GB1448458A - 1,3-dioxan derivatives and pharmaceutical compositions thereof - Google Patents
1,3-dioxan derivatives and pharmaceutical compositions thereofInfo
- Publication number
- GB1448458A GB1448458A GB5392473A GB5392473A GB1448458A GB 1448458 A GB1448458 A GB 1448458A GB 5392473 A GB5392473 A GB 5392473A GB 5392473 A GB5392473 A GB 5392473A GB 1448458 A GB1448458 A GB 1448458A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- formula
- choh
- compound
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- VDFVNEFVBPFDSB-UHFFFAOYSA-N 1,3-dioxane Chemical class C1COCOC1 VDFVNEFVBPFDSB-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 8
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- ZPVFWPFBNIEHGJ-UHFFFAOYSA-N 2-octanone Chemical compound CCCCCCC(C)=O ZPVFWPFBNIEHGJ-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- -1 methylenedioxy Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- BIECKCJPCYPAMM-UHFFFAOYSA-N 3,3-bis(hydroxymethyl)octan-2-one Chemical compound CCCCCC(CO)(CO)C(C)=O BIECKCJPCYPAMM-UHFFFAOYSA-N 0.000 abstract 1
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/75—Reactions with formaldehyde
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/17—Saturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5392473A GB1448458A (en) | 1973-11-21 | 1973-11-21 | 1,3-dioxan derivatives and pharmaceutical compositions thereof |
| IE2289/74A IE40539B1 (en) | 1973-11-21 | 1974-11-07 | 1,3-dioxan derivatives and pharmaceutical compositions theeof |
| ZA00747219A ZA747219B (en) | 1973-11-21 | 1974-11-11 | Pharmaceutical compositions containing heterocyclic compounds |
| US05/523,238 US4085222A (en) | 1973-11-21 | 1974-11-12 | Pharmaceutical compositions containing 1,3-dioxanes |
| AU75364/74A AU479172B2 (en) | 1973-11-21 | 1974-11-14 | l, 3-DIOXANS |
| DE19742454281 DE2454281A1 (de) | 1973-11-21 | 1974-11-15 | Neue 1,3-dioxane, verfahren zu ihrer herstellung und diese enthaltende mittel |
| CH1534474A CH617194A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-11-21 | 1974-11-18 | |
| BE150636A BE822345A (fr) | 1973-11-21 | 1974-11-19 | Nouveaux 1 |
| SE7414595A SE407575B (sv) | 1973-11-21 | 1974-11-20 | Forfarande for framstellning av 1,3-dioxanderivat med terapentisk verkan |
| DK604574A DK604574A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-11-21 | 1974-11-20 | |
| FR7438124A FR2251324B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-11-21 | 1974-11-20 | |
| JP49135057A JPS5083377A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-11-21 | 1974-11-21 | |
| NL7415163A NL7415163A (nl) | 1973-11-21 | 1974-11-21 | Werkwijze ter bereiding van een geneesmiddel met analgetische werking. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5392473A GB1448458A (en) | 1973-11-21 | 1973-11-21 | 1,3-dioxan derivatives and pharmaceutical compositions thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1448458A true GB1448458A (en) | 1976-09-08 |
Family
ID=10469419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5392473A Expired GB1448458A (en) | 1973-11-21 | 1973-11-21 | 1,3-dioxan derivatives and pharmaceutical compositions thereof |
Country Status (12)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5175143A (en) * | 1987-01-29 | 1992-12-29 | Unilever Patent Holdings B.V. | Perfumery materials |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4322354A (en) * | 1979-03-05 | 1982-03-30 | Timex Corporation | 5-Substituted-2-(4-cyanophenyl)-1,3,-dioxanes |
| US4298528A (en) * | 1980-03-28 | 1981-11-03 | Timex Corporation | Cyclohexyl-dioxane liquid crystalline compounds |
| US4313878A (en) * | 1980-12-03 | 1982-02-02 | Timex Corporation | 4-Substituted phenyl 4'-(5-n-alkyl-1,3-dioxan-2-yl)benzoates |
| US4325830A (en) * | 1980-12-24 | 1982-04-20 | Timex Corporation | Three ring dioxane liquid crystalline compounds |
| DE3119201A1 (de) * | 1981-05-14 | 1982-12-09 | Basf Ag, 6700 Ludwigshafen | Substituierte 1,3-dioxane, verfahren zu ihrer herstellung, diese enthaltende herbizide und ihre anwendung als herbizide |
| JPS6036479A (ja) * | 1983-08-08 | 1985-02-25 | Kotobuki Seiyaku Kk | １，３−ジオキサン誘導体、本化合物を有効成分とする抗潰瘍剤及びその製造方法 |
| GB8531892D0 (en) * | 1985-12-30 | 1986-02-05 | Ici Plc | Carboxylic acids |
| US4861764A (en) * | 1986-11-17 | 1989-08-29 | Macro Chem. Corp. | Percutaneous absorption enhancers, compositions containing same and method of use |
| US5292763A (en) * | 1989-11-03 | 1994-03-08 | Rohm And Haas Company | Synergistic microbicidal combinations containing 4,5-dichloro-2-octyl-3-isothiazolone and certain commercial biocides |
| US5468759A (en) * | 1991-12-19 | 1995-11-21 | Rohm And Haas Company | Synergistic microbicidal combinations containing 4,5-dichloro-2-octyl-3-isothiazolone and certain commercial biocides |
| US5620980A (en) * | 1995-02-22 | 1997-04-15 | Macrochem Corporation | Method for treating hair loss |
| US5728848A (en) * | 1996-03-11 | 1998-03-17 | Council Of Scientific & Industrial Research | 9-hydroxymethyl-7,12 dioxaspiro 5,6!dodecane, novel 9-(2-hydroxyethyl-7,11-dioxaspiro 5,5!undecane and a process for preparing said 9-(2-hydroxyethyl-7,11 dioxaspiro 5,5!undecane |
| US8324407B2 (en) | 2009-01-30 | 2012-12-04 | Mitsubishi Gas Chemical Company, Inc. | Alcohol compound having dioxane structure and process for producing same |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA475546A (en) * | 1951-07-24 | Standard Oil Development Company | Metadioxanes produced from aldehydes and olefinic compounds | |
| US3000905A (en) * | 1959-01-02 | 1961-09-19 | Atlantic Refining Co | Production of hydroxymethyl-dimethyl-meta-dioxanes |
| US3454596A (en) * | 1964-06-03 | 1969-07-08 | Mobil Oil Corp | Addition reactions to carbonyl compounds |
| JPS4320012Y1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1965-05-26 | 1968-08-22 | ||
| SE323391B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1967-01-25 | 1970-05-04 | Perstorp Ab | |
| DE1905258A1 (de) * | 1969-02-04 | 1970-08-06 | Dynamit Nobel Ag | Ketonitrile und Verfahren zu deren Herstellung |
| IT988012B (it) * | 1970-03-25 | 1975-04-10 | Dynamit Nobel Ag | Procedimento per la produzione di acetali ciclici di benzofenone |
| FR2121459B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1971-01-08 | 1973-11-30 | Pepro | |
| GB1401978A (en) * | 1971-11-29 | 1975-08-06 | Shell Int Research | Substituted cyclic 1,3-diethers and their use as herbicides |
-
1973
- 1973-11-21 GB GB5392473A patent/GB1448458A/en not_active Expired
-
1974
- 1974-11-07 IE IE2289/74A patent/IE40539B1/xx unknown
- 1974-11-11 ZA ZA00747219A patent/ZA747219B/xx unknown
- 1974-11-12 US US05/523,238 patent/US4085222A/en not_active Expired - Lifetime
- 1974-11-15 DE DE19742454281 patent/DE2454281A1/de not_active Withdrawn
- 1974-11-18 CH CH1534474A patent/CH617194A5/de not_active IP Right Cessation
- 1974-11-19 BE BE150636A patent/BE822345A/xx unknown
- 1974-11-20 FR FR7438124A patent/FR2251324B1/fr not_active Expired
- 1974-11-20 DK DK604574A patent/DK604574A/da unknown
- 1974-11-20 SE SE7414595A patent/SE407575B/xx unknown
- 1974-11-21 NL NL7415163A patent/NL7415163A/xx not_active Application Discontinuation
- 1974-11-21 JP JP49135057A patent/JPS5083377A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5175143A (en) * | 1987-01-29 | 1992-12-29 | Unilever Patent Holdings B.V. | Perfumery materials |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA747219B (en) | 1975-11-26 |
| SE407575B (sv) | 1979-04-02 |
| BE822345A (fr) | 1975-05-20 |
| FR2251324B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1978-06-30 |
| DE2454281A1 (de) | 1975-05-22 |
| SE7414595L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-05-22 |
| IE40539L (en) | 1975-05-21 |
| US4085222A (en) | 1978-04-18 |
| AU7536474A (en) | 1976-05-20 |
| JPS5083377A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-07-05 |
| NL7415163A (nl) | 1975-05-23 |
| CH617194A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1980-05-14 |
| FR2251324A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-06-13 |
| IE40539B1 (en) | 1979-06-20 |
| DK604574A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |