GB1497735A - Dioxamic acid derivatives - Google Patents

Dioxamic acid derivatives

Info

Publication number
GB1497735A
GB1497735A GB23816/75A GB2381675A GB1497735A GB 1497735 A GB1497735 A GB 1497735A GB 23816/75 A GB23816/75 A GB 23816/75A GB 2381675 A GB2381675 A GB 2381675A GB 1497735 A GB1497735 A GB 1497735A
Authority
GB
United Kingdom
Prior art keywords
formula
image
acid derivatives
outstandingly suitable
dioxamic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23816/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1497735A publication Critical patent/GB1497735A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/20—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/21—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C205/22—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring having one nitro groups bound to the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compounds of the formula I <IMAGE> in which the groups of the formula <IMAGE> are in the meta-position or para-position to one another and the substituents have the meaning given in Patent Claim 1, are prepared by reacting a compound of the formula II <IMAGE> with an alkyloxalyl halide or a dialkyl oxalate to form the corresponding dioxamic acid ester. The latter is then hydrolysed to give the corresponding free acid of the formula I or its physiologically acceptable metal salt or ammonium salt. The novel compounds of the formula I are outstandingly suitable for the treatment of allergies and all anaphylactic reactions in sensitised human subjects and are also outstandingly suitable for prophylactic treatment.
GB23816/75A 1974-06-10 1975-06-02 Dioxamic acid derivatives Expired GB1497735A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47781874A 1974-06-10 1974-06-10

Publications (1)

Publication Number Publication Date
GB1497735A true GB1497735A (en) 1978-01-12

Family

ID=23897489

Family Applications (1)

Application Number Title Priority Date Filing Date
GB23816/75A Expired GB1497735A (en) 1974-06-10 1975-06-02 Dioxamic acid derivatives

Country Status (9)

Country Link
JP (1) JPS5829779B2 (en)
BE (1) BE830069A (en)
CA (1) CA1058208A (en)
CH (1) CH614191A5 (en)
DE (1) DE2525249C2 (en)
FR (1) FR2273526A1 (en)
GB (1) GB1497735A (en)
NL (1) NL7506865A (en)
ZA (1) ZA753107B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1075092A (en) * 1976-01-19 1980-04-08 Seatek (A California Partnership) Method and apparatus for stabilization of a floating semi-submersible structure
JPS604037B2 (en) * 1978-02-10 1985-02-01 九州大学長 floating marine station
JPS5587690A (en) * 1978-12-26 1980-07-02 Mitsui Eng & Shipbuild Co Ltd Wave trap at barge integrator
JPS628894A (en) * 1985-07-08 1987-01-16 Toshio Kato Wave affection removing device
JPS62292587A (en) * 1986-06-10 1987-12-19 Sumitomo Heavy Ind Ltd Underwater floating body for semi-submerged marine structure
DE4208019A1 (en) * 1991-06-10 1992-12-24 Banning Gmbh J Blanks prodn. for rotationally symmetrical components - using ring to prevent diametral expansion of blank

Also Published As

Publication number Publication date
FR2273526A1 (en) 1976-01-02
BE830069A (en) 1975-12-10
CA1058208A (en) 1979-07-10
FR2273526B1 (en) 1978-11-10
JPS516952A (en) 1976-01-20
CH614191A5 (en) 1979-11-15
JPS5829779B2 (en) 1983-06-24
DE2525249C2 (en) 1984-04-26
DE2525249A1 (en) 1976-01-02
ZA753107B (en) 1976-04-28
AU8128975A (en) 1976-11-25
NL7506865A (en) 1975-12-12

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee