GB1451480A - Processes for the preparation os substituted phenylguanidines and the compounds thus prepared - Google Patents
Processes for the preparation os substituted phenylguanidines and the compounds thus preparedInfo
- Publication number
- GB1451480A GB1451480A GB2499276A GB2499276A GB1451480A GB 1451480 A GB1451480 A GB 1451480A GB 2499276 A GB2499276 A GB 2499276A GB 2499276 A GB2499276 A GB 2499276A GB 1451480 A GB1451480 A GB 1451480A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- processes
- prepared
- preparation
- phenylguanidines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QRJZGVVKGFIGLI-UHFFFAOYSA-N 2-phenylguanidine Chemical class NC(=N)NC1=CC=CC=C1 QRJZGVVKGFIGLI-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 abstract 1
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 150000001448 anilines Chemical class 0.000 abstract 1
- 229930003836 cresol Natural products 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000002256 xylenyl group Chemical class C1(C(C=CC=C1)C)(C)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29147472A | 1972-09-22 | 1972-09-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1451480A true GB1451480A (en) | 1976-10-06 |
Family
ID=23120445
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2499276A Expired GB1451480A (en) | 1972-09-22 | 1973-09-24 | Processes for the preparation os substituted phenylguanidines and the compounds thus prepared |
| GB3221175A Expired GB1451478A (en) | 1972-09-22 | 1973-09-24 | Phenylguanidine derivatives and processes for their preparation |
| GB4465473A Expired GB1451477A (en) | 1972-09-22 | 1973-09-24 | Phenylamidinourea derivatives processes for their preparation and compositions incorporating them |
| GB2491476A Expired GB1451479A (en) | 1972-09-22 | 1973-09-24 | Phenylamidourea derivatives and processes for their preparation |
| GB23574/75A Expired GB1514198A (en) | 1972-09-22 | 1975-05-30 | Substituted phenylguanidine compounds processes for their preparation and pharmaceutical compositions containing the same |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3221175A Expired GB1451478A (en) | 1972-09-22 | 1973-09-24 | Phenylguanidine derivatives and processes for their preparation |
| GB4465473A Expired GB1451477A (en) | 1972-09-22 | 1973-09-24 | Phenylamidinourea derivatives processes for their preparation and compositions incorporating them |
| GB2491476A Expired GB1451479A (en) | 1972-09-22 | 1973-09-24 | Phenylamidourea derivatives and processes for their preparation |
| GB23574/75A Expired GB1514198A (en) | 1972-09-22 | 1975-05-30 | Substituted phenylguanidine compounds processes for their preparation and pharmaceutical compositions containing the same |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS593471B2 (enExample) |
| AR (1) | AR200024A1 (enExample) |
| BE (1) | BE805138A (enExample) |
| CA (1) | CA1041908A (enExample) |
| CH (2) | CH614430A5 (enExample) |
| DE (1) | DE2345951C2 (enExample) |
| ES (1) | ES418987A1 (enExample) |
| FR (1) | FR2200002B1 (enExample) |
| GB (5) | GB1451480A (enExample) |
| IL (1) | IL43280A (enExample) |
| NL (1) | NL7313040A (enExample) |
| PH (1) | PH12016A (enExample) |
| SE (2) | SE416952B (enExample) |
| ZA (1) | ZA737475B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4025652A (en) * | 1975-03-31 | 1977-05-24 | William H. Rorer, Inc. | Amidinoureas |
| US4220658A (en) * | 1972-09-22 | 1980-09-02 | William H. Rorer, Inc. | Treatment of hypertension with amidinoureas |
| US4488993A (en) * | 1972-09-22 | 1984-12-18 | William H. Rorer, Inc. | Amidinoureas |
| US4326074A (en) | 1972-09-22 | 1982-04-20 | William H. Rorer, Inc. | Amidinoureas |
| US4713382A (en) * | 1985-05-30 | 1987-12-15 | Syntex (U.S.A.) Inc. | N-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrhythmic agents |
| ATE157351T1 (de) * | 1993-02-20 | 1997-09-15 | Hoechst Ag | Substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament, als inhibitoren des zellulären na+/h+-austauschs oder als diagnostikum sowie sie enthaltendes medikament |
| RU2156759C1 (ru) * | 2000-01-24 | 2000-09-27 | Совместное предприятие Закрытое акционерное общество "Пронова" | Способ получения n, n'-дифенилгуанидина |
-
1973
- 1973-09-10 PH PH15001A patent/PH12016A/en unknown
- 1973-09-12 DE DE2345951A patent/DE2345951C2/de not_active Expired
- 1973-09-13 CA CA181,015A patent/CA1041908A/en not_active Expired
- 1973-09-17 CH CH1605977A patent/CH614430A5/xx not_active IP Right Cessation
- 1973-09-17 CH CH1330773A patent/CH605703A5/xx not_active IP Right Cessation
- 1973-09-20 AR AR250179A patent/AR200024A1/es active
- 1973-09-21 NL NL7313040A patent/NL7313040A/xx not_active Application Discontinuation
- 1973-09-21 IL IL43280A patent/IL43280A/en unknown
- 1973-09-21 ZA ZA737475A patent/ZA737475B/xx unknown
- 1973-09-21 JP JP48107418A patent/JPS593471B2/ja not_active Expired
- 1973-09-21 BE BE135886A patent/BE805138A/xx not_active IP Right Cessation
- 1973-09-21 FR FR7333963A patent/FR2200002B1/fr not_active Expired
- 1973-09-21 SE SE7312880A patent/SE416952B/xx unknown
- 1973-09-21 ES ES418987A patent/ES418987A1/es not_active Expired
- 1973-09-24 GB GB2499276A patent/GB1451480A/en not_active Expired
- 1973-09-24 GB GB3221175A patent/GB1451478A/en not_active Expired
- 1973-09-24 GB GB4465473A patent/GB1451477A/en not_active Expired
- 1973-09-24 GB GB2491476A patent/GB1451479A/en not_active Expired
-
1975
- 1975-05-30 GB GB23574/75A patent/GB1514198A/en not_active Expired
-
1976
- 1976-11-02 SE SE7612176A patent/SE416953B/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB1451478A (en) | 1976-10-06 |
| GB1451479A (en) | 1976-10-06 |
| GB1514198A (en) | 1978-06-14 |
| IL43280A (en) | 1977-06-30 |
| FR2200002B1 (enExample) | 1977-07-15 |
| GB1451477A (en) | 1976-10-06 |
| DE2345951A1 (de) | 1974-04-04 |
| ES418987A1 (es) | 1976-07-01 |
| CA1041908A (en) | 1978-11-07 |
| JPS4985046A (enExample) | 1974-08-15 |
| JPS593471B2 (ja) | 1984-01-24 |
| SE416953B (sv) | 1981-02-16 |
| BE805138A (fr) | 1974-01-16 |
| IL43280A0 (en) | 1973-11-28 |
| CH605703A5 (enExample) | 1978-10-13 |
| SE7612176L (sv) | 1976-11-02 |
| ZA737475B (en) | 1974-10-30 |
| CH614430A5 (en) | 1979-11-30 |
| AR200024A1 (es) | 1974-10-15 |
| NL7313040A (enExample) | 1974-03-26 |
| DE2345951C2 (de) | 1986-10-23 |
| FR2200002A1 (enExample) | 1974-04-19 |
| SE416952B (sv) | 1981-02-16 |
| PH12016A (en) | 1978-10-06 |
| AU6047973A (en) | 1975-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |