GB974334A - Vitamin b antagonist factor and the preparation thereof - Google Patents

Vitamin b antagonist factor and the preparation thereof

Info

Publication number
GB974334A
GB974334A GB1152161A GB1152161A GB974334A GB 974334 A GB974334 A GB 974334A GB 1152161 A GB1152161 A GB 1152161A GB 1152161 A GB1152161 A GB 1152161A GB 974334 A GB974334 A GB 974334A
Authority
GB
United Kingdom
Prior art keywords
vitamin
derivative
solvent
fermentation broth
water insoluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1152161A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of GB974334A publication Critical patent/GB974334A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/42—Cobalamins, i.e. vitamin B12, LLD factor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A derivative of vitamin B12, said derivative being antagonistic to vitamin B12 and being a compound in which one particular amide group of vitamin B12 is replaced by a carboxylic acid group, is obtained in a process which comprises fermenting the vitamin B12 antagonist-producing microorganism Propionibacterium shermanii PBS 77 to produce a fermentation broth containing said derivative of vitamin B12, and then separating the said derivative of vitamin B12 from the vitamin B12 and other ingredients of the fermentation broth. The separation includes one of the following steps: (a) solvent extraction using a water insoluble organic solvent at pH7 to remove the vitamin B12 in the solvent layer followed by solvent extraction using a water insoluble organic solvent of the aqueous layer at pH 2-4.5 to obtain said derivative in the solvent layer; (b) adsorbing the derivative of vitamin B12 on to an alkaline anion exchange resin; (c) electrodialysis. A pharmaceutical composition containing said derivative of vitamin B12 together with a pharmaceutical carrier or excipient, is suitable for intramuscular injection against polycythaemia.
GB1152161A 1960-03-29 1961-03-29 Vitamin b antagonist factor and the preparation thereof Expired GB974334A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUGO000749 1960-03-29

Publications (1)

Publication Number Publication Date
GB974334A true GB974334A (en) 1964-11-04

Family

ID=10996630

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1152161A Expired GB974334A (en) 1960-03-29 1961-03-29 Vitamin b antagonist factor and the preparation thereof

Country Status (3)

Country Link
CH (1) CH392779A (en)
GB (1) GB974334A (en)
SE (1) SE303465B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7951913B2 (en) 2006-06-02 2011-05-31 Biotika A.S. Method of polymyxin B recovery from fermentation broth
US8119371B2 (en) 2006-06-15 2012-02-21 Biotika A.S. Process for the preparation of polymyxin B employing (PAENI) Bacillus polymyxa

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7951913B2 (en) 2006-06-02 2011-05-31 Biotika A.S. Method of polymyxin B recovery from fermentation broth
US8119371B2 (en) 2006-06-15 2012-02-21 Biotika A.S. Process for the preparation of polymyxin B employing (PAENI) Bacillus polymyxa

Also Published As

Publication number Publication date
SE303465B (en) 1968-09-02
CH392779A (en) 1965-05-31

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