GB1465946A - Pyridazinyl,pyrimidinyl,pyrazinyl and pyridyl compounds and processes for their manufacture - Google Patents

Pyridazinyl,pyrimidinyl,pyrazinyl and pyridyl compounds and processes for their manufacture

Info

Publication number
GB1465946A
GB1465946A GB651874A GB651874A GB1465946A GB 1465946 A GB1465946 A GB 1465946A GB 651874 A GB651874 A GB 651874A GB 651874 A GB651874 A GB 651874A GB 1465946 A GB1465946 A GB 1465946A
Authority
GB
United Kingdom
Prior art keywords
alkyl
het
dihydroxypropoxy
dichloropyrimidine
allyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB651874A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH244473A external-priority patent/CH584209A5/de
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of GB1465946A publication Critical patent/GB1465946A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB651874A 1973-02-20 1974-02-13 Pyridazinyl,pyrimidinyl,pyrazinyl and pyridyl compounds and processes for their manufacture Expired GB1465946A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH244473A CH584209A5 (en) 1973-02-20 1973-02-20 3-amino-2-hydroxypropoxy substd. diazines and pyridines - with beta-adrenergic blocking or stimulating activity
FI193/74A FI60391C (fi) 1973-02-20 1974-01-23 Analogifoerfarande foer framstaellning av beta-reseptor-aktiva 1-heterocyklyloxi-3-amino-2-propanolfoereningar

Publications (1)

Publication Number Publication Date
GB1465946A true GB1465946A (en) 1977-03-02

Family

ID=25690464

Family Applications (1)

Application Number Title Priority Date Filing Date
GB651874A Expired GB1465946A (en) 1973-02-20 1974-02-13 Pyridazinyl,pyrimidinyl,pyrazinyl and pyridyl compounds and processes for their manufacture

Country Status (15)

Country Link
AR (6) AR207133A1 (sv)
AT (1) AT335455B (sv)
BE (1) BE811274A (sv)
CA (1) CA1027131A (sv)
CS (1) CS203970B2 (sv)
DD (1) DD110041A5 (sv)
DE (1) DE2406930A1 (sv)
DK (1) DK143501C (sv)
ES (2) ES446081A1 (sv)
FR (1) FR2218101B1 (sv)
GB (1) GB1465946A (sv)
IE (1) IE38839B1 (sv)
IL (1) IL44202A (sv)
LU (1) LU69415A1 (sv)
SE (1) SE420834B (sv)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006614A2 (en) * 1978-06-27 1980-01-09 Merck & Co. Inc. Pyridyl- and imidazopyridyloxypropanolamines, process for preparing the same and pharmaceutical compositions containing the same
EP0007448A1 (en) * 1978-06-27 1980-02-06 Merck & Co. Inc. Pyridyloxypropanolamines and esters thereof, process for preparing the same and pharmaceutical compositions containing them
EP0009075A1 (en) * 1978-06-27 1980-04-02 Merck & Co. Inc. Pyridyloxy-propanol amines and esters thereof, process for preparing the same and pharmaceutical compositions containing them
US4279913A (en) * 1978-01-04 1981-07-21 Merck & Co., Inc. Polysubstituted-2-(3-loweralkylamino-2-R1 O-propoxy)pyridines
US4281005A (en) 1979-03-05 1981-07-28 Merck & Co., Inc. Novel 2-pyridylimidazole compounds
US4294969A (en) * 1979-01-29 1981-10-13 Merck & Co., Inc. Process for producing 2-bromo-3,5-disubstituted pyridines
US4393212A (en) * 1979-01-29 1983-07-12 Merck & Co., Inc. Certain nicotinic acid esters and corresponding nicotinonitriles
GB2139623A (en) * 1983-05-09 1984-11-14 Bristol Myers Co 1-pyrimidinyloxy-3-alkylamino-2-propanols
EP0153746A2 (en) * 1984-03-02 1985-09-04 Merck & Co. Inc. 3-Amino-2-hydroxypropyl derivatives of pyrimidin-4-one
US6465467B1 (en) 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
WO2003044015A2 (en) * 2001-11-15 2003-05-30 The Institutes For Pharmaceutical Discovery, Llc Substituted heteroarylalkanoic acids and their use as aldose reductase inhibitors
WO2004000830A1 (en) 2002-06-19 2003-12-31 Biovitrum Ab Novel compounds, their use and preparation
WO2004050657A2 (en) * 2002-11-27 2004-06-17 Artesian Therapeutics, Inc. COMPOUNDS WITH MIXED PDE-INHIBITORY AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE
EP2482657A1 (en) * 2009-09-21 2012-08-08 Vanderbilt University O-benzyl nicotinamide analogs as mglur5 positive allosteric modulators

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195090A (en) * 1973-02-20 1980-03-25 Ciba-Geigy Corporation 2-(3-Amino-2-hydroxy-propoxy)pyridine derivatives and pharmaceutical compositions therewith
US4000282A (en) * 1974-12-16 1976-12-28 Merck & Co., Inc. 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines
JPS5283759A (en) * 1976-01-01 1977-07-12 Merck & Co Inc Substituted pyridines
US4091104A (en) * 1976-06-15 1978-05-23 Merck & Co., Inc. Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their preparation and use
US4092419A (en) * 1976-06-15 1978-05-30 Merck & Co., Inc. Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their preparation and use
US4060601A (en) * 1976-06-15 1977-11-29 Merck & Co., Inc. Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines
DE2711655A1 (de) * 1977-03-17 1978-09-21 Basf Ag Pyridinyl-aminoalkylaether
US4166851A (en) * 1977-05-16 1979-09-04 Merck & Co., Inc. Certain imidazo(1,2a)pyridine derivatives
US4753673A (en) * 1977-07-22 1988-06-28 The Dow Chemical Company Trifluoromethyl pyridinyloxyphenoxy and pyridinylthiophenoxy propanoic acids and propanols and derivatives thereof and methods of herbicidal use
US4144343A (en) * 1978-01-04 1979-03-13 Merck & Co., Inc. Heterocycle substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines
JPS54106476A (en) * 1978-01-04 1979-08-21 Merck & Co Inc Multiisubstituted 22*33lower alkylaminoo22 r100propoxy*pyridine
DD150456A5 (de) * 1979-03-01 1981-09-02 Ciba Geigy Ag Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols
IT1165040B (it) * 1979-04-23 1987-04-22 Isf Spa Alcossialchilidenidrazinopiridazione e procedimento per la loro preparazione
DE2943774A1 (de) * 1979-10-26 1981-05-14 1000 Berlin Schering Ag Berlin Und Bergkamen Substituierte pyridine, verfahren zu ihrer herstellung und ihre verwendung
IL62602A (en) * 1980-05-19 1984-06-29 Labaz Sanofi Nv Pyridoxine derivatives,their preparation and pharmaceutical compositions containing them
FR2502618A1 (fr) * 1981-03-25 1982-10-01 Synthelabo Derives de pyridine, leur preparation et leur application en therapeutique
US20080033020A1 (en) * 2004-07-23 2008-02-07 Darren Mansfield 3-Pyridinylethylbenzamide Derivatives as Fungicides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1001631A (en) * 1972-05-05 1976-12-14 Merck Sharp And Dohme (I.A.) Corp. 2-(3-substituted amino-2-hydroxy-propoxy)-3-substituted pyrazines and method for preparation

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4279913A (en) * 1978-01-04 1981-07-21 Merck & Co., Inc. Polysubstituted-2-(3-loweralkylamino-2-R1 O-propoxy)pyridines
EP0006614A2 (en) * 1978-06-27 1980-01-09 Merck & Co. Inc. Pyridyl- and imidazopyridyloxypropanolamines, process for preparing the same and pharmaceutical compositions containing the same
EP0006614A3 (en) * 1978-06-27 1980-01-23 Merck & Co. Inc. Pyridyl- and imidazopyridyloxypropanolamines, process for preparing the same and pharmaceutical compositions containing the same
EP0007448A1 (en) * 1978-06-27 1980-02-06 Merck & Co. Inc. Pyridyloxypropanolamines and esters thereof, process for preparing the same and pharmaceutical compositions containing them
EP0009075A1 (en) * 1978-06-27 1980-04-02 Merck & Co. Inc. Pyridyloxy-propanol amines and esters thereof, process for preparing the same and pharmaceutical compositions containing them
US4208416A (en) * 1978-06-27 1980-06-17 Merck & Co., Inc. N-Aralkyl containing cyanopyridines
US4294969A (en) * 1979-01-29 1981-10-13 Merck & Co., Inc. Process for producing 2-bromo-3,5-disubstituted pyridines
US4393212A (en) * 1979-01-29 1983-07-12 Merck & Co., Inc. Certain nicotinic acid esters and corresponding nicotinonitriles
US4281005A (en) 1979-03-05 1981-07-28 Merck & Co., Inc. Novel 2-pyridylimidazole compounds
GB2139623A (en) * 1983-05-09 1984-11-14 Bristol Myers Co 1-pyrimidinyloxy-3-alkylamino-2-propanols
FR2545825A1 (fr) * 1983-05-09 1984-11-16 Bristol Myers Co 1-pyrimidinyloxy-3-hetarylalkylamino-2-propanols, leur preparation et leurs utilisations therapeutiques
AU576761B2 (en) * 1983-05-09 1988-09-08 Bristol-Myers Company Pyrimidine derivatives
EP0153746A3 (en) * 1984-03-02 1986-06-11 Merck & Co. Inc. 3-amino-2-hydroxypropyl derivatives of pyrimidin-4-one
EP0153746A2 (en) * 1984-03-02 1985-09-04 Merck & Co. Inc. 3-Amino-2-hydroxypropyl derivatives of pyrimidin-4-one
US6465467B1 (en) 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
US7071180B2 (en) 1999-05-21 2006-07-04 Biovitrum Ab Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
US7534794B2 (en) 1999-05-21 2009-05-19 Biovitrum Ab Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
WO2003044015A2 (en) * 2001-11-15 2003-05-30 The Institutes For Pharmaceutical Discovery, Llc Substituted heteroarylalkanoic acids and their use as aldose reductase inhibitors
WO2003044015A3 (en) * 2001-11-15 2003-10-02 Inst For Pharm Discovery Inc Substituted heteroarylalkanoic acids and their use as aldose reductase inhibitors
WO2004000830A1 (en) 2002-06-19 2003-12-31 Biovitrum Ab Novel compounds, their use and preparation
WO2004050657A2 (en) * 2002-11-27 2004-06-17 Artesian Therapeutics, Inc. COMPOUNDS WITH MIXED PDE-INHIBITORY AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE
WO2004050657A3 (en) * 2002-11-27 2004-11-25 Artesian Therapeutics Inc COMPOUNDS WITH MIXED PDE-INHIBITORY AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE
JP2006509790A (ja) * 2002-11-27 2006-03-23 アルテシアン セラピューティック，インコーポレイティド 心不全の治療のための混合されたＰＤＥ阻害およびβアドレナリン拮抗薬活性または部分的作用薬活性を有する化合物
EP2482657A1 (en) * 2009-09-21 2012-08-08 Vanderbilt University O-benzyl nicotinamide analogs as mglur5 positive allosteric modulators
EP2482657A4 (en) * 2009-09-21 2013-05-15 Univ Vanderbilt O-BENZYL-NICOTINAMIDANALOGA AS POSITIVE ALLOSTERIC MGLUR5 MODULATORS

Also Published As

Publication number Publication date
AR203878A1 (es) 1975-10-31
ATA133074A (de) 1976-07-15
AR206801A1 (es) 1976-08-23
IE38839L (en) 1974-08-20
AR208043A1 (es) 1976-11-22
DE2406930A1 (de) 1974-08-22
ES446083A1 (es) 1977-09-16
IE38839B1 (en) 1978-06-07
CS203970B2 (en) 1981-03-31
DD110041A5 (sv) 1974-12-05
AT335455B (de) 1977-03-10
ES446081A1 (es) 1977-06-16
CA1027131A (en) 1978-02-28
AR208397A1 (es) 1976-12-27
FR2218101A1 (sv) 1974-09-13
AR214612A1 (es) 1979-07-13
DK143501B (da) 1981-08-31
LU69415A1 (sv) 1975-12-09
AR207133A1 (es) 1976-09-15
IL44202A0 (en) 1974-06-30
BE811274A (fr) 1974-08-19
FR2218101B1 (sv) 1977-07-15
IL44202A (en) 1978-10-31
DK143501C (da) 1982-02-22
SE420834B (sv) 1981-11-02

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee