GB1456767A - Preparation of 7alpha-methoxy-cephalosporins and 6alpha-methoxy- penicillins - Google Patents
Preparation of 7alpha-methoxy-cephalosporins and 6alpha-methoxy- penicillinsInfo
- Publication number
- GB1456767A GB1456767A GB3639874A GB3639874A GB1456767A GB 1456767 A GB1456767 A GB 1456767A GB 3639874 A GB3639874 A GB 3639874A GB 3639874 A GB3639874 A GB 3639874A GB 1456767 A GB1456767 A GB 1456767A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methoxy
- optionally substituted
- aug
- 6alpha
- 7alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
1456767 7-α-Methoxycephalosporins and 6-α- methoxypenicillins MERCK & CO Inc 19 Aug 1974 [27 Aug 1973 31 May 1974] 36398/74 Heading C2C Compounds I and II in which X is H or a blocked OH, NH 2 or COOH radical, R is phenyl, tetrazolyl or 5-membered heterocyclic having 1 or 2 hetero atoms selected from N, O and S, A is H, optionally substituted tetrazolylthio, C 1-6 alkanoyloxy or optionally mono- or di-C 1-6 alkylated carbamoyloxy or thiocarbamoyloxy and M is H, Na, K benzyl optionally substituted by p-NO 2 , p-Br or p-MeO, benzhydryl, Me 3 Si, trichloroethyl, MeSCH 2 CH 2 , but-3-enyl, phenacyl p-bromophenacyl and in addition A is pyridinium optionally substituted by alkyl, halo or amino when COOM is a carboxyl anion; and their unblocked derivatives are prepared by reacting a Compound III or IV in which M<SP>1</SP> is as defined for M other than H, Na or K, with methanol in the presence of a Th(III), Bi(V) or Pb(IV) salt followed, if necessary by hydrolysis or salification.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39109973A | 1973-08-27 | 1973-08-27 | |
| US47448174A | 1974-05-31 | 1974-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1456767A true GB1456767A (en) | 1976-11-24 |
Family
ID=27013399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3639874A Expired GB1456767A (en) | 1973-08-27 | 1974-08-19 | Preparation of 7alpha-methoxy-cephalosporins and 6alpha-methoxy- penicillins |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5052084A (en) |
| CH (1) | CH606013A5 (en) |
| DD (1) | DD113010A5 (en) |
| DE (1) | DE2440790A1 (en) |
| DK (1) | DK417874A (en) |
| ES (1) | ES429285A1 (en) |
| FI (1) | FI230374A (en) |
| FR (1) | FR2270257B1 (en) |
| GB (1) | GB1456767A (en) |
| NL (1) | NL7410374A (en) |
| NO (1) | NO742850L (en) |
| SE (1) | SE7410181L (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104031070A (en) * | 2014-06-05 | 2014-09-10 | 苏州中联化学制药有限公司 | Synthesis method for cefminox sodium |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4165429A (en) * | 1976-06-28 | 1979-08-21 | Yamanouchi Pharmaceutical Co., Ltd. | 7α-METHOXY-CEPHALOSPORANIC ACID DERIVATIVES |
-
1974
- 1974-08-01 FI FI2303/74A patent/FI230374A/fi unknown
- 1974-08-01 NL NL7410374A patent/NL7410374A/en not_active Application Discontinuation
- 1974-08-06 DK DK417874A patent/DK417874A/da unknown
- 1974-08-08 SE SE7410181A patent/SE7410181L/xx unknown
- 1974-08-08 NO NO742850A patent/NO742850L/no unknown
- 1974-08-14 ES ES429285A patent/ES429285A1/en not_active Expired
- 1974-08-19 GB GB3639874A patent/GB1456767A/en not_active Expired
- 1974-08-20 CH CH1136774A patent/CH606013A5/xx not_active IP Right Cessation
- 1974-08-23 DD DD180691A patent/DD113010A5/xx unknown
- 1974-08-23 FR FR7428981A patent/FR2270257B1/fr not_active Expired
- 1974-08-26 DE DE2440790A patent/DE2440790A1/en not_active Withdrawn
- 1974-08-27 JP JP49097590A patent/JPS5052084A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104031070A (en) * | 2014-06-05 | 2014-09-10 | 苏州中联化学制药有限公司 | Synthesis method for cefminox sodium |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5052084A (en) | 1975-05-09 |
| DE2440790A1 (en) | 1975-03-13 |
| NL7410374A (en) | 1975-03-03 |
| FI230374A (en) | 1975-02-28 |
| FR2270257B1 (en) | 1979-08-03 |
| SE7410181L (en) | 1975-02-28 |
| DD113010A5 (en) | 1975-05-12 |
| ES429285A1 (en) | 1977-01-16 |
| CH606013A5 (en) | 1978-10-13 |
| DK417874A (en) | 1975-04-28 |
| FR2270257A1 (en) | 1975-12-05 |
| NO742850L (en) | 1975-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |