GB1493931A - Guanidines isothioureas and thioureas - Google Patents

Guanidines isothioureas and thioureas

Info

Publication number
GB1493931A
GB1493931A GB5596/74A GB559674A GB1493931A GB 1493931 A GB1493931 A GB 1493931A GB 5596/74 A GB5596/74 A GB 5596/74A GB 559674 A GB559674 A GB 559674A GB 1493931 A GB1493931 A GB 1493931A
Authority
GB
United Kingdom
Prior art keywords
sulphur
alkyl
feb
hydroxyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5596/74A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Priority to GB5596/74A priority Critical patent/GB1493931A/en
Priority to CA217,572A priority patent/CA1062263A/en
Priority to IE46/75A priority patent/IE40659B1/xx
Priority to ZA00750180A priority patent/ZA75180B/xx
Priority to IL46451A priority patent/IL46451A/xx
Priority to DK14475*#A priority patent/DK14475A/da
Priority to AU77463/75A priority patent/AU500729B2/en
Priority to US05/542,971 priority patent/US3968227A/en
Priority to NL7500977A priority patent/NL7500977A/xx
Priority to BE152829A priority patent/BE824923A/xx
Priority to SE7501208A priority patent/SE416050B/xx
Priority to FR7503629A priority patent/FR2260343B1/fr
Priority to DE19752504794 priority patent/DE2504794A1/de
Priority to HU75SI1453A priority patent/HU174066B/hu
Priority to LU71804A priority patent/LU71804A1/xx
Priority to PL1975177831A priority patent/PL98615B1/pl
Priority to CH142375A priority patent/CH615916A5/de
Priority to NO750391A priority patent/NO143315C/no
Priority to JP50016800A priority patent/JPS5946219B2/ja
Priority to ES434542A priority patent/ES434542A1/es
Priority to ES437587A priority patent/ES437587A1/es
Priority to US05/678,564 priority patent/US4070472A/en
Priority to US05/678,563 priority patent/US4062967A/en
Priority to US05/836,626 priority patent/US4137319A/en
Priority to US05/836,627 priority patent/US4133886A/en
Priority to US05/843,399 priority patent/USRE29761E/en
Publication of GB1493931A publication Critical patent/GB1493931A/en
Priority to US05/941,836 priority patent/US4197305A/en
Priority to US06/070,950 priority patent/US4301165A/en
Priority to US06/272,811 priority patent/US4405621A/en
Priority to US06/509,563 priority patent/US4578388A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
GB5596/74A 1974-02-07 1974-02-07 Guanidines isothioureas and thioureas Expired GB1493931A (en)

Priority Applications (30)

Application Number Priority Date Filing Date Title
GB5596/74A GB1493931A (en) 1974-02-07 1974-02-07 Guanidines isothioureas and thioureas
CA217,572A CA1062263A (en) 1974-02-07 1975-01-08 Histamine h-2 receptor antagonists
IE46/75A IE40659B1 (en) 1974-02-07 1975-01-09 Pharmacologically active compounds
ZA00750180A ZA75180B (en) 1974-02-07 1975-01-10 Pharmacologically active compounds
IL46451A IL46451A (en) 1974-02-07 1975-01-17 Di(heteroarylmethylthioalkyl guanidino thioureido isothioureidoor mainomethylamino)-alkanes
DK14475*#A DK14475A (en:Method) 1974-02-07 1975-01-20
AU77463/75A AU500729B2 (en) 1974-02-07 1975-01-20 Imidazole derivatives
US05/542,971 US3968227A (en) 1974-02-07 1975-01-22 Guanidino, thioureido and isothioureido derivatives containing imidazole groups
NL7500977A NL7500977A (nl) 1974-02-07 1975-01-28 Werkwijze voor het bereiden van tegen de werking istamine op histamine-h-2-receptoren anta- tische verbindingen.
BE152829A BE824923A (fr) 1974-02-07 1975-01-29 Nouveaux composes pharmaceutiquement actifs
SE7501208A SE416050B (sv) 1974-02-07 1975-02-04 Forfarnde for framstellning av foreningar, som er antagonister mot vissa verkningar av histamin
FR7503629A FR2260343B1 (en:Method) 1974-02-07 1975-02-05
DE19752504794 DE2504794A1 (de) 1974-02-07 1975-02-05 Alpha, omega-diamino- oder -dithioalkylenverbindungen
HU75SI1453A HU174066B (hu) 1974-02-07 1975-02-05 Sposob poluchenija geterociklicheski zamehhjonnykh proizvodnykh mocheviny
PL1975177831A PL98615B1 (pl) 1974-02-07 1975-02-06 Sposob wytwarzania amidyn z mostkiem metylenowym
LU71804A LU71804A1 (en:Method) 1974-02-07 1975-02-06
CH142375A CH615916A5 (en:Method) 1974-02-07 1975-02-06
NO750391A NO143315C (no) 1974-02-07 1975-02-06 Analogifremgangsmaate ved fremstilling av farmakologisk aktive bis-imidazol-derivater
JP50016800A JPS5946219B2 (ja) 1974-02-07 1975-02-07 複素環式化合物の製法
ES434542A ES434542A1 (es) 1974-02-07 1975-02-07 Procedimiento para preparar compuestos antagonistas de re- ceptores h-2 de histamina.
ES437587A ES437587A1 (es) 1974-02-07 1975-05-12 Procedimiento para preparar compuestos antagonistas de re- ceptores h-2 de histamina.
US05/678,564 US4070472A (en) 1974-02-07 1976-04-20 Guanidino, thioureido, isothioureido and nitrovinylamino derivatives of pyridine
US05/678,563 US4062967A (en) 1974-02-07 1976-04-20 Bis-guanidino-alkane compounds
US05/836,626 US4137319A (en) 1974-02-07 1977-09-26 Guanidino, thioureido, isothioureido and nitrovinylamino derivatives of pyridine
US05/836,627 US4133886A (en) 1974-02-07 1977-09-26 Guanidino, thioureido, isothioureido and nitrovinylamino derivatives of pyridine
US05/843,399 USRE29761E (en) 1974-02-07 1977-10-19 Guanidino, thioureido and isothioureido derivatives containing imidazole groups
US05/941,836 US4197305A (en) 1974-02-07 1978-09-11 Thiazole, isothiazole, oxazole and isoxazole compounds
US06/070,950 US4301165A (en) 1974-02-07 1979-08-30 Pharmacologically active compounds
US06/272,811 US4405621A (en) 1974-02-07 1981-06-11 Heterocyclic thioureas, isothioureas, guanidines and nitromethylene-amidines
US06/509,563 US4578388A (en) 1974-02-07 1983-06-30 Unsymmetrical guanidino, thioureido, isothioureido and nitromethyleneamino derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5596/74A GB1493931A (en) 1974-02-07 1974-02-07 Guanidines isothioureas and thioureas

Publications (1)

Publication Number Publication Date
GB1493931A true GB1493931A (en) 1977-11-30

Family

ID=9799081

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5596/74A Expired GB1493931A (en) 1974-02-07 1974-02-07 Guanidines isothioureas and thioureas

Country Status (20)

Country Link
US (3) US3968227A (en:Method)
JP (1) JPS5946219B2 (en:Method)
AU (1) AU500729B2 (en:Method)
BE (1) BE824923A (en:Method)
CA (1) CA1062263A (en:Method)
CH (1) CH615916A5 (en:Method)
DE (1) DE2504794A1 (en:Method)
DK (1) DK14475A (en:Method)
ES (2) ES434542A1 (en:Method)
FR (1) FR2260343B1 (en:Method)
GB (1) GB1493931A (en:Method)
HU (1) HU174066B (en:Method)
IE (1) IE40659B1 (en:Method)
IL (1) IL46451A (en:Method)
LU (1) LU71804A1 (en:Method)
NL (1) NL7500977A (en:Method)
NO (1) NO143315C (en:Method)
PL (1) PL98615B1 (en:Method)
SE (1) SE416050B (en:Method)
ZA (1) ZA75180B (en:Method)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4165378A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
US4165377A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidino imidazoles and thiazoles
US4264614A (en) 1978-11-16 1981-04-28 Glaxo Group Limited Amine derivatives
US4309435A (en) 1978-10-16 1982-01-05 Imperial Chemical Industries Ltd. Antisecretory guanidine derivatives and pharmaceutical compositions containing them
US4342765A (en) 1979-01-18 1982-08-03 Imperial Chemical Industries Limited Guanidine derivatives and pharmaceutical compositions containing them

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4197305A (en) * 1974-02-07 1980-04-08 Smith Kline & French Laboratories Limited Thiazole, isothiazole, oxazole and isoxazole compounds
GB1493931A (en) * 1974-02-07 1977-11-30 Smith Kline French Lab Guanidines isothioureas and thioureas
IL49528A (en) * 1975-05-21 1980-11-30 Smith Kline French Lab Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
US4105770A (en) * 1975-07-31 1978-08-08 Smith Kline & French Laboratories Limited Heterocyclomethylsulphinylethyl derivatives of N-cyanoguanidines, thioureas and 2-amino-1-nitroethylene
ZA774220B (en) * 1976-07-28 1978-06-28 Smith Kline French Lab Pharmacologically active compounds
ZA774221B (en) * 1976-07-28 1978-06-28 Smith Kline French Lab Pharmacologically active compounds
US4210652A (en) * 1976-07-28 1980-07-01 Smith Kline & French Laboratories Limited Pharmacologically active 1,3-bis[1-(2-heteroalkylthio)ethylamino)-2-nitrovinyl-1-amino]propane derivatives
US4219553A (en) * 1976-07-28 1980-08-26 Smith Kline & French Laboratories Limited Alkoxy pyridyl substituted alkanes
US4200760A (en) * 1978-09-26 1980-04-29 Bristol-Myers Company Imidazolylalkylthioalkylamino-ethylene derivatives
JPS57102852A (en) * 1980-12-19 1982-06-26 Shionogi & Co Ltd Dicarboxylic acid diamide
CA2927544A1 (en) 2015-04-24 2016-10-24 Wal-Mart Stores, Inc. Method and apparatus for holding containers open
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB850483A (en) * 1957-10-25 1960-10-05 May & Baker Ltd Improvements in or relating to pyrimidine derivatives
US3622596A (en) * 1960-10-14 1971-11-23 A Wander Sa Dr Carbanilide compounds
DE1214239B (de) * 1960-11-01 1966-04-14 Spofa Sdruzeni Podnikuu Pro Zd Verfahren zur Herstellung von 5-bis-(beta-Chloraethyl)-aminomethyluracil-hydrochlorid
CH405282A (de) * 1961-11-24 1966-01-15 Wander Ag Dr A Verfahren zur Herstellung basischer Verbindungen
US3225047A (en) * 1964-02-24 1965-12-21 Bristol Myers Co N,n'-bis(pyrimidine-5-acetyl)ethylene diamines
CH440252A (de) * 1964-04-24 1967-07-31 Wander Ag Dr A Verfahren zur Herstellung neuer Harnstoffderivate
US3335142A (en) * 1965-07-07 1967-08-08 American Cyanamid Co Process for the preparation of n, n'-disubstituted ureas
US3646049A (en) * 1970-03-05 1972-02-29 Merck & Co Inc Acylaminobenzimidazole derivatives
US4137234A (en) * 1971-03-09 1979-01-30 Smith Kline & French Laboratories Limited Thiazole, isothiazole, oxazole and isoxazole substituted thiourea and urea compounds
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
US3917626A (en) * 1971-03-29 1975-11-04 Ici Ltd 3,6-Dioxa-1,8-octandiamido bis (pyridinium) compounds
GB1339764A (en) * 1971-03-29 1973-12-05 Ici Ltd Pyridine derivatives
GB1493931A (en) * 1974-02-07 1977-11-30 Smith Kline French Lab Guanidines isothioureas and thioureas
US4062967A (en) * 1974-02-07 1977-12-13 Smith Kline & French Laboratories Limited Bis-guanidino-alkane compounds
US4137319A (en) * 1974-02-07 1979-01-30 Smith Kline & French Laboratories Limited Guanidino, thioureido, isothioureido and nitrovinylamino derivatives of pyridine
GB1497260A (en) * 1974-06-28 1978-01-05 Smith Kline French Lab Guanidine derivatives
US4151289A (en) * 1975-01-22 1979-04-24 Smith Kline & French Laboratories Limited Nitromethylene amidino derivatives containing imidazole groups

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4165378A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
US4165377A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidino imidazoles and thiazoles
US4234735A (en) 1977-04-20 1980-11-18 Imperial Chemical Industries Limited Guanidino imidazoles and thiazoles
US4262126A (en) 1977-04-20 1981-04-14 Imperial Chemical Industries Limited Guanidine derivatives of imidazoles and thiazoles
US4309435A (en) 1978-10-16 1982-01-05 Imperial Chemical Industries Ltd. Antisecretory guanidine derivatives and pharmaceutical compositions containing them
US4264614A (en) 1978-11-16 1981-04-28 Glaxo Group Limited Amine derivatives
US4342765A (en) 1979-01-18 1982-08-03 Imperial Chemical Industries Limited Guanidine derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
NO750391L (en:Method) 1975-09-01
NL7500977A (nl) 1975-08-11
PL98615B1 (pl) 1978-05-31
JPS50108259A (en:Method) 1975-08-26
IL46451A0 (en) 1975-04-25
ZA75180B (en) 1976-01-28
US4578388A (en) 1986-03-25
IE40659B1 (en) 1979-07-18
DK14475A (en:Method) 1975-10-13
IE40659L (en) 1975-08-07
FR2260343B1 (en:Method) 1978-07-21
SE7501208L (en:Method) 1975-08-08
BE824923A (fr) 1975-07-29
ES434542A1 (es) 1976-12-16
DE2504794A1 (de) 1975-08-14
SE416050B (sv) 1980-11-24
US3968227A (en) 1976-07-06
ES437587A1 (es) 1977-01-16
HU174066B (hu) 1979-10-28
NO143315C (no) 1981-01-14
AU7746375A (en) 1976-07-22
US4301165A (en) 1981-11-17
NO143315B (no) 1980-10-06
LU71804A1 (en:Method) 1975-06-24
AU500729B2 (en) 1979-05-31
FR2260343A1 (en:Method) 1975-09-05
CH615916A5 (en:Method) 1980-02-29
CA1062263A (en) 1979-09-11
JPS5946219B2 (ja) 1984-11-10
IL46451A (en) 1980-03-31

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee