GB1453885A - Cyctopenla-j,k-phenanthren-4-yl alkanoic acids and their derivatives - Google Patents
Cyctopenla-j,k-phenanthren-4-yl alkanoic acids and their derivativesInfo
- Publication number
- GB1453885A GB1453885A GB1857874A GB1857874A GB1453885A GB 1453885 A GB1453885 A GB 1453885A GB 1857874 A GB1857874 A GB 1857874A GB 1857874 A GB1857874 A GB 1857874A GB 1453885 A GB1453885 A GB 1453885A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrogen
- prepared
- alkyl
- iodo
- acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 6
- 150000007513 acids Chemical class 0.000 title abstract 3
- -1 mercapto, hydroxy Chemical group 0.000 abstract 15
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000004414 alkyl thio group Chemical group 0.000 abstract 3
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- WWKKTHALZAYYAI-UHFFFAOYSA-N 2-iodobenzaldehyde Chemical class IC1=CC=CC=C1C=O WWKKTHALZAYYAI-UHFFFAOYSA-N 0.000 abstract 2
- ULAUMFDMSJNKHA-UHFFFAOYSA-N 4-iodo-2,3-dihydroinden-1-one Chemical compound IC1=CC=CC2=C1CCC2=O ULAUMFDMSJNKHA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 150000008064 anhydrides Chemical class 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 238000006193 diazotization reaction Methods 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- JKBNIGORIGTVNA-UHFFFAOYSA-N 2-(4-iodo-3H-inden-1-yl)propanoic acid Chemical class IC=1C=CC=C2C(=CCC=12)C(C(=O)O)C JKBNIGORIGTVNA-UHFFFAOYSA-N 0.000 abstract 1
- CJNZAXGUTKBIHP-UHFFFAOYSA-N 2-iodobenzoic acid Chemical compound OC(=O)C1=CC=CC=C1I CJNZAXGUTKBIHP-UHFFFAOYSA-N 0.000 abstract 1
- 150000005341 2-nitrobenzoic acids Chemical class 0.000 abstract 1
- VDIKJTUGYIOQTP-UHFFFAOYSA-N 4-methylsulfanyl-2-nitrobenzoic acid Chemical compound CSC1=CC=C(C(O)=O)C([N+]([O-])=O)=C1 VDIKJTUGYIOQTP-UHFFFAOYSA-N 0.000 abstract 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 abstract 1
- BQIKRTGTPBOIMK-UHFFFAOYSA-N [O]C[O] Chemical compound [O]C[O] BQIKRTGTPBOIMK-UHFFFAOYSA-N 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000005136 alkenylsulfinyl group Chemical group 0.000 abstract 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000005122 aminoalkylamino group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- KDPAWGWELVVRCH-UHFFFAOYSA-M bromoacetate Chemical compound [O-]C(=O)CBr KDPAWGWELVVRCH-UHFFFAOYSA-M 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000005191 hydroxyalkylamino group Chemical group 0.000 abstract 1
- QNXSIUBBGPHDDE-UHFFFAOYSA-N indan-1-one Chemical compound C1=CC=C2C(=O)CCC2=C1 QNXSIUBBGPHDDE-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 238000006396 nitration reaction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
- C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
- C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Rheumatology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US357314A US3867433A (en) | 1973-05-04 | 1973-05-04 | Cyclopenta{8 j,k{9 -phenanthrene-4-acetic acids and related compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1453885A true GB1453885A (en) | 1976-10-27 |
Family
ID=23405100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1857874A Expired GB1453885A (en) | 1973-05-04 | 1974-04-29 | Cyctopenla-j,k-phenanthren-4-yl alkanoic acids and their derivatives |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3867433A (enrdf_load_stackoverflow) |
| JP (1) | JPS5013371A (enrdf_load_stackoverflow) |
| CH (1) | CH592597A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2421541A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2236488B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1453885A (enrdf_load_stackoverflow) |
| NL (1) | NL7405118A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6777575B2 (en) | 1997-07-07 | 2004-08-17 | Rhone-Poulenc Agro | Process for the preparation of 2-alkylthio benzoic acid derivatives |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4704467A (en) * | 1986-12-12 | 1987-11-03 | Stauffer Chemical Company | Method for preparation of mercaptobenzoates |
| MX168606B (es) * | 1986-12-12 | 1993-06-01 | Ici American Ine | Metodo para la preparacion de mercaptobenzoatos. |
| US4692545A (en) * | 1986-12-12 | 1987-09-08 | Stauffer Chemical Company | Method for preparation of mercaptobenzoates |
| US6180629B1 (en) | 1998-08-14 | 2001-01-30 | Cell Pathways, Inc. | [4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB330916A (en) * | 1929-02-01 | 1930-06-19 | Ig Farbenindustrie Ag | Manufacture of aryl-acetic acids and substitution products thereof |
| US3766259A (en) * | 1970-05-01 | 1973-10-16 | Merck & Co Inc | Preparation of 1-aryl-3-indenyl acetic acids |
| US3654349A (en) * | 1970-05-01 | 1972-04-04 | Merck & Co Inc | Substituted indenyl acetic acids |
-
1973
- 1973-05-04 US US357314A patent/US3867433A/en not_active Expired - Lifetime
-
1974
- 1974-04-16 NL NL7405118A patent/NL7405118A/xx not_active Application Discontinuation
- 1974-04-26 CH CH576874A patent/CH592597A5/xx not_active IP Right Cessation
- 1974-04-29 GB GB1857874A patent/GB1453885A/en not_active Expired
- 1974-05-02 FR FR7415225A patent/FR2236488B1/fr not_active Expired
- 1974-05-02 JP JP49048871A patent/JPS5013371A/ja active Pending
- 1974-05-03 DE DE2421541A patent/DE2421541A1/de not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6777575B2 (en) | 1997-07-07 | 2004-08-17 | Rhone-Poulenc Agro | Process for the preparation of 2-alkylthio benzoic acid derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| CH592597A5 (enrdf_load_stackoverflow) | 1977-10-31 |
| NL7405118A (enrdf_load_stackoverflow) | 1974-11-06 |
| FR2236488A1 (enrdf_load_stackoverflow) | 1975-02-07 |
| JPS5013371A (enrdf_load_stackoverflow) | 1975-02-12 |
| DE2421541A1 (de) | 1974-11-21 |
| US3867433A (en) | 1975-02-18 |
| FR2236488B1 (enrdf_load_stackoverflow) | 1978-02-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1038725A (en) | Substituted indanes and indenes | |
| GB1254908A (en) | Indanyloxy and indanylthio alkanoic acids and derivatives | |
| GB1369543A (en) | Indenylalkanoic acid compounds | |
| GB1286918A (en) | Indene derivatives, their preparation and compositions containing them | |
| GB1453885A (en) | Cyctopenla-j,k-phenanthren-4-yl alkanoic acids and their derivatives | |
| GB1369542A (en) | Substituted indenylalkanoic acids | |
| JPS5587771A (en) | 1-phenylisoquinoline derivative | |
| US5200550A (en) | Bi-aromatic esters, a process for their preparation and their use in human or veterinary medicine and in cosmetic compositions | |
| GB1467110A (en) | 4-phenyl-5-oxo-heptenoic acids | |
| GB1176854A (en) | Substituted-3,4-Dihydroquinazolines and method fo preparation | |
| GB1268465A (en) | Substituted salicylic acid compounds | |
| GB1312391A (en) | Basically substituted 4 3h- quinazolinone derivatives and process for their manufacture | |
| GB1455524A (en) | Aryl-substituted oxo-alkanoic and oxo-alkenoic acids and derivatives of such acids | |
| GB1408964A (en) | 1-aralkyl-indenyl-3-acetic acids methods for their preparation and compositions containing them | |
| GB1453894A (en) | Tetrahydrofluorene and trimethanoindene compounds | |
| GB1370028A (en) | Substituted indenyl acetic acid derivatives | |
| US3660403A (en) | Halophenylpyrimidine carboxylic acids | |
| IE34425B1 (en) | Substituted indenylacetic acids and their derivatives | |
| GB1455739A (en) | Acid amides | |
| GB1251142A (enrdf_load_stackoverflow) | ||
| GB1209799A (en) | Aminoalkylbicyclocarboxylic acids | |
| GB1175212A (en) | Halo-Substituted 5-Phenylbenzoic Acids and their Derivatives | |
| IL75162A (en) | Process for the preparation of 3-(1h-tetrazol-4-yl)-4(3h)-quinazolinones and some intermediates therefor | |
| GB1263768A (en) | New substituted aryloxy- and arylthioacetic acids, esters and salts thereof, process for their production and compositions containing same | |
| GB1461456A (en) | 1-acetoxy-2-2-acetoxyethyl-cyclopent-1-ene |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |