GB1453583A - Digoxin derivatives - Google Patents
Digoxin derivativesInfo
- Publication number
- GB1453583A GB1453583A GB800775A GB800775A GB1453583A GB 1453583 A GB1453583 A GB 1453583A GB 800775 A GB800775 A GB 800775A GB 800775 A GB800775 A GB 800775A GB 1453583 A GB1453583 A GB 1453583A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl ester
- tyrosine methyl
- digoxin derivatives
- reaction
- digoxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical class C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 title 1
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- MYTOTTSMVMWVJN-STQMWFEESA-N Lys-Tyr Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 MYTOTTSMVMWVJN-STQMWFEESA-N 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000011521 glass Substances 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- MWZPENIJLUWBSY-VIFPVBQESA-N methyl L-tyrosinate Chemical compound COC(=O)[C@@H](N)CC1=CC=C(O)C=C1 MWZPENIJLUWBSY-VIFPVBQESA-N 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US447249A US3925355A (en) | 1974-03-01 | 1974-03-01 | Labelled digoxin derivatives for radioimmunoassay |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1453583A true GB1453583A (en) | 1976-10-27 |
Family
ID=23775584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB800775A Expired GB1453583A (en) | 1974-03-01 | 1975-02-26 | Digoxin derivatives |
Country Status (6)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4184037A (en) * | 1973-06-21 | 1980-01-15 | Burroughs Wellcome Co. | Digoxin oxidized product |
| GB1471755A (en) * | 1974-06-20 | 1977-04-27 | Radiochemical Centre Ltd | Derivatives of digoxin and digotoxin |
| US4064227A (en) * | 1975-03-17 | 1977-12-20 | Mallinckrodt, Inc. | Radioimmunoassay method for the determination of cardiotonic glycosides |
| US4336185A (en) * | 1976-03-02 | 1982-06-22 | Rohm And Haas Company | Folic acid derivatives |
| US4056608A (en) * | 1976-04-08 | 1977-11-01 | Syva Company | Cardiac glycoside or aglycone assays |
| US4202874A (en) * | 1976-09-29 | 1980-05-13 | Becton Dickinson & Company | Monoradioiodinated derivatives and precursors for production thereon |
| US4221725A (en) * | 1977-08-12 | 1980-09-09 | E. R. Squibb & Sons, Inc. | Steroid derivatives and their use in radioimmunoassays |
| US4230621A (en) * | 1978-05-01 | 1980-10-28 | E. R. Squibb & Sons, Inc. | Steroid derivatives and their use in radioimmunoassays |
| US4345096A (en) * | 1979-01-17 | 1982-08-17 | E. R. Squibb & Sons, Inc. | Steroid derivatives and their use in radioimmunoassays |
| US4595656A (en) * | 1984-01-06 | 1986-06-17 | Becton Dickinson & Company | Coupling agents and products produced therefrom |
| US4670406A (en) * | 1984-01-06 | 1987-06-02 | Becton Dickinson And Company | Tracers for use in assays |
| US5104637A (en) * | 1985-02-06 | 1992-04-14 | University Of Cincinnati | Radio labeled dihematophorphyrin ether and its use in detecting and treating neoplastic tissue |
| DE3802060A1 (de) * | 1988-01-25 | 1989-07-27 | Boehringer Mannheim Gmbh | Hapten-protein-konjugate und ihre verwendung |
| DE3836656A1 (de) * | 1988-10-27 | 1990-05-03 | Boehringer Mannheim Gmbh | Neue digoxigenin-derivate und ihre verwendung |
| FR2836996A1 (fr) * | 2002-03-05 | 2003-09-12 | Centre Nat Rech Scient | PRECURSEURS DE TRACEURS IMMUNOLOGIQUES NON-PEPTIDIQUES COMPRENANT UN MOTIF TYROSYL-(X)n-LYSINE-(X)n-TYROSINE, PROCEDE DE PREPARATION ET LEURS APPLICATIONS |
| GB0228936D0 (en) * | 2002-12-12 | 2003-01-15 | Bio Med Reagents Ltd | "Labelled compounds |
| WO2015029035A1 (en) | 2013-08-29 | 2015-03-05 | Yeda Research And Development Co. Ltd. | SELECTIVE INHIBITORS OF α2 ISOFORM OF Na,K-ATPase AND USE FOR REDUCTION OF INTRA-OCULAR PRESSURE |
| WO2017013637A1 (en) * | 2015-07-19 | 2017-01-26 | Yeda Research And Development Co. Ltd. | Selective inhibitors of alpha2-containing isoforms of na,k-atpase and use thereof for reduction of intraocular pressure |
| US10668094B2 (en) | 2015-07-19 | 2020-06-02 | Yeda Research And Development Co. Ltd. | Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2885394A (en) * | 1956-12-11 | 1959-05-05 | Lasdon Foundation Inc | Modified saccharide compounds |
| US3014026A (en) * | 1958-09-05 | 1961-12-19 | Kroll Harry | Chelates of monosaccharide-amino acids and related compounds |
-
1974
- 1974-03-01 US US447249A patent/US3925355A/en not_active Expired - Lifetime
-
1975
- 1975-02-07 DE DE19752505267 patent/DE2505267A1/de not_active Withdrawn
- 1975-02-26 GB GB800775A patent/GB1453583A/en not_active Expired
- 1975-02-27 FR FR7506110A patent/FR2262670B1/fr not_active Expired
- 1975-02-27 JP JP50024478A patent/JPS50117766A/ja active Pending
- 1975-02-28 CA CA221,002A patent/CA1051870A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2505267A1 (de) | 1975-09-04 |
| FR2262670B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1978-04-21 |
| CA1051870A (en) | 1979-04-03 |
| US3925355A (en) | 1975-12-09 |
| JPS50117766A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-09-16 |
| FR2262670A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-09-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] |