GB1479141A - Extraction of n-blocked amino acid from aqueous solutions - Google Patents
Extraction of n-blocked amino acid from aqueous solutionsInfo
- Publication number
- GB1479141A GB1479141A GB36498/73A GB3649873A GB1479141A GB 1479141 A GB1479141 A GB 1479141A GB 36498/73 A GB36498/73 A GB 36498/73A GB 3649873 A GB3649873 A GB 3649873A GB 1479141 A GB1479141 A GB 1479141A
- Authority
- GB
- United Kingdom
- Prior art keywords
- blocked
- amino acid
- aqueous solutions
- ester
- blocked amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
N-blocked amino acids and N-blocked peptides are obtained in the form of their esters from their aqueous solutions or slurries with the aid of a novel extraction process, wherein the N-blocked amino acid or the N-blocked peptide is converted to a water-insoluble ester by treating the solution with a diazo compound containing the ester group to be introduced, in the presence of a water-immiscible solvent, resulting in a solution of the ester in the organic solvent. Diazo compounds particularly suitable for this process correspond to the formula (I) <IMAGE> wherein R<1> denotes a hydrogen atom or an organic group and R<2> denotes an organic group, or R<1> and R<2> together with the carbon atom to which they are bonded form a cyclic organic group. The process is applied with particular advantage to the isolation of penicillins and cephalosporins from fermentation broths.
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB36498/73A GB1479141A (en) | 1973-08-01 | 1973-08-01 | Extraction of n-blocked amino acid from aqueous solutions |
ES428799A ES428799A1 (en) | 1973-08-01 | 1974-07-31 | Extraction of n-blocked amino acid from aqueous solutions |
IE1625/74A IE39650B1 (en) | 1973-08-01 | 1974-07-31 | Extraction of n-blocked amino acids from aqueous solutions |
DE2436772A DE2436772C2 (en) | 1973-08-01 | 1974-07-31 | Process for the extraction of N-blocked cephalosporin or penicillin compounds from their aqueous solutions |
FR7426655A FR2239473B1 (en) | 1973-08-01 | 1974-07-31 | |
CH1051874A CH614924A5 (en) | 1973-08-01 | 1974-07-31 | Process for extracting N-blocked amino acids or N-blocked peptides from an aqueous solution or slurry |
DK408674*A DK408674A (en) | 1973-08-01 | 1974-07-31 | |
HU74GA165A HU173065B (en) | 1973-08-01 | 1974-07-31 | Process for extracting n-protected amino acids |
CA206,012A CA1031769A (en) | 1973-08-01 | 1974-07-31 | Extraction of n-blocked amino acids |
NL7410293A NL7410293A (en) | 1973-08-01 | 1974-07-31 | METHOD OF EXTRACTING AN N-BLOCKED AMINO ACID. |
SU7402051820A SU578863A3 (en) | 1973-08-01 | 1974-07-31 | Method of separating esters of n-substited amino acids from their water solutions |
ZA00744905A ZA744905B (en) | 1973-08-01 | 1974-07-31 | Extration process |
SE7409886A SE7409886L (en) | 1973-08-01 | 1974-07-31 | |
AU71880/74A AU493106B2 (en) | 1973-08-01 | 1974-07-31 | Extraction process |
JP49087087A JPS5829299B2 (en) | 1973-08-01 | 1974-07-31 | how to use ester |
AT628374A AT335606B (en) | 1973-08-01 | 1974-07-31 | PROCESS FOR THE EXTRACTIVE ESTERIFICATION OF AN N-BLOCKED AMINO ACID, IN PARTICULAR A PENICILLIN OR CEPHALOSPORIN |
BE147180A BE818367A (en) | 1973-08-01 | 1974-08-01 | PROCESS FOR RECOVERING BLOCKED NITROGEN AMINO ACIDS |
US05/671,935 US4059573A (en) | 1973-08-01 | 1976-03-30 | Extraction of N-blocked amino acids from aqueous media |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB36498/73A GB1479141A (en) | 1973-08-01 | 1973-08-01 | Extraction of n-blocked amino acid from aqueous solutions |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1479141A true GB1479141A (en) | 1977-07-06 |
Family
ID=10388720
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB36498/73A Expired GB1479141A (en) | 1973-08-01 | 1973-08-01 | Extraction of n-blocked amino acid from aqueous solutions |
Country Status (16)
Country | Link |
---|---|
JP (1) | JPS5829299B2 (en) |
AT (1) | AT335606B (en) |
BE (1) | BE818367A (en) |
CA (1) | CA1031769A (en) |
CH (1) | CH614924A5 (en) |
DE (1) | DE2436772C2 (en) |
DK (1) | DK408674A (en) |
ES (1) | ES428799A1 (en) |
FR (1) | FR2239473B1 (en) |
GB (1) | GB1479141A (en) |
HU (1) | HU173065B (en) |
IE (1) | IE39650B1 (en) |
NL (1) | NL7410293A (en) |
SE (1) | SE7409886L (en) |
SU (1) | SU578863A3 (en) |
ZA (1) | ZA744905B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102120185B (en) * | 2010-04-12 | 2013-06-12 | 上海海嘉诺医药发展股份有限公司 | Supported solid catalyst and preparation method and use thereof |
-
1973
- 1973-08-01 GB GB36498/73A patent/GB1479141A/en not_active Expired
-
1974
- 1974-07-31 SU SU7402051820A patent/SU578863A3/en active
- 1974-07-31 NL NL7410293A patent/NL7410293A/en not_active Application Discontinuation
- 1974-07-31 CH CH1051874A patent/CH614924A5/en not_active IP Right Cessation
- 1974-07-31 JP JP49087087A patent/JPS5829299B2/en not_active Expired
- 1974-07-31 DE DE2436772A patent/DE2436772C2/en not_active Expired
- 1974-07-31 SE SE7409886A patent/SE7409886L/ not_active Application Discontinuation
- 1974-07-31 FR FR7426655A patent/FR2239473B1/fr not_active Expired
- 1974-07-31 HU HU74GA165A patent/HU173065B/en unknown
- 1974-07-31 ES ES428799A patent/ES428799A1/en not_active Expired
- 1974-07-31 IE IE1625/74A patent/IE39650B1/en unknown
- 1974-07-31 ZA ZA00744905A patent/ZA744905B/en unknown
- 1974-07-31 CA CA206,012A patent/CA1031769A/en not_active Expired
- 1974-07-31 DK DK408674*A patent/DK408674A/da not_active Application Discontinuation
- 1974-07-31 AT AT628374A patent/AT335606B/en not_active IP Right Cessation
- 1974-08-01 BE BE147180A patent/BE818367A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BE818367A (en) | 1975-02-03 |
DK408674A (en) | 1975-03-24 |
IE39650L (en) | 1975-02-01 |
DE2436772C2 (en) | 1986-03-06 |
SE7409886L (en) | 1975-03-20 |
JPS5829299B2 (en) | 1983-06-22 |
NL7410293A (en) | 1975-02-04 |
CA1031769A (en) | 1978-05-23 |
FR2239473B1 (en) | 1978-08-11 |
AT335606B (en) | 1977-03-25 |
ATA628374A (en) | 1976-07-15 |
AU7188074A (en) | 1976-02-05 |
FR2239473A1 (en) | 1975-02-28 |
SU578863A3 (en) | 1977-10-30 |
DE2436772A1 (en) | 1975-02-20 |
HU173065B (en) | 1979-02-28 |
ZA744905B (en) | 1975-09-24 |
CH614924A5 (en) | 1979-12-28 |
ES428799A1 (en) | 1976-09-16 |
JPS5076003A (en) | 1975-06-21 |
IE39650B1 (en) | 1978-11-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
PCNP | Patent ceased through non-payment of renewal fee |