GB1487768A - Method of preparing a stable enzyme-hormone complex from the small intestine and therapeutic uses of said complex - Google Patents
Method of preparing a stable enzyme-hormone complex from the small intestine and therapeutic uses of said complexInfo
- Publication number
- GB1487768A GB1487768A GB51853/74A GB5185374A GB1487768A GB 1487768 A GB1487768 A GB 1487768A GB 51853/74 A GB51853/74 A GB 51853/74A GB 5185374 A GB5185374 A GB 5185374A GB 1487768 A GB1487768 A GB 1487768A
- Authority
- GB
- United Kingdom
- Prior art keywords
- small intestine
- complex
- cholic
- acid
- acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000000813 small intestine Anatomy 0.000 title abstract 5
- 229940088597 hormone Drugs 0.000 title abstract 4
- 239000005556 hormone Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 235000019416 cholic acid Nutrition 0.000 abstract 4
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 3
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 abstract 3
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 abstract 2
- 239000004380 Cholic acid Substances 0.000 abstract 2
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 abstract 2
- 229960002471 cholic acid Drugs 0.000 abstract 2
- 239000002812 cholic acid derivative Substances 0.000 abstract 2
- 150000001842 cholic acids Chemical class 0.000 abstract 2
- 238000000605 extraction Methods 0.000 abstract 2
- 102000004400 Aminopeptidases Human genes 0.000 abstract 1
- 108090000915 Aminopeptidases Proteins 0.000 abstract 1
- 108010010737 Ceruletide Proteins 0.000 abstract 1
- 101800001982 Cholecystokinin Proteins 0.000 abstract 1
- 102100025841 Cholecystokinin Human genes 0.000 abstract 1
- 102100029727 Enteropeptidase Human genes 0.000 abstract 1
- 108010013369 Enteropeptidase Proteins 0.000 abstract 1
- 108010007979 Glycocholic Acid Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- RFDAIACWWDREDC-UHFFFAOYSA-N Na salt-Glycocholic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCC(O)=O)C)C1(C)C(O)C2 RFDAIACWWDREDC-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 108010086019 Secretin Proteins 0.000 abstract 1
- 102100037505 Secretin Human genes 0.000 abstract 1
- 241000282887 Suidae Species 0.000 abstract 1
- WBWWGRHZICKQGZ-UHFFFAOYSA-N Taurocholic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCCS(O)(=O)=O)C)C1(C)C(O)C2 WBWWGRHZICKQGZ-UHFFFAOYSA-N 0.000 abstract 1
- 102000004357 Transferases Human genes 0.000 abstract 1
- 108090000992 Transferases Proteins 0.000 abstract 1
- 102000016679 alpha-Glucosidases Human genes 0.000 abstract 1
- 108010028144 alpha-Glucosidases Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000003613 bile acid Substances 0.000 abstract 1
- 244000309464 bull Species 0.000 abstract 1
- 229930190815 caerulein Natural products 0.000 abstract 1
- YRALAIOMGQZKOW-HYAOXDFASA-N ceruletide Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)[C@@H](C)O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(OS(O)(=O)=O)C=C1 YRALAIOMGQZKOW-HYAOXDFASA-N 0.000 abstract 1
- 229960001706 ceruletide Drugs 0.000 abstract 1
- 229940107137 cholecystokinin Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 abstract 1
- 229960003964 deoxycholic acid Drugs 0.000 abstract 1
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical compound C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 abstract 1
- 108010062619 enterogastrone Proteins 0.000 abstract 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 abstract 1
- RFDAIACWWDREDC-FRVQLJSFSA-N glycocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 RFDAIACWWDREDC-FRVQLJSFSA-N 0.000 abstract 1
- 229940099347 glycocholic acid Drugs 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229960002101 secretin Drugs 0.000 abstract 1
- OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 abstract 1
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 abstract 1
- YRALAIOMGQZKOW-UHFFFAOYSA-N sulfated caerulein Natural products C=1C=CC=CC=1CC(C(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CCSC)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(C(C)O)NC(=O)C(NC(=O)C(CC(O)=O)NC(=O)C(CCC(N)=O)NC(=O)C1NC(=O)CC1)CC1=CC=C(OS(O)(=O)=O)C=C1 YRALAIOMGQZKOW-UHFFFAOYSA-N 0.000 abstract 1
- WBWWGRHZICKQGZ-GIHLXUJPSA-N taurocholic acid Chemical compound C([C@@H]1C[C@H]2O)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@H](O)C1 WBWWGRHZICKQGZ-GIHLXUJPSA-N 0.000 abstract 1
- -1 tetramethylbutyl Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/595—Gastrins; Cholecystokinins [CCK]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/645—Secretins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/814—Enzyme separation or purification
- Y10S435/816—Enzyme separation or purification by solubility
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB51853/74A GB1487768A (en) | 1974-11-29 | 1974-11-29 | Method of preparing a stable enzyme-hormone complex from the small intestine and therapeutic uses of said complex |
| BE161294A BE834917A (fr) | 1974-11-29 | 1975-10-27 | Procede de preparation d'un complexe enzymatique et hormonal stable et partir de l'intestin grele, et application therapeutique du complexe |
| DE19752548175 DE2548175A1 (de) | 1974-11-29 | 1975-10-28 | Verfahren zur herstellung eines stabilen enzym- und hormonkomplexes |
| MC751168A MC1078A1 (fr) | 1974-11-29 | 1975-10-29 | Procede de preparation d'un complexe enzymatique et hormonal stable a partir de l'intestin grele |
| NO753680A NO142105C (no) | 1974-11-29 | 1975-11-03 | Fremgangsmaate til fremstilling av et stabilt enzym- og hormonkompleks fra tynntarmer |
| LU73708A LU73708A1 (en, 2012) | 1974-11-29 | 1975-11-03 | |
| ZA00756896A ZA756896B (en) | 1974-11-29 | 1975-11-03 | Method of preparing a stable enzymehormone complex from the small intestine and therapeutic uses of said complex |
| DK495575AA DK138477B (da) | 1974-11-29 | 1975-11-04 | Fremgangsmåde til fremstilling af et stabilt, enzymatisk og hormonalt kompleks ved ekstraktion af tyndtarmen fra dyr, såsom svin og okser. |
| AT841875A AT340041B (de) | 1974-11-29 | 1975-11-05 | Verfahren zur herstellung eines stabilen enzym- und hormonkomplexes |
| SE7512475A SE7512475L (sv) | 1974-11-29 | 1975-11-06 | Sett att framstella en stabil, enzymatisk och hormonell komplexforening |
| CA239,303A CA1049942A (en) | 1974-11-29 | 1975-11-10 | Enzyme-hormone complex from small intestine |
| US05/630,763 US4048303A (en) | 1974-11-29 | 1975-11-11 | Method of preparing enzyme cholic acids complex |
| FR7534435A FR2292484A1 (fr) | 1974-11-29 | 1975-11-12 | Procede de preparation d'un complexe enzymatique et hormonal stable a partir de l'intestin grele, et application therapeutique du complexe |
| ES442617A ES442617A1 (es) | 1974-11-29 | 1975-11-14 | Un procedimiento de preparacion de un complejo enzimatico. |
| NL7513529A NL7513529A (nl) | 1974-11-29 | 1975-11-19 | Werkwijze ter bereiding van een stabiel enzym- en hormooncomplex uit de dunne darm. |
| IE2581/75A IE43074B1 (en) | 1974-11-29 | 1975-11-27 | Method of preparing a stable enzyme-hormone complex from the small intestine and therapeutic uses of said complex |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB51853/74A GB1487768A (en) | 1974-11-29 | 1974-11-29 | Method of preparing a stable enzyme-hormone complex from the small intestine and therapeutic uses of said complex |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1487768A true GB1487768A (en) | 1977-10-05 |
Family
ID=10461645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB51853/74A Expired GB1487768A (en) | 1974-11-29 | 1974-11-29 | Method of preparing a stable enzyme-hormone complex from the small intestine and therapeutic uses of said complex |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4048303A (en, 2012) |
| AT (1) | AT340041B (en, 2012) |
| BE (1) | BE834917A (en, 2012) |
| CA (1) | CA1049942A (en, 2012) |
| DE (1) | DE2548175A1 (en, 2012) |
| DK (1) | DK138477B (en, 2012) |
| ES (1) | ES442617A1 (en, 2012) |
| FR (1) | FR2292484A1 (en, 2012) |
| GB (1) | GB1487768A (en, 2012) |
| IE (1) | IE43074B1 (en, 2012) |
| LU (1) | LU73708A1 (en, 2012) |
| MC (1) | MC1078A1 (en, 2012) |
| NL (1) | NL7513529A (en, 2012) |
| NO (1) | NO142105C (en, 2012) |
| SE (1) | SE7512475L (en, 2012) |
| ZA (1) | ZA756896B (en, 2012) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2144826C1 (ru) * | 1998-01-16 | 2000-01-27 | Гладских Лариса Валентиновна | Способ получения тканевого препарата для лечения заболеваний желудочно-кишечного тракта |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB561333A (en) | 1942-06-30 | 1944-05-16 | Basil Duperier Thornley | Extraction of an enzyme substance |
-
1974
- 1974-11-29 GB GB51853/74A patent/GB1487768A/en not_active Expired
-
1975
- 1975-10-27 BE BE161294A patent/BE834917A/xx unknown
- 1975-10-28 DE DE19752548175 patent/DE2548175A1/de not_active Withdrawn
- 1975-10-29 MC MC751168A patent/MC1078A1/xx unknown
- 1975-11-03 NO NO753680A patent/NO142105C/no unknown
- 1975-11-03 ZA ZA00756896A patent/ZA756896B/xx unknown
- 1975-11-03 LU LU73708A patent/LU73708A1/xx unknown
- 1975-11-04 DK DK495575AA patent/DK138477B/da unknown
- 1975-11-05 AT AT841875A patent/AT340041B/de not_active IP Right Cessation
- 1975-11-06 SE SE7512475A patent/SE7512475L/xx unknown
- 1975-11-10 CA CA239,303A patent/CA1049942A/en not_active Expired
- 1975-11-11 US US05/630,763 patent/US4048303A/en not_active Expired - Lifetime
- 1975-11-12 FR FR7534435A patent/FR2292484A1/fr active Granted
- 1975-11-14 ES ES442617A patent/ES442617A1/es not_active Expired
- 1975-11-19 NL NL7513529A patent/NL7513529A/xx not_active Application Discontinuation
- 1975-11-27 IE IE2581/75A patent/IE43074B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2292484A1 (fr) | 1976-06-25 |
| US4048303A (en) | 1977-09-13 |
| NO142105C (no) | 1980-07-02 |
| CA1049942A (en) | 1979-03-06 |
| NL7513529A (nl) | 1976-06-01 |
| DK495575A (en, 2012) | 1976-05-30 |
| SE7512475L (sv) | 1976-05-31 |
| MC1078A1 (fr) | 1976-08-06 |
| DK138477B (da) | 1978-09-18 |
| ATA841875A (de) | 1977-03-15 |
| BE834917A (fr) | 1976-04-27 |
| DE2548175A1 (de) | 1976-08-12 |
| ZA756896B (en) | 1976-10-27 |
| IE43074B1 (en) | 1980-12-17 |
| LU73708A1 (en, 2012) | 1977-06-03 |
| DK138477C (en, 2012) | 1979-02-19 |
| ES442617A1 (es) | 1977-04-16 |
| NO753680L (en, 2012) | 1976-06-01 |
| IE43074L (en) | 1976-05-29 |
| AT340041B (de) | 1977-11-25 |
| NO142105B (no) | 1980-03-24 |
| FR2292484B1 (en, 2012) | 1980-05-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |