GB1455529A - - Google Patents

Info

Publication number
GB1455529A
GB1455529A GB818675A GB818675A GB1455529A GB 1455529 A GB1455529 A GB 1455529A GB 818675 A GB818675 A GB 818675A GB 818675 A GB818675 A GB 818675A GB 1455529 A GB1455529 A GB 1455529A
Authority
GB
United Kingdom
Prior art keywords
acid
mono
acid chloride
salts
thienylmalonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB818675A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to GB818675A priority Critical patent/GB1455529A/en
Priority to CA228,020A priority patent/CA1047484A/en
Priority to ZA757369A priority patent/ZA757369B/en
Priority to DE19752555158 priority patent/DE2555158A1/en
Priority to JP51011179A priority patent/JPS51101993A/ja
Priority to ES445577A priority patent/ES445577A1/en
Priority to AU11462/76A priority patent/AU1146276A/en
Priority to BE164751A priority patent/BE839058A/en
Publication of GB1455529A publication Critical patent/GB1455529A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1455529 Alpha - (p - tolyloxycarbonyl) - 3- thienylmethyl penicillin BEECHAM GROUP Ltd 27 Feb 1975 8186/75 Heading C2C The invention comprises the title compound and its non-toxic pharmaceutically acceptable salts, and a process for preparing it by reacting 6-aminopenicillanic acid with an acylating derivative (e.g. the acid chloride) of mono-p-tolyl 3-thienylmalonate. The latter is made from the mono-acid chloride of 3-thienylmalonic acid and p-cresol. Therapeutic and veterinary compositions in conventional form comprise the title compounds or its salts, which is active against grampositive and gram-negative bacteria and has a high degree of oral absorption in man.
GB818675A 1975-02-27 1975-02-27 Expired GB1455529A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
GB818675A GB1455529A (en) 1975-02-27 1975-02-27
CA228,020A CA1047484A (en) 1975-02-27 1975-05-29 Penicillins
ZA757369A ZA757369B (en) 1975-02-27 1975-11-24 Penicillins
DE19752555158 DE2555158A1 (en) 1975-02-27 1975-12-08 ALPHA- (TOLYLOXYCARBONYL) -3-THIENYLMETHYLPENICILLIN, METHOD OF ITS MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THIS COMPOUND
JP51011179A JPS51101993A (en) 1975-02-27 1976-02-04
ES445577A ES445577A1 (en) 1975-02-27 1976-02-26 A procedure for the preparation of alpha- (tolyloxycarbonyl) -3-tienylmetilpenicillin. (Machine-translation by Google Translate, not legally binding)
AU11462/76A AU1146276A (en) 1975-02-27 1976-02-26 Penicillins
BE164751A BE839058A (en) 1975-02-27 1976-02-27 PENICILLINS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB818675A GB1455529A (en) 1975-02-27 1975-02-27

Publications (1)

Publication Number Publication Date
GB1455529A true GB1455529A (en) 1976-11-10

Family

ID=9847499

Family Applications (1)

Application Number Title Priority Date Filing Date
GB818675A Expired GB1455529A (en) 1975-02-27 1975-02-27

Country Status (8)

Country Link
JP (1) JPS51101993A (en)
AU (1) AU1146276A (en)
BE (1) BE839058A (en)
CA (1) CA1047484A (en)
DE (1) DE2555158A1 (en)
ES (1) ES445577A1 (en)
GB (1) GB1455529A (en)
ZA (1) ZA757369B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0026644A1 (en) * 1979-10-02 1981-04-08 Beecham Group Plc Ortho-tolyl ester of an alpha-carboxy penicillin, process for its preparation and pharmaceutical compositions comprising the penicillin

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0026644A1 (en) * 1979-10-02 1981-04-08 Beecham Group Plc Ortho-tolyl ester of an alpha-carboxy penicillin, process for its preparation and pharmaceutical compositions comprising the penicillin
US4385060A (en) 1979-10-02 1983-05-24 Beecham Group Limited Penicillins

Also Published As

Publication number Publication date
DE2555158A1 (en) 1976-09-09
BE839058A (en) 1976-08-27
ZA757369B (en) 1976-11-24
AU1146276A (en) 1977-09-01
CA1047484A (en) 1979-01-30
JPS51101993A (en) 1976-09-08
ES445577A1 (en) 1977-11-01

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee