GB1479141A - Extraction of n-blocked amino acid from aqueous solutions - Google Patents

Extraction of n-blocked amino acid from aqueous solutions

Info

Publication number
GB1479141A
GB1479141A GB36498/73A GB3649873A GB1479141A GB 1479141 A GB1479141 A GB 1479141A GB 36498/73 A GB36498/73 A GB 36498/73A GB 3649873 A GB3649873 A GB 3649873A GB 1479141 A GB1479141 A GB 1479141A
Authority
GB
United Kingdom
Prior art keywords
blocked
amino acid
aqueous solutions
ester
blocked amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB36498/73A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB36498/73A priority Critical patent/GB1479141A/en
Priority to ES428799A priority patent/ES428799A1/en
Priority to IE1625/74A priority patent/IE39650B1/en
Priority to DE2436772A priority patent/DE2436772C2/en
Priority to FR7426655A priority patent/FR2239473B1/fr
Priority to CH1051874A priority patent/CH614924A5/en
Priority to DK408674*A priority patent/DK408674A/da
Priority to HU74GA165A priority patent/HU173065B/en
Priority to CA206,012A priority patent/CA1031769A/en
Priority to NL7410293A priority patent/NL7410293A/en
Priority to SU7402051820A priority patent/SU578863A3/en
Priority to ZA00744905A priority patent/ZA744905B/en
Priority to SE7409886A priority patent/SE7409886L/
Priority to AU71880/74A priority patent/AU493106B2/en
Priority to JP49087087A priority patent/JPS5829299B2/en
Priority to AT628374A priority patent/AT335606B/en
Priority to BE147180A priority patent/BE818367A/en
Priority to US05/671,935 priority patent/US4059573A/en
Publication of GB1479141A publication Critical patent/GB1479141A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

N-blocked amino acids and N-blocked peptides are obtained in the form of their esters from their aqueous solutions or slurries with the aid of a novel extraction process, wherein the N-blocked amino acid or the N-blocked peptide is converted to a water-insoluble ester by treating the solution with a diazo compound containing the ester group to be introduced, in the presence of a water-immiscible solvent, resulting in a solution of the ester in the organic solvent. Diazo compounds particularly suitable for this process correspond to the formula (I) <IMAGE> wherein R<1> denotes a hydrogen atom or an organic group and R<2> denotes an organic group, or R<1> and R<2> together with the carbon atom to which they are bonded form a cyclic organic group. The process is applied with particular advantage to the isolation of penicillins and cephalosporins from fermentation broths.
GB36498/73A 1973-08-01 1973-08-01 Extraction of n-blocked amino acid from aqueous solutions Expired GB1479141A (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
GB36498/73A GB1479141A (en) 1973-08-01 1973-08-01 Extraction of n-blocked amino acid from aqueous solutions
ES428799A ES428799A1 (en) 1973-08-01 1974-07-31 Extraction of n-blocked amino acid from aqueous solutions
IE1625/74A IE39650B1 (en) 1973-08-01 1974-07-31 Extraction of n-blocked amino acids from aqueous solutions
DE2436772A DE2436772C2 (en) 1973-08-01 1974-07-31 Process for the extraction of N-blocked cephalosporin or penicillin compounds from their aqueous solutions
FR7426655A FR2239473B1 (en) 1973-08-01 1974-07-31
CH1051874A CH614924A5 (en) 1973-08-01 1974-07-31 Process for extracting N-blocked amino acids or N-blocked peptides from an aqueous solution or slurry
DK408674*A DK408674A (en) 1973-08-01 1974-07-31
HU74GA165A HU173065B (en) 1973-08-01 1974-07-31 Process for extracting n-protected amino acids
CA206,012A CA1031769A (en) 1973-08-01 1974-07-31 Extraction of n-blocked amino acids
NL7410293A NL7410293A (en) 1973-08-01 1974-07-31 METHOD OF EXTRACTING AN N-BLOCKED AMINO ACID.
SU7402051820A SU578863A3 (en) 1973-08-01 1974-07-31 Method of separating esters of n-substited amino acids from their water solutions
ZA00744905A ZA744905B (en) 1973-08-01 1974-07-31 Extration process
SE7409886A SE7409886L (en) 1973-08-01 1974-07-31
AU71880/74A AU493106B2 (en) 1973-08-01 1974-07-31 Extraction process
JP49087087A JPS5829299B2 (en) 1973-08-01 1974-07-31 how to use ester
AT628374A AT335606B (en) 1973-08-01 1974-07-31 PROCESS FOR THE EXTRACTIVE ESTERIFICATION OF AN N-BLOCKED AMINO ACID, IN PARTICULAR A PENICILLIN OR CEPHALOSPORIN
BE147180A BE818367A (en) 1973-08-01 1974-08-01 PROCESS FOR RECOVERING BLOCKED NITROGEN AMINO ACIDS
US05/671,935 US4059573A (en) 1973-08-01 1976-03-30 Extraction of N-blocked amino acids from aqueous media

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB36498/73A GB1479141A (en) 1973-08-01 1973-08-01 Extraction of n-blocked amino acid from aqueous solutions

Publications (1)

Publication Number Publication Date
GB1479141A true GB1479141A (en) 1977-07-06

Family

ID=10388720

Family Applications (1)

Application Number Title Priority Date Filing Date
GB36498/73A Expired GB1479141A (en) 1973-08-01 1973-08-01 Extraction of n-blocked amino acid from aqueous solutions

Country Status (16)

Country Link
JP (1) JPS5829299B2 (en)
AT (1) AT335606B (en)
BE (1) BE818367A (en)
CA (1) CA1031769A (en)
CH (1) CH614924A5 (en)
DE (1) DE2436772C2 (en)
DK (1) DK408674A (en)
ES (1) ES428799A1 (en)
FR (1) FR2239473B1 (en)
GB (1) GB1479141A (en)
HU (1) HU173065B (en)
IE (1) IE39650B1 (en)
NL (1) NL7410293A (en)
SE (1) SE7409886L (en)
SU (1) SU578863A3 (en)
ZA (1) ZA744905B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102120185B (en) * 2010-04-12 2013-06-12 上海海嘉诺医药发展股份有限公司 Supported solid catalyst and preparation method and use thereof

Also Published As

Publication number Publication date
BE818367A (en) 1975-02-03
DK408674A (en) 1975-03-24
IE39650L (en) 1975-02-01
DE2436772C2 (en) 1986-03-06
SE7409886L (en) 1975-03-20
JPS5829299B2 (en) 1983-06-22
NL7410293A (en) 1975-02-04
CA1031769A (en) 1978-05-23
FR2239473B1 (en) 1978-08-11
AT335606B (en) 1977-03-25
ATA628374A (en) 1976-07-15
AU7188074A (en) 1976-02-05
FR2239473A1 (en) 1975-02-28
SU578863A3 (en) 1977-10-30
DE2436772A1 (en) 1975-02-20
HU173065B (en) 1979-02-28
ZA744905B (en) 1975-09-24
CH614924A5 (en) 1979-12-28
ES428799A1 (en) 1976-09-16
JPS5076003A (en) 1975-06-21
IE39650B1 (en) 1978-11-22

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Legal Events

Date Code Title Description
PS Patent sealed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PCNP Patent ceased through non-payment of renewal fee