GB1495176A - Derivatives of 5h-dibenz(b,f)azepine and process for the manufacture thereof - Google Patents
Derivatives of 5h-dibenz(b,f)azepine and process for the manufacture thereofInfo
- Publication number
- GB1495176A GB1495176A GB39319/75A GB3931975A GB1495176A GB 1495176 A GB1495176 A GB 1495176A GB 39319/75 A GB39319/75 A GB 39319/75A GB 3931975 A GB3931975 A GB 3931975A GB 1495176 A GB1495176 A GB 1495176A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dibenz
- azepine
- derivatives
- manufacture
- sept
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- LCGTWRLJTMHIQZ-UHFFFAOYSA-N 5H-dibenzo[b,f]azepine Chemical class C1=CC2=CC=CC=C2NC2=CC=CC=C21 LCGTWRLJTMHIQZ-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1309574A CH605791A5 (en, 2012) | 1974-09-27 | 1974-09-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1495176A true GB1495176A (en) | 1977-12-14 |
Family
ID=4389259
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB26547/77A Expired GB1495177A (en) | 1974-09-27 | 1975-09-25 | Derivatives of 5h-dibenz(b,f)azepine and process for the manufacture thereof |
| GB39319/75A Expired GB1495176A (en) | 1974-09-27 | 1975-09-25 | Derivatives of 5h-dibenz(b,f)azepine and process for the manufacture thereof |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB26547/77A Expired GB1495177A (en) | 1974-09-27 | 1975-09-25 | Derivatives of 5h-dibenz(b,f)azepine and process for the manufacture thereof |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4076812A (en, 2012) |
| JP (1) | JPS5159887A (en, 2012) |
| AR (2) | AR207601A1 (en, 2012) |
| AT (1) | AT346339B (en, 2012) |
| AU (1) | AU504972B2 (en, 2012) |
| BE (1) | BE833852A (en, 2012) |
| CA (1) | CA1067900A (en, 2012) |
| CH (1) | CH605791A5 (en, 2012) |
| CS (2) | CS190496B2 (en, 2012) |
| DE (1) | DE2542335A1 (en, 2012) |
| DK (1) | DK395675A (en, 2012) |
| ES (1) | ES441272A1 (en, 2012) |
| FI (1) | FI59093C (en, 2012) |
| FR (2) | FR2313071A1 (en, 2012) |
| GB (2) | GB1495177A (en, 2012) |
| HU (1) | HU170395B (en, 2012) |
| IE (1) | IE41860B1 (en, 2012) |
| IL (1) | IL48182A (en, 2012) |
| NL (1) | NL7511313A (en, 2012) |
| NO (1) | NO143156C (en, 2012) |
| SE (1) | SE413771B (en, 2012) |
| ZA (1) | ZA756135B (en, 2012) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2128996A (en) * | 1982-10-15 | 1984-05-10 | Ciba Geigy Ag | 5H-dibenz[b,f]azopine-5- carboxamides |
| GB2401605A (en) * | 2003-05-12 | 2004-11-17 | Portela & Ca Sa | Method for racemisation of (S)-(+)- and (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide and optically enriched mixtures thereof |
| WO2020157257A1 (en) | 2019-02-01 | 2020-08-06 | H. Lundbeck A/S | Injectable carbamazepine composition essentially free of 10-br-carbamazepine |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0011603A1 (de) * | 1978-11-10 | 1980-05-28 | Ciba-Geigy Ag | 10-Cyan-5H-dibenz(b,f)azepin-5-carboxamid, Verfahren zu seiner Herstellung und pharmazeutische Präparate, welche diese Verbindung enthalten |
| US4431641A (en) * | 1980-10-17 | 1984-02-14 | Ciba-Geigy Corporation | Pharmaceutical compositions having antiepileptic and antineuralgic action |
| CH649080A5 (de) * | 1981-04-16 | 1985-04-30 | Ciba Geigy Ag | 5h-dibenz(b,f)azepin-5-carboxamide als mittel zur prophylaxe und behandlung von zerebraler leistungsinsuffizienz. |
| CA2079064A1 (en) * | 1991-09-24 | 1993-03-25 | Masahiro Usuki | Polymer scale preventive agent, polymerization vessel effective in preventing polymer scale deposition, and process of producing polymer using said vessel |
| US5472714A (en) * | 1993-09-08 | 1995-12-05 | Ciba-Geigy Corporation | Double-layered oxcarbazepine tablets |
| DE4421294A1 (de) * | 1994-06-17 | 1995-12-21 | Chemie Linz Deutschland | Verfahren zur Herstellung von 5H-Dibenz-(b,f)-azepin-5-carboxamid |
| US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2762796A (en) * | 1956-09-11 | Iminodibenzyl derivative | ||
| DD82719B (en, 2012) * | ||||
| BE585357A (fr) * | 1958-12-06 | 1960-06-07 | Geigy Ag J R | Nouvelles dibenzo-azepines et leur préparation. |
| ES262485A1 (es) * | 1959-11-16 | 1961-06-01 | Geigy Ag J R | Procedimiento para la preparaciën de nuevos derivados de la azepina |
-
1974
- 1974-09-27 CH CH1309574A patent/CH605791A5/xx not_active IP Right Cessation
-
1975
- 1975-01-01 AR AR260598A patent/AR207601A1/es active
- 1975-09-03 DK DK395675A patent/DK395675A/da unknown
- 1975-09-04 SE SE7509844A patent/SE413771B/xx unknown
- 1975-09-16 FI FI752579A patent/FI59093C/fi not_active IP Right Cessation
- 1975-09-19 NO NO753200A patent/NO143156C/no unknown
- 1975-09-22 US US05/615,256 patent/US4076812A/en not_active Expired - Lifetime
- 1975-09-23 DE DE19752542335 patent/DE2542335A1/de not_active Withdrawn
- 1975-09-25 IL IL48182A patent/IL48182A/xx unknown
- 1975-09-25 GB GB26547/77A patent/GB1495177A/en not_active Expired
- 1975-09-25 AU AU85173/75A patent/AU504972B2/en not_active Expired
- 1975-09-25 FR FR7529382A patent/FR2313071A1/fr active Granted
- 1975-09-25 CA CA236,329A patent/CA1067900A/en not_active Expired
- 1975-09-25 NL NL7511313A patent/NL7511313A/xx not_active Application Discontinuation
- 1975-09-25 GB GB39319/75A patent/GB1495176A/en not_active Expired
- 1975-09-25 ES ES441272A patent/ES441272A1/es not_active Expired
- 1975-09-26 ZA ZA00756135A patent/ZA756135B/xx unknown
- 1975-09-26 IE IE2105/75A patent/IE41860B1/en unknown
- 1975-09-26 HU HUCI1613A patent/HU170395B/hu unknown
- 1975-09-26 JP JP50115723A patent/JPS5159887A/ja active Pending
- 1975-09-26 BE BE160396A patent/BE833852A/xx unknown
- 1975-09-26 AT AT737675A patent/AT346339B/de not_active IP Right Cessation
- 1975-09-27 CS CS756548A patent/CS190496B2/cs unknown
- 1975-09-27 CS CS772332A patent/CS190499B2/cs unknown
-
1976
- 1976-06-16 AR AR263640A patent/AR217806A1/es active
- 1976-06-18 FR FR7618603A patent/FR2308370A1/fr active Granted
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2128996A (en) * | 1982-10-15 | 1984-05-10 | Ciba Geigy Ag | 5H-dibenz[b,f]azopine-5- carboxamides |
| GB2401605A (en) * | 2003-05-12 | 2004-11-17 | Portela & Ca Sa | Method for racemisation of (S)-(+)- and (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide and optically enriched mixtures thereof |
| US7189846B2 (en) | 2003-05-12 | 2007-03-13 | Portela & C.A., S.A. | Method for racemization of (S)-(+)- and (R)-(−)-10,11-dihydro-10-hydroxy-5h-dibenz[B,F]azepine-5-carboxamide and optically enriched mixtures thereof |
| WO2020157257A1 (en) | 2019-02-01 | 2020-08-06 | H. Lundbeck A/S | Injectable carbamazepine composition essentially free of 10-br-carbamazepine |
| US11529357B2 (en) | 2019-02-01 | 2022-12-20 | H. Lundbeck A/S | Injectable carbamazepine composition essentially free of 10-bromo-carbamazepine |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |