GB1472627A - Benzylaminoalkanoic acids process for their preparation and pharmaceutical compositions containing them - Google Patents

Benzylaminoalkanoic acids process for their preparation and pharmaceutical compositions containing them

Info

Publication number
GB1472627A
GB1472627A GB3944374A GB3944374A GB1472627A GB 1472627 A GB1472627 A GB 1472627A GB 3944374 A GB3944374 A GB 3944374A GB 3944374 A GB3944374 A GB 3944374A GB 1472627 A GB1472627 A GB 1472627A
Authority
GB
United Kingdom
Prior art keywords
formula
acid
condensing
compounds
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3944374A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Priority to GB3944374A priority Critical patent/GB1472627A/en
Priority to SU752167228A priority patent/SU660588A3/en
Priority to DK396175A priority patent/DK145080C/en
Priority to SE7510024A priority patent/SE420917B/en
Priority to ES440831A priority patent/ES440831A1/en
Priority to CA235,367A priority patent/CA1063619A/en
Priority to BE159885A priority patent/BE833238A/en
Priority to AU84648/75A priority patent/AU489940B2/en
Priority to JP10942475A priority patent/JPS5645905B2/ja
Priority to FR7527536A priority patent/FR2284322A1/en
Priority to NL7510588.A priority patent/NL166253C/en
Priority to CH7511709A priority patent/CH608784A5/en
Priority to DE2540334A priority patent/DE2540334C2/en
Priority to ZA00755777A priority patent/ZA755777B/en
Publication of GB1472627A publication Critical patent/GB1472627A/en
Priority to PH24126A priority patent/PH16279A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/395—Saturated compounds containing a keto group being part of a ring of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/403—Saturated compounds containing a keto group being part of a ring of a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/295—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with inorganic bases, e.g. by alkali fusion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1472627 Benzylamino - alkanoic acids SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 10 Sept 1975 [10 Sept 1974] 39443/74 Heading C2C The invention comprises compounds of the formula wherein R 1 is a (C 3 -C 6 ) straight or branched chain alkyl radical, each of R 2 and R 4 is H or a (C 1 -C 5 ) straight or branched chain alkyl radical, R 3 is H, halogen, diethylaminoethoxy alkoxy or CF 3 , A and B are each selected from H, CH 3 or C 2 H 5 , and n is an integer from 4 to 10; including optically active isomers thereof and salts with acids or bases. They may be obtained by condensing an oxoalkanoic acid of the formula with a benzylamine of the formula reducing the product obtained, and if salts are required, adding thereto a mineral or organic base or acid. Pharmaceutical compositions having anti. aggressive activity comprise compounds of formula I above in admixture with a pharmaceutically suitable carrier. They may be applied parenterally, orally or rectally. Compounds of formula II above may be obtained by submitting a cyclic #-diketone of the formula to alkaline cleavage and recovering the corresponding oxoalkanoic acid. Cyclic #-diketones of formula IV above may be obtained by condensing a cycloalkenylamine of the formula wherein X and Y are lower alkyl or phenyl or together form an alkylene chain which may contain another hetero atom, with a functional derivative of a carboxylic acid of the formula R 1 COZ wherein Z is halogen or R 1 COO. 1 - Morpholino - cyclohex - 1 - ene is obtained by condensing cyclohexanone with morpholine with the aid of p-toluene sulphonic acid, in the presence of benzene.
GB3944374A 1974-09-10 1974-09-10 Benzylaminoalkanoic acids process for their preparation and pharmaceutical compositions containing them Expired GB1472627A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
GB3944374A GB1472627A (en) 1974-09-10 1974-09-10 Benzylaminoalkanoic acids process for their preparation and pharmaceutical compositions containing them
SU752167228A SU660588A3 (en) 1974-09-10 1975-09-01 Method of obtaining benzilaminoalkane acids or salts thereof
DK396175A DK145080C (en) 1974-09-10 1975-09-04 METHOD OF ANALOGUE FOR THE PREPARATION OF BENZYLAMINOALKANIC ACIDS OR SALTS OR OPTICALLY ACTIVE ISOMERS THEREOF
AU84648/75A AU489940B2 (en) 1974-09-10 1975-09-09 New benzylaminoalkanoic acids, processes for making them and pharmaceutical compositions
NL7510588.A NL166253C (en) 1974-09-10 1975-09-09 PROCESS FOR THE PREPARATION OF COMPOUNDS WITH AN AGGRESSIVE ANTI-AGREEMENT ACTION AND METHOD FOR PREPARING A MEDICINAL PRODUCT WITH SUCH ACTION
CA235,367A CA1063619A (en) 1974-09-10 1975-09-09 Process for the preparation of new benzylamino-acanoic acids ands compounds thereof
BE159885A BE833238A (en) 1974-09-10 1975-09-09 NEW BENZYLAMINO ALKANOIC ACIDS, PROCESS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING
SE7510024A SE420917B (en) 1974-09-10 1975-09-09 SET TO MAKE NEW BENZYLAMINO ALKANIC ACIDS WITH ANTIAGGRESSIVE PROPERTIES
JP10942475A JPS5645905B2 (en) 1974-09-10 1975-09-09
FR7527536A FR2284322A1 (en) 1974-09-10 1975-09-09 NEW BENZYLAMINO ALKANOIC ACIDS, METHODS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING
ES440831A ES440831A1 (en) 1974-09-10 1975-09-09 Benzylaminoalkanoic acids process for their preparation and pharmaceutical compositions containing them
CH7511709A CH608784A5 (en) 1974-09-10 1975-09-10 Process for the preparation of new benzylaminoalkanoic acids
DE2540334A DE2540334C2 (en) 1974-09-10 1975-09-10 Benzylaminoalkanoic acids, processes for their preparation and pharmaceutical preparations containing these compounds
ZA00755777A ZA755777B (en) 1974-09-10 1975-09-10 New benzyl amino alkanoic acids processes for making them and pharmaceutical compositions
PH24126A PH16279A (en) 1974-09-10 1980-06-11 New benzylamino alkanoic acids,their pharmaceutical compositions and their use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3944374A GB1472627A (en) 1974-09-10 1974-09-10 Benzylaminoalkanoic acids process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
GB1472627A true GB1472627A (en) 1977-05-04

Family

ID=10409574

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3944374A Expired GB1472627A (en) 1974-09-10 1974-09-10 Benzylaminoalkanoic acids process for their preparation and pharmaceutical compositions containing them

Country Status (14)

Country Link
JP (1) JPS5645905B2 (en)
BE (1) BE833238A (en)
CA (1) CA1063619A (en)
CH (1) CH608784A5 (en)
DE (1) DE2540334C2 (en)
DK (1) DK145080C (en)
ES (1) ES440831A1 (en)
FR (1) FR2284322A1 (en)
GB (1) GB1472627A (en)
NL (1) NL166253C (en)
PH (1) PH16279A (en)
SE (1) SE420917B (en)
SU (1) SU660588A3 (en)
ZA (1) ZA755777B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2434797A1 (en) * 1978-09-01 1980-03-28 Biochemical Res Corp PREPARATION OF ALCOHOLS AND LONG-DHAINE CARBOXYLIC ACIDS
CN112920042A (en) * 2021-01-27 2021-06-08 北京岳达生物科技有限公司 Method for preparing alkane carboxylic acid by increasing alkane carbon chain

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1545291A (en) * 1976-03-11 1979-05-10 Science Union & Cie Benzylamino-alkanamides process for their preparation and pharmaceutical compositions containing them

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2434797A1 (en) * 1978-09-01 1980-03-28 Biochemical Res Corp PREPARATION OF ALCOHOLS AND LONG-DHAINE CARBOXYLIC ACIDS
CN112920042A (en) * 2021-01-27 2021-06-08 北京岳达生物科技有限公司 Method for preparing alkane carboxylic acid by increasing alkane carbon chain

Also Published As

Publication number Publication date
ZA755777B (en) 1976-08-25
ES440831A1 (en) 1977-03-01
BE833238A (en) 1976-03-09
DE2540334A1 (en) 1976-03-25
NL166253B (en) 1981-02-16
CH608784A5 (en) 1979-01-31
SE7510024L (en) 1976-03-11
PH16279A (en) 1983-08-26
JPS5645905B2 (en) 1981-10-29
AU8464875A (en) 1977-03-17
DK145080C (en) 1983-01-24
SE420917B (en) 1981-11-09
NL166253C (en) 1981-07-15
CA1063619A (en) 1979-10-02
DK396175A (en) 1976-03-11
DK145080B (en) 1982-08-23
FR2284322B1 (en) 1978-07-28
JPS5159826A (en) 1976-05-25
DE2540334C2 (en) 1983-03-10
NL7510588A (en) 1976-03-12
FR2284322A1 (en) 1976-04-09
SU660588A3 (en) 1979-04-30

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19920910