1976-04-21 NL NL7604227A patent/NL7604227A/xx unknown
- 1976-04-21 DE DE19762617338 patent/DE2617338A1/de active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2124489A (en) * | 1982-07-19 | 1984-02-22 | Ciba Geigy Ag | Medicinal composition containing pirprofen and cyclodextrin |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2617338A1 (de) | 1976-11-04 |
| BE840924A (fr) | 1976-10-20 |
| NL7604227A (nl) | 1976-10-25 |
| FR2308357A1 (fr) | 1976-11-19 |
| ZA762316B (en) | 1977-04-27 |
| AU1315876A (en) | 1977-10-27 |
| FR2308357B1 (cs) | 1979-10-05 |
| JPS51138652A (en) | 1976-11-30 |
| DK177176A (da) | 1976-10-22 |
| LU74796A1 (cs) | 1977-02-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |