GB1464902A - Production of d-penicillamine - Google Patents
Production of d-penicillamineInfo
- Publication number
- GB1464902A GB1464902A GB3408674A GB3408674A GB1464902A GB 1464902 A GB1464902 A GB 1464902A GB 3408674 A GB3408674 A GB 3408674A GB 3408674 A GB3408674 A GB 3408674A GB 1464902 A GB1464902 A GB 1464902A
- Authority
- GB
- United Kingdom
- Prior art keywords
- penicillanine
- acid
- penicillin
- penicilloic
- mercuric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- VVNCNSJFMMFHPL-VKHMYHEASA-N D-penicillamine Chemical compound CC(C)(S)[C@@H](N)C(O)=O VVNCNSJFMMFHPL-VKHMYHEASA-N 0.000 title 1
- 229960001639 penicillamine Drugs 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- OPEGYZAATHKDEM-HCWXCVPCSA-N (2r,4s)-2-[(r)-carboxy(formamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid Chemical compound CC1(C)S[C@H]([C@H](NC=O)C(O)=O)N[C@H]1C(O)=O OPEGYZAATHKDEM-HCWXCVPCSA-N 0.000 abstract 2
- LRWFMQCGNBOTQP-UHFFFAOYSA-N 5,5-dimethyl-2-[[(2-phenylacetyl)amino]methyl]-1,3-thiazolidin-3-ium-4-carboxylate Chemical compound N1C(C(O)=O)C(C)(C)SC1CNC(=O)CC1=CC=CC=C1 LRWFMQCGNBOTQP-UHFFFAOYSA-N 0.000 abstract 2
- 229930182555 Penicillin Natural products 0.000 abstract 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 2
- 229940049954 penicillin Drugs 0.000 abstract 2
- 102100039993 Hairy/enhancer-of-split related with YRPW motif-like protein Human genes 0.000 abstract 1
- 101001035082 Homo sapiens Hairy/enhancer-of-split related with YRPW motif-like protein Proteins 0.000 abstract 1
- IYNDLOXRXUOGIU-LQDWTQKMSA-M benzylpenicillin potassium Chemical compound [K+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 IYNDLOXRXUOGIU-LQDWTQKMSA-M 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 230000000911 decarboxylating effect Effects 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 230000000593 degrading effect Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/10—Mercury compounds
- C07F3/103—Mercury compounds without C-Mercury linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1464902 D-Penicillanine HEYL & CO CHEMISCH - PHARMAZEUTISCHE FABRIK 1 Aug 1974 [19 March 1974] 34086/74 Heading C2C D-Penicillanine or an acid addition salt thereof is prepared by (i) hydrolytically degrading a 10 to 40% by weight crude aqueous concentrate of a penicillin obtained by a fermentation process (ii) optionally decarboxylating the penicilloic acid obtained to form a penilloic acid (iii) reacting the penicilloic or penilloic acid obtained with an organic solution of 0À3 to 0À7 moles of a mercuric salt per mole of acid (iv) separating the penicillanine mercuric mercaptide formed, suspending it in water or an organic solvent and decomposing it with H 2 S and (v) recovering D-penicillanine or its acid addition salt from the filtrate after removal of the deposit formed during decomposition. The penicillin used was the potassium salt of benzyl penicillin.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742413185 DE2413185A1 (en) | 1974-03-19 | 1974-03-19 | METHOD FOR PRODUCING D-PENICILLAMINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1464902A true GB1464902A (en) | 1977-02-16 |
Family
ID=5910528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3408674A Expired GB1464902A (en) | 1974-03-19 | 1974-08-01 | Production of d-penicillamine |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS516922A (en) |
| AT (1) | AT331776B (en) |
| BE (1) | BE816649A (en) |
| DE (1) | DE2413185A1 (en) |
| GB (1) | GB1464902A (en) |
| NL (1) | NL7408515A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2560142Y2 (en) * | 1991-07-03 | 1998-01-21 | 財団法人鉄道総合技術研究所 | Low spring constant type track pad |
-
1974
- 1974-03-19 DE DE19742413185 patent/DE2413185A1/en active Pending
- 1974-06-11 AT AT482174A patent/AT331776B/en active
- 1974-06-20 BE BE145703A patent/BE816649A/en unknown
- 1974-06-24 JP JP7217974A patent/JPS516922A/en active Pending
- 1974-06-25 NL NL7408515A patent/NL7408515A/en not_active Application Discontinuation
- 1974-08-01 GB GB3408674A patent/GB1464902A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS516922A (en) | 1976-01-20 |
| DE2413185A1 (en) | 1975-10-16 |
| AT331776B (en) | 1976-08-25 |
| NL7408515A (en) | 1975-09-23 |
| BE816649A (en) | 1974-12-20 |
| ATA482174A (en) | 1975-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |