GB1459506A - Piperidine derivatives - Google Patents
Piperidine derivativesInfo
- Publication number
- GB1459506A GB1459506A GB727874A GB727874A GB1459506A GB 1459506 A GB1459506 A GB 1459506A GB 727874 A GB727874 A GB 727874A GB 727874 A GB727874 A GB 727874A GB 1459506 A GB1459506 A GB 1459506A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- possibly substituted
- compounds
- feb
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003053 piperidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 abstract 1
- 235000013877 carbamide Nutrition 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- LWMPFIOTEAXAGV-UHFFFAOYSA-N piperidin-1-amine Chemical compound NN1CCCCC1 LWMPFIOTEAXAGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 150000003585 thioureas Chemical class 0.000 abstract 1
- 150000003672 ureas Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB727874A GB1459506A (en) | 1974-02-18 | 1974-02-18 | Piperidine derivatives |
IE14275A IE40632B1 (en) | 1974-02-18 | 1975-01-24 | Piperidine derivatives |
DE19752505500 DE2505500A1 (de) | 1974-02-18 | 1975-02-10 | Piperidin-derivate, verfahren zu ihrer herstellung und ihre verwendung |
CH161075A CH613191A5 (en, 2012) | 1974-02-18 | 1975-02-11 | |
CH413778A CH612937A5 (en, 2012) | 1974-02-18 | 1975-02-11 | |
US05/549,271 US4073790A (en) | 1974-02-18 | 1975-02-12 | Piperidino ureas and thioureas |
BE153297A BE825458A (fr) | 1974-02-18 | 1975-02-12 | Nouveaux derives de piperidine, leur procede de preparation et compositions pharmaceutiques les contenant |
FR7504834A FR2261008B1 (en, 2012) | 1974-02-18 | 1975-02-17 | |
JP50019659A JPS6031825B2 (ja) | 1974-02-18 | 1975-02-17 | 新規ピペリジン誘導体の製造方法 |
NL7501913A NL7501913A (nl) | 1974-02-18 | 1975-02-18 | Piperidinederivaat alsmede werkwijze voor het bereiden daarvan. |
CA220,677A CA1046065A (en) | 1974-02-18 | 1975-02-18 | 3-(1-(4-phenyl-4-oxobutyl)piperidyl-4-yl) urea compounds |
ZA00754726A ZA754726B (en) | 1974-02-18 | 1975-07-22 | Piperidine derivatives |
IN1449/CAL/75A IN140599B (en, 2012) | 1974-02-18 | 1975-07-25 | |
CH360279A CH615914A5 (en, 2012) | 1974-02-18 | 1979-04-17 | |
HK578/81A HK57881A (en) | 1974-02-18 | 1981-11-26 | Piperidine derivatives |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB727874A GB1459506A (en) | 1974-02-18 | 1974-02-18 | Piperidine derivatives |
ZA00754726A ZA754726B (en) | 1974-02-18 | 1975-07-22 | Piperidine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1459506A true GB1459506A (en) | 1976-12-22 |
Family
ID=26241311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB727874A Expired GB1459506A (en) | 1974-02-18 | 1974-02-18 | Piperidine derivatives |
Country Status (12)
Country | Link |
---|---|
US (1) | US4073790A (en, 2012) |
JP (1) | JPS6031825B2 (en, 2012) |
BE (1) | BE825458A (en, 2012) |
CA (1) | CA1046065A (en, 2012) |
CH (3) | CH612937A5 (en, 2012) |
DE (1) | DE2505500A1 (en, 2012) |
FR (1) | FR2261008B1 (en, 2012) |
GB (1) | GB1459506A (en, 2012) |
HK (1) | HK57881A (en, 2012) |
IN (1) | IN140599B (en, 2012) |
NL (1) | NL7501913A (en, 2012) |
ZA (1) | ZA754726B (en, 2012) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4199590A (en) | 1977-09-08 | 1980-04-22 | John Wyeth & Brother Limited | Piperidino ureas and thioureas |
EP0157762B1 (fr) * | 1983-09-19 | 1990-08-08 | Bouchara S.A. | Nouvelles piperidinoguanidines substituees, leur procede de preparation et les compositions pharmaceutiques en renfermant |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1561023A (en) * | 1977-04-22 | 1980-02-13 | Beecham Group Ltd | 2-methoxy - 5 - chloro aniline derivatives |
US4281132A (en) * | 1977-10-29 | 1981-07-28 | John Wyeth & Brother Limited | Piperidino ureas and thioureas |
PL128510B1 (en) * | 1980-03-01 | 1984-02-29 | Wyeth John & Brother Ltd | Method of obtaining new piperidine derivatives |
US4806552A (en) * | 1980-03-01 | 1989-02-21 | John Wyeth & Brother, Limited | Pyridyl- and/or pyridoyl-(piperid-4-yl) ureas and analogues thereof |
US4722930A (en) * | 1980-03-01 | 1988-02-02 | John Wyeth And Brother Limited | 3-benzoyl-1-[(oxo or thioheteroaryl-ylalkyl)-piperid-4-yl]ureas and derivatives |
US4399286A (en) * | 1981-07-16 | 1983-08-16 | Mead Johnson & Company | Antiarrhythmic phenethylpiperidine compounds |
GB8528234D0 (en) * | 1985-11-15 | 1985-12-18 | Wyeth John & Brother Ltd | Heterocyclic compounds |
US6528529B1 (en) | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
KR20060120715A (ko) * | 1998-03-31 | 2006-11-27 | 아카디아 파마슈티칼스 인코포레이티드 | 무스카린 수용체에 대해 활성을 갖는 화합물 |
DE19952146A1 (de) * | 1999-10-29 | 2001-06-07 | Boehringer Ingelheim Pharma | Arylalkane, Arylalkene und Aryl-azaalkane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3238215A (en) * | 1963-10-17 | 1966-03-01 | Sterling Drug Inc | 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines |
GB1345872A (en) * | 1970-09-03 | 1974-02-06 | Wyeth John & Brother Ltd | Amino-and acylamino-pyridine and hydropyridine derivatives |
-
1974
- 1974-02-18 GB GB727874A patent/GB1459506A/en not_active Expired
-
1975
- 1975-02-10 DE DE19752505500 patent/DE2505500A1/de not_active Ceased
- 1975-02-11 CH CH413778A patent/CH612937A5/xx not_active IP Right Cessation
- 1975-02-11 CH CH161075A patent/CH613191A5/xx not_active IP Right Cessation
- 1975-02-12 US US05/549,271 patent/US4073790A/en not_active Expired - Lifetime
- 1975-02-12 BE BE153297A patent/BE825458A/xx not_active IP Right Cessation
- 1975-02-17 JP JP50019659A patent/JPS6031825B2/ja not_active Expired
- 1975-02-17 FR FR7504834A patent/FR2261008B1/fr not_active Expired
- 1975-02-18 NL NL7501913A patent/NL7501913A/xx not_active Application Discontinuation
- 1975-02-18 CA CA220,677A patent/CA1046065A/en not_active Expired
- 1975-07-22 ZA ZA00754726A patent/ZA754726B/xx unknown
- 1975-07-25 IN IN1449/CAL/75A patent/IN140599B/en unknown
-
1979
- 1979-04-17 CH CH360279A patent/CH615914A5/de not_active IP Right Cessation
-
1981
- 1981-11-26 HK HK578/81A patent/HK57881A/xx unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4199590A (en) | 1977-09-08 | 1980-04-22 | John Wyeth & Brother Limited | Piperidino ureas and thioureas |
EP0157762B1 (fr) * | 1983-09-19 | 1990-08-08 | Bouchara S.A. | Nouvelles piperidinoguanidines substituees, leur procede de preparation et les compositions pharmaceutiques en renfermant |
Also Published As
Publication number | Publication date |
---|---|
CA1046065A (en) | 1979-01-09 |
FR2261008A1 (en, 2012) | 1975-09-12 |
IN140599B (en, 2012) | 1976-12-04 |
DE2505500A1 (de) | 1975-08-21 |
CH615914A5 (en, 2012) | 1980-02-29 |
NL7501913A (nl) | 1975-08-20 |
CH612937A5 (en, 2012) | 1979-08-31 |
CH613191A5 (en, 2012) | 1979-09-14 |
JPS6031825B2 (ja) | 1985-07-24 |
HK57881A (en) | 1981-12-04 |
US4073790A (en) | 1978-02-14 |
FR2261008B1 (en, 2012) | 1978-07-21 |
ZA754726B (en) | 1976-06-30 |
BE825458A (fr) | 1975-08-12 |
JPS50116480A (en, 2012) | 1975-09-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1325192A (en) | Phloroglucinol derivatives | |
IE40378L (en) | 3-indolyl pyridyl ketones | |
SE7614201L (sv) | Sett att framstella ftalaner | |
GB1513824A (en) | 1,3,4,6,7,11b-hexahydro-2h-benzo(a)quinolizine derivative | |
GB1459506A (en) | Piperidine derivatives | |
GB1442118A (en) | Piperidine derivatives | |
GB1445967A (en) | Bispidine and bispidone derivatives | |
GB1266769A (en, 2012) | ||
IE35909L (en) | Acetoxylidides | |
IE820338L (en) | Azepines | |
IE40052L (en) | Piperidinoalkylindoles | |
GB1262965A (en) | Butyrophenones | |
GB1528723A (en) | 1-nitro-9-n-substituted aminoalkylamino-acridines their salts and a method of preparing same | |
GB1472467A (en) | Thiohydantoins | |
GB1457038A (en) | Amino derivatives of 1,4-benzodioxan | |
GB1382916A (en) | Derivatives of 3-2-1-piperazinyl-ethyl- indoline | |
GB1409648A (en) | Substituted pyrrolidinemethanol compounds and pharmaceutical compositions thereof | |
GB1498884A (en) | Aminoacetamide-pyridyl-tetrahydropyridyl and-piperidyl derivatives | |
GB1445765A (en) | Phenoxy-substituted malonic acid derivatives their prepration and pharmaceutical compositions containing them | |
GB1504707A (en) | 1-aryl-2-oxo-2,4,5,6,7,7a-hexahydroindoles | |
IE34993L (en) | Indenophthalazines | |
GB1316361A (en) | 5h-dibenzazepines | |
GB1310382A (en) | Process for the preparation of glucofuranosides | |
GB1213285A (en) | Substituted s-triazines | |
GB1318859A (en) | Imidazo-4,5-b-pyridine derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |