GB1453583A - Digoxin derivatives - Google Patents

Digoxin derivatives

Info

Publication number
GB1453583A
GB1453583A GB800775A GB800775A GB1453583A GB 1453583 A GB1453583 A GB 1453583A GB 800775 A GB800775 A GB 800775A GB 800775 A GB800775 A GB 800775A GB 1453583 A GB1453583 A GB 1453583A
Authority
GB
United Kingdom
Prior art keywords
methyl ester
tyrosine methyl
digoxin derivatives
reaction
digoxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB800775A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corning Glass Works
Original Assignee
Corning Glass Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corning Glass Works filed Critical Corning Glass Works
Publication of GB1453583A publication Critical patent/GB1453583A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

1453583 Dipeptide CORNING GLASS WORKS 26 Feb 1975 [1 March 1974] 8007/75 Heading C3H [Also in Divisions C2 and G1] L-lysyl-L-tyrosine methyl ester is prepared by the reaction of L-tyrosine methyl ester with N<SP>α</SP> - (tert - butoxycarbonyl) - N<SP>#</SP> - (benzyloxycarbonyl) - L - lysine p - nitrophenyl ester, and hydrolysing the reaction product. Per se compounds of formula wherein R 1 , R 2 are H or <SP>125</SP>I.
GB800775A 1974-03-01 1975-02-26 Digoxin derivatives Expired GB1453583A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US447249A US3925355A (en) 1974-03-01 1974-03-01 Labelled digoxin derivatives for radioimmunoassay

Publications (1)

Publication Number Publication Date
GB1453583A true GB1453583A (en) 1976-10-27

Family

ID=23775584

Family Applications (1)

Application Number Title Priority Date Filing Date
GB800775A Expired GB1453583A (en) 1974-03-01 1975-02-26 Digoxin derivatives

Country Status (6)

Country Link
US (1) US3925355A (en)
JP (1) JPS50117766A (en)
CA (1) CA1051870A (en)
DE (1) DE2505267A1 (en)
FR (1) FR2262670B1 (en)
GB (1) GB1453583A (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4184037A (en) * 1973-06-21 1980-01-15 Burroughs Wellcome Co. Digoxin oxidized product
GB1471755A (en) * 1974-06-20 1977-04-27 Radiochemical Centre Ltd Derivatives of digoxin and digotoxin
US4064227A (en) * 1975-03-17 1977-12-20 Mallinckrodt, Inc. Radioimmunoassay method for the determination of cardiotonic glycosides
US4336185A (en) * 1976-03-02 1982-06-22 Rohm And Haas Company Folic acid derivatives
US4056608A (en) * 1976-04-08 1977-11-01 Syva Company Cardiac glycoside or aglycone assays
US4202874A (en) * 1976-09-29 1980-05-13 Becton Dickinson & Company Monoradioiodinated derivatives and precursors for production thereon
US4230621A (en) * 1978-05-01 1980-10-28 E. R. Squibb & Sons, Inc. Steroid derivatives and their use in radioimmunoassays
US4221725A (en) * 1977-08-12 1980-09-09 E. R. Squibb & Sons, Inc. Steroid derivatives and their use in radioimmunoassays
US4345096A (en) * 1979-01-17 1982-08-17 E. R. Squibb & Sons, Inc. Steroid derivatives and their use in radioimmunoassays
US4670406A (en) * 1984-01-06 1987-06-02 Becton Dickinson And Company Tracers for use in assays
US4595656A (en) * 1984-01-06 1986-06-17 Becton Dickinson & Company Coupling agents and products produced therefrom
US5104637A (en) * 1985-02-06 1992-04-14 University Of Cincinnati Radio labeled dihematophorphyrin ether and its use in detecting and treating neoplastic tissue
DE3802060A1 (en) * 1988-01-25 1989-07-27 Boehringer Mannheim Gmbh HAPTEN-PROTEIN CONJUGATES AND THEIR USE
DE3836656A1 (en) * 1988-10-27 1990-05-03 Boehringer Mannheim Gmbh NEW DIGOXIGENINE DERIVATIVES AND THEIR USE
FR2836996A1 (en) * 2002-03-05 2003-09-12 Centre Nat Rech Scient NON-PEPTIDE IMMUNOLOGIC TRACER PRECURSORS COMPRISING TYROSYL- (X) n-LYSINE- (X) n-TYROSINE PATTERN, PREPARATION METHOD AND APPLICATIONS THEREOF
GB0228936D0 (en) * 2002-12-12 2003-01-15 Bio Med Reagents Ltd "Labelled compounds
EP3039030B1 (en) 2013-08-29 2018-09-19 Yeda Research and Development Co. Ltd. Selective inhibitors of alpha2 isoform of na,k-atpase and use for reduction of intra-ocular pressure
WO2017013637A1 (en) * 2015-07-19 2017-01-26 Yeda Research And Development Co. Ltd. Selective inhibitors of alpha2-containing isoforms of na,k-atpase and use thereof for reduction of intraocular pressure
EP3325494B1 (en) 2015-07-19 2020-12-30 Yeda Research and Development Co., Ltd. Selective inhibitors of alpha2-containing isoforms of na,k-atpase and use thereof for reducing intraocular pressure

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2885394A (en) * 1956-12-11 1959-05-05 Lasdon Foundation Inc Modified saccharide compounds
US3014026A (en) * 1958-09-05 1961-12-19 Kroll Harry Chelates of monosaccharide-amino acids and related compounds

Also Published As

Publication number Publication date
FR2262670A1 (en) 1975-09-26
FR2262670B1 (en) 1978-04-21
JPS50117766A (en) 1975-09-16
CA1051870A (en) 1979-04-03
US3925355A (en) 1975-12-09
DE2505267A1 (en) 1975-09-04

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]