GB1490507A - Piperazine derivatives - Google Patents
Piperazine derivativesInfo
- Publication number
- GB1490507A GB1490507A GB1392376A GB1392376A GB1490507A GB 1490507 A GB1490507 A GB 1490507A GB 1392376 A GB1392376 A GB 1392376A GB 1392376 A GB1392376 A GB 1392376A GB 1490507 A GB1490507 A GB 1490507A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hal
- april
- piperazine derivatives
- novel compounds
- hypocholesterolaemic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000004885 piperazines Chemical class 0.000 title abstract 2
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000000871 hypocholesterolemic effect Effects 0.000 abstract 1
- 150000002466 imines Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7510729A FR2306694A1 (fr) | 1975-04-07 | 1975-04-07 | Derives de la piperazine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1490507A true GB1490507A (en) | 1977-11-02 |
Family
ID=9153579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1392376A Expired GB1490507A (en) | 1975-04-07 | 1976-04-06 | Piperazine derivatives |
Country Status (10)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0015615A1 (en) * | 1979-03-01 | 1980-09-17 | Duphar International Research B.V | Phenyl piperazine derivatives, their preparation and antiagressive medicines containing them |
| EP0103357A3 (en) * | 1982-06-22 | 1986-01-08 | Warner-Lambert Company | Substituted phenylpiperazine compounds suitable as antihypertensive agents, and processes for their production |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4457931A (en) * | 1982-09-27 | 1984-07-03 | Selvi & C. S.P.A. | Piperazine derivatives with anticholinergic and/or antihistaminic activity |
| BR0307429A (pt) * | 2002-02-05 | 2004-12-28 | Novo Nordisk As | Composto, uso do mesmo, composição farmacêutica, e, método para o tratamento de distúrbios ou doenças relacionadas com receptor de histamina h3 |
| EP1902028A2 (en) | 2005-07-04 | 2008-03-26 | Novo Nordisk A/S | Histamine h3 receptor antagonists |
| CA2653062A1 (en) | 2006-05-23 | 2007-11-29 | Transtech Pharma, Inc. | 6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ' ] -bipyridine and its use as a medicament |
| PL2079732T3 (pl) | 2006-05-29 | 2012-05-31 | High Point Pharmaceuticals Llc | 3-(1,3-benzodioksol-5-ylo)-6-(4-cyklopropylopiperazyn-1-ylo)-pirydazyna, jej sole i solwaty oraz jej zastosowanie jako antagonisty receptora histaminowego h3 |
| EP2014656A3 (en) | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | New heteocyclic h3 antagonists |
-
1975
- 1975-04-07 FR FR7510729A patent/FR2306694A1/fr active Granted
-
1976
- 1976-03-09 DE DE19762609746 patent/DE2609746A1/de active Pending
- 1976-03-23 DK DK125476A patent/DK140142B/da not_active IP Right Cessation
- 1976-03-29 JP JP51035056A patent/JPS51118780A/ja active Pending
- 1976-04-01 ES ES446598A patent/ES446598A1/es not_active Expired
- 1976-04-02 BE BE165796A patent/BE840326A/xx unknown
- 1976-04-05 LU LU74701A patent/LU74701A1/xx unknown
- 1976-04-05 NL NL7603508A patent/NL7603508A/xx not_active Application Discontinuation
- 1976-04-06 GB GB1392376A patent/GB1490507A/en not_active Expired
- 1976-04-06 IE IE72076A patent/IE43222B1/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0015615A1 (en) * | 1979-03-01 | 1980-09-17 | Duphar International Research B.V | Phenyl piperazine derivatives, their preparation and antiagressive medicines containing them |
| EP0103357A3 (en) * | 1982-06-22 | 1986-01-08 | Warner-Lambert Company | Substituted phenylpiperazine compounds suitable as antihypertensive agents, and processes for their production |
Also Published As
| Publication number | Publication date |
|---|---|
| IE43222B1 (en) | 1981-01-14 |
| JPS51118780A (en) | 1976-10-18 |
| ES446598A1 (es) | 1977-06-16 |
| LU74701A1 (enrdf_load_stackoverflow) | 1976-11-11 |
| DK140142B (da) | 1979-06-25 |
| BE840326A (fr) | 1976-10-04 |
| NL7603508A (nl) | 1976-10-11 |
| DK125476A (enrdf_load_stackoverflow) | 1976-10-08 |
| DE2609746A1 (de) | 1976-10-14 |
| IE43222L (en) | 1976-10-07 |
| DK140142C (enrdf_load_stackoverflow) | 1979-11-19 |
| FR2306694A1 (fr) | 1976-11-05 |
| FR2306694B1 (enrdf_load_stackoverflow) | 1980-01-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |