FR2181784A1 - 4, 6-dichloro-pyrazolopyrimidines prepn - from barbituric acid - Google Patents

4, 6-dichloro-pyrazolopyrimidines prepn - from barbituric acid

Info

Publication number
FR2181784A1
FR2181784A1 FR7307478A FR7307478A FR2181784A1 FR 2181784 A1 FR2181784 A1 FR 2181784A1 FR 7307478 A FR7307478 A FR 7307478A FR 7307478 A FR7307478 A FR 7307478A FR 2181784 A1 FR2181784 A1 FR 2181784A1
Authority
FR
France
Prior art keywords
barbituric acid
formula
pyrazolopyrimidines
prepn
dichloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7307478A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gerot Pharmazeutika GmbH
Original Assignee
Gerot Pharmazeutika GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gerot Pharmazeutika GmbH filed Critical Gerot Pharmazeutika GmbH
Publication of FR2181784A1 publication Critical patent/FR2181784A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

(A) Process for preparing pyrazolo(3,4-d)pyrimidine derivatives of formula (I) (where R is H, alkyl, cycloalkyl, aryl or aralkyl) by subjecting barbituric acid to chloroformylation in a reaction of the Vilsmeier type to give a compound of formula (II) and reacting (II) with a hydrazine of the formula H2NNHR (III) or a hydrate or salt thereof. The reaction of (II) with (III) is pref. carried out in the presence of a tertiary amine. (B) Compounds (I; R is not = H) and (II) are stated to be new, but are not claimed. (I) are pharmaceuticals or intermediates for pharmaceuticals. Simple two-stage process using the inexpensive, readily available starting material barbituric acid.
FR7307478A 1972-03-03 1973-03-02 4, 6-dichloro-pyrazolopyrimidines prepn - from barbituric acid Withdrawn FR2181784A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT179472A AT328414B (en) 1972-03-03 1972-03-03 PROCESS FOR THE PRODUCTION OF 4,6-DICHLORO-PYRAZOLO- (3,4-D) -PYRIMIDINE OR IT'S NEW 1-ARYL OR 1-ARALKYL DERIVATIVES

Publications (1)

Publication Number Publication Date
FR2181784A1 true FR2181784A1 (en) 1973-12-07

Family

ID=3521108

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7307478A Withdrawn FR2181784A1 (en) 1972-03-03 1973-03-02 4, 6-dichloro-pyrazolopyrimidines prepn - from barbituric acid

Country Status (5)

Country Link
JP (1) JPS4899194A (en)
AT (1) AT328414B (en)
DD (1) DD103242A5 (en)
DE (1) DE2310334A1 (en)
FR (1) FR2181784A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507146A (en) * 1982-12-28 1985-03-26 Ciba-Geigy Corporation 2,4-Diamino-6-halo-5-trifluoromethylpyrimidines having herbicidal activity
DE3643456A1 (en) * 1986-12-19 1988-06-23 Bayer Ag CYAN TRICHLOR PYRIDO PYRIMIDINE
EP0285571B1 (en) * 1987-04-02 1992-02-05 Ciba-Geigy Ag Reactive dyes, their preparation and their use
US4952679A (en) * 1987-08-27 1990-08-28 Ciba-Geigy Corporation Fiber-reactive dyes containing a 5-formylpyrimidine moiety
US4918169A (en) * 1987-08-27 1990-04-17 Ciba-Geigy Corporation Fiber-reactive dyestuffs comprising a 5-formylpyrimidine moiety
EP1893585A1 (en) * 2005-06-01 2008-03-05 Fermion Oy Process for the preparation of n-[4-(4-fluorophenyl)-5-formyl-6-isopropyl-pyrimidin-2-yl]-n-methylmethanesulfonamide
JPWO2008081928A1 (en) 2006-12-28 2010-04-30 大正製薬株式会社 Pyrazolopyrimidine compounds

Also Published As

Publication number Publication date
JPS4899194A (en) 1973-12-15
AT328414B (en) 1976-03-25
DD103242A5 (en) 1974-01-12
DE2310334A1 (en) 1973-09-13

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Legal Events

Date Code Title Description
ST Notification of lapse